T. Tencomnao, V. Thongrakard, W. Phuchana, T. Sritharathikhun and S. Suttirat
Published June 22, 2010
Genet. Mol. Res. 9 (2): 1171-1176 (2010)
DOI 10.4238/vol9-2gmr823
About the authors
T. Tencomnao, V. Thongrakard, W. Phuchana, T. Sritharathikhun and S. Suttirat
Corresponding author
T. Tencomnao
E-mail: tewin.t@chula.ac.th
ABSTRACT
Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups withregard to both genotype distributions (c2 = 1.32, d.f. = 2, P = 0.516) and allele frequencies (c2 = 0.01, d.f. = 1, P = 0.913, odds ratio = 0.96, 95% confidence interval = 0.67-1.39). Therefore, this single nucleotide polymorphism appears not to be involved in the etiology of MDD.
Key words: Major depressive disorder; Association study; Rs6311; Serotonin 2A receptor; Single nucleotide polymorphism; Thai population