C.T. Pereira, D.N. Herndon, J.R. Perez-Polo, A.S. Burke, M.G. Jeschke
Published: March 30, 2007
Genet. Mol. Res. 6 (1) : 243-249
Cite this Article:
C.T. Pereira, D.N. Herndon, J.R. Perez-Polo, A.S. Burke, M.G. Jeschke (2007). Scar trek: follicular frontiers in skin replacement therapy. Genet. Mol. Res. 6(1): 243-249.
About the Authors
C.T. Pereira, D.N. Herndon, J.R. Perez-Polo, A.S. Burke, M.G. Jeschke
Corresponding author
M.G. Jeschke
E-mail: majeschk@utmb.edu
This is the first report on in vivo epithelial stem cell (ESC) transfection using intradermal injections of genes encapsulated in liposomes. Skin gene therapy is a relatively new approach with great potential because of the accessibility and ease with which the modified area can be monitored (Alexander and Akhurst, 1995). Liposomes have become attractive as gene therapy vectors due to their non-viral composition, stability, and ability to interact with the cell membrane (Felgner, 1996). We have successfully utilized cationic liposomes as efficient vectors to deliver genes for growth factors such as insulin-like growth factor-I (Jeschke et al., 2000) and keratinocyte growth factor (Jeschke et al., 2002), in a previously described murine model of thermal injury (Jeschke et al., 2001). Read more. . .