Yao Xu, Lei An*, Xuhong Lin*
Published September 30, 2024
Genet. Mol. Res. 23 (3): gmr2355
DOI http://dx.doi.org/10.4238/gmr2355

About the Authors
Yao Xu, Lei An*, Xuhong Lin*

Corresponding author:
Lei An
E-mail: hndxal@163.com 

ABSTRACT

Toluene diisocyanate (TDI) is widely used for the synthesis of polyurethane products and caused serious environmental problems. The accumulation of TDI in human body may cause respiratory disease. However, the toxicity of TDI to neural development has been rarely reported. The current study aimed to investigate the toxic effects of TDI exposure on neural development. TDI was injected to the pregnant ICR mice and the proliferation of neurons in vivo was detected. In addition, the toxicity of TDI on cultured PC12 cells was estimated using cell viability assay. The results showed that the exposure to TDI could significantly inhibit proliferation of neurons, suppress cell proliferation, induce cell injury, and promote cell apoptosis. TDI may be a potential toxicant on nervous system.

Key words: Toluene diisocyanate; Neural development; Toxicity, apoptosis.