M.S. Brassesco, E.T. Valera, A.M. Castro-Gamero, D.A. Moreno, T.P. Silveira, B.M. Mori, E.E. Engel, C.A. Scrideli, L.G. Tone
Published: October 06, 2009
Genet. Mol. Res. 8 (4) : 1211-1217
DOI: https://doi.org/10.4238/vol8-4gmr656

Cite this Article:
M.S. Brassesco, E.T. Valera, A.M. Castro-Gamero, D.A. Moreno, T.P. Silveira, B.M. Mori, E.E. Engel, C.A. Scrideli, L.G. Tone (2009). Cytogenetic findings in an epithelioid sarcoma with angiomatoid features.A case report. Genet. Mol. Res. 8(4): 1211-1217. https://doi.org/10.4238/vol8-4gmr656

About the Authors
M.S. Brassesco, E.T. Valera, A.M. Castro-Gamero, D.A. Moreno, T.P. Silveira, B.M. Mori, E.E. Engel, C.A. Scrideli, L.G. Tone

Corresponding author
M.S. Brassesco
E-mail: marsol@rge.fmrp.usp.br/solbrassesco@hotmail.com

ABSTRACT

Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology. We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features. Cytogenetic analysis of epithelioid sarcoma metaphase spreads by GTG-banding revealed a diploid chromosome complement with structural and numerical aberrations. Comparative genomic hybridization analysis demonstrated the amplification of 3p24~pter, 4p15.2-p16 and 18q23, while chromosome losses involved 3p13-p14, 3q24-q26.1, 9q21, and 11q21. Fluorescence in situ hybridization assessment showed normal hybridization patterns for the C-MYC and CCND1 loci; CCND1 RNA overexpression was detected by real-time polymerase chain reaction analysis. Genetic evaluation of this rare condition may be useful in determining if epithelioid sarcoma is associated with a distinct genetic background.

Key words: Angiomatoid features, Cancer, Cytogenetics, Epithelioid sarcoma, Cancer, Cytogenetics.