V.A. Genelhu, E.A. Francischetti, S.F.P. Duarte, B.M.J. Celoria, R.C. Oliveira, P.H. Cabello and M.M.G. Pimentel
Published July 20, 2010
Genet. Mol. Res. 9 (3): 1392-1397 (2010)
DOI 10.4238/vol9-3gmr819

About the Authors
V.A. Genelhu, E.A. Francischetti, S.F.P. Duarte, B.M.J. Celoria, R.C. Oliveira, P.H. Cabello and M.M.G. Pimentel

Corresponding author:
E.A. Francischetti
E-mail: francischetti@globo.com

ABSTRACT

We determined whether ADRβ3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).

Key words: Adrenergic receptor; Obesity; Polymorphism; Adiponectin; Cardiometabolic risk factor.