Z. P. Xu, Q. Song, Z. L. Qiu, L. Li, Z. H. Du, Z. J. Wang
Published: April 20, 2018
Genet. Mol. Res. 17(2): gmr16039906
DOI: https://doi.org/10.4238/gmr16039906

Cite this Article:
Z.P. Xu, Q. Song, Z.L. Qiu, L. Li, Z.H. Du, Z.J. Wang (2018). The effect of acetate Ringer’s solution on inflammatory factors and NF-κB signal pathway in the liver of hemorrhagic shock rats. Genet. Mol. Res. 17(2): gmr16039906. https://doi.org/10.4238/gmr16039906

About the Authors
Z. P. Xu, Q. Song, Z. L. Qiu, L. Li, Z. H. Du, Z. J. Wang

Corresponding Author
Z. J. Wang
Email:ahbyfywzj@163. com

ABSTRACT

Purpose: To investigate the effect of resuscitation with acetated Ringer’s solution during hemorrhagic shock (HS) on inflammatory factors and nuclear factor κB (NF-κB) signaling pathway in liver tissue. Methods: In this study, a rat HS model was established. HS rats received acetated Ringer’s solution, lactated Ringer’s solution and saline for fluid resuscitation. Inflammatory factors (TNF-α, IL-4 and IL-10) for the evaluation of three kinds of resuscitation mfluid anti-inflammatory effect. Expression of proteins in NF-κB pathway was evaluated to elucidate the mechanism of acetated Ringer’s solution in preventing HS-induced liver injury. Results: Although HS upregulated inflammatory response in liver tissue, acetated Ringer’s solution t-treatment can inhibit the inflammation and improve liver injury. We also found that acetated ringer’s solution treatment attenuated HS-induced liver injury in NF-κB pathway. Conclusion: Acetated Ringer’s solution may improve HS-induced liver injury. The mechanism of its action may be by inhibiting the NF-κB pathway.

Key words: Sheeppox virus, Electron microscope, PCR; ORF 103 Gene, GeneBank, Phylogentic analysis.