Research Article

Related GMR Articles

10/28/2008
C1236T; MDR1; Polymorphism; Turkish population

Human P-glycoprotein (P-gp) is encoded by the MDR1 gene, which is located on chromosomal region 7q21 and consists of 28 exons. To date, over 50 single nucleotide polymorphisms (SNPs) have been reported for the MDR1 gene. The effect of these polymorphisms on P-gp function or their clinical impact is in most cases unknown, but some of the SNPs are known to be of functional ... more

G. Gümüş-Akay; A.R. üstemoğlu; A. Karadağ; A. Sunguroĝlu; A. Sunguroĝlu
01/09/2012
Chinese Hui population; Haplotype; Polymorphism; Rheumatoid arthritis; TIM-1

The T-cell immunoglobulin and mucin domain 1 (TIM-1) is known to be associated with susceptibility to rheumatoid arthritis (RA). We investigated the association of four single-nucleotide polymorphisms (SNPs) in the promoter region of the TIM-1 gene with susceptibility to RA in a Chinese Hui ethnic minority group. Using RFLP or sequence specific primer-PCR, 118 RA patients and 118 non- ... more

J.R. Xu; Y. Yang; X.M. Liu; J.Y. Sun; Y.J. Wang
11/14/2014
Cattle; Haplotype; Polymorphism; Short tandem repeat; Y-chromosome

The aim of this study is to use Y-chromosome gene polymorphism method to investigate regional differences in genetic variation and population evolution history of the Chinese native cattle breeds. Six Y-chromosome short tandem repeat (Y-STR) loci (UMN0929, UMN0108, UMN0920, INRA124, UMN2404, and UMN0103) were analyzed using 1016 healthy ... more

Y.P. Xin; L.S. Zan; Y.F. Liu; W.Q. Tian; H.B. Wang; G. Cheng; A.N. Li; W.C. Yang
10/27/2014
Haplotype; Kazakh; Linkage disequilibrium; Metabolic syndrome; Polymorphism; PPARγ

We investigated the relationship between haplotype and linkage disequilibrium of the PPARγ gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 and metabolic syndrome (MS) in the Kazakh people of Xinjiang Province. For PPARγ, rs3856806, rs12490265, rs1797912, and rs1175543 genotypes were detected in 489 subjects (including 245 MS patients and 244 controls) using matrix- ... more

S.X. Guo; H. Guo; R.L. Ma; Y.S. Ding; J.Y. Zhang; J.M. Liu; M. Zhang; Q. Niu; N. Qiang; S.G. Li; C.N. Qi
04/07/2009
aldosterone; cortisol; Genetic polymorphism; MDR1; menstrual cycle; P-glycoprotein

ABCB1, also known as MDR1/P-glycoprotein, can transport cortisol and aldosterone. We examined the effects of ABCB1 polymorphisms on serum levels of cortisol and aldosterone among different phases of the normal menstrual cycle in 51 non-pregnant healthy Japanese female volunteers (22 ± 1 years old). The menstrual cycle was divided into three phases: premenstrual phase (14 days preceding the ... more

T. Nakamura; N. Okamura; M. Yagi; H. Omatsu; M. Yamamori; A. Kuwahara; K. Nishiguchi; M. Horinouchi; K. Okumura; T. Sakaeda
11/22/2013
Benzene; Bone marrow mononuclear cells; MDR1; P-glycoprotein

ATP-binding cassette super family (ABC) proteins are considered key to oncology and pharmacology studies. We examined the effect of benzene on ABC pump protein levels in C57BL/6 mouse bone marrow mononuclear cells. After a 2-week gavage (200 mg/kg, 5 days per week), the number of peripheral leukocytes, lymphocytes and basophils dropped significantly; there was also a significant decrease ... more

J.S. Huang; M.D. Zhao; J.M. Shi; J.H. Zhang; B. Li; W. Fan; Y.L. Zhou
07/04/2014
Breast cancer; Fibrocystic changes; Malignant breast lesions; MDR1; P-glycoprotein

We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro Médico de Occidente (México) were included in the analysis. Genotyping was performed by polymerase ... more

N.M. Macías-Gómez; M. Gutierrez-Angulo; E. Leal-Ugarte; L. Ramírez-Reyes; J. Peregrina-Sandoval; J.P. Meza-Espinoza; R. Solano; dela Luz Ayala-Madrigal; S. Telles
02/13/2015
ABCB1; Breast cancer; MDR1; Polymorphisms; Pre- and postmenopausal women

MDR1, which is encoded by the ABCB1 gene, is involved in multidrug resistance (hydrophobic), as well as the elimination of xenotoxic agents. The association between ABCB1 gene polymorphisms and breast cancer risk in different populations has been described previously; however, the results have been inconclusive. In this study, we examined the association between ... more

S.A. Gutiérrez-Rubio; A. Quintero-Ramos; A. Durán-Cárdenas; R.A. Franco-Topete; J.M. Castro-Cervantes; A. Oceguera-Villanueva; L.M. Jiménez-Pérez; L.M.A. Balderas-Peña; G. Morgan-Villela; A. Del-Toro-Arreola; A. Daneri-Navarro
12/14/2011
Colorectal cancer risk; Genotype; Haplotype; MTHFR

Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer. We made a case-control study to analyze a possible association of MTHFR gene polymorphisms C677T and A1298C ... more

H. Li; W.L. Xu; H.L. Shen; Q.Y. Chen; L.L. Hui; L.L. Long; X.L. Zhu
12/10/2013
China (CHB); Chinese Han in Beijing; Haplotype; Linkage disequilibrium; Tibetan; UGT1A

As part of a series of pharmacogenomics studies of the Chinese population, we investigated genetic polymorphisms of some UGT1A regions. The three genes that were analyzed were UGT1A9, 1A7, and 1A1; we sequenced their exons, together with promoters, surrounding introns and 3'-untranslated regions (3ꞌUTR) in 100 unrelated-healthy Chinese Tibetan individuals. We compared the data with ... more

W. Yan; Y.W. Wang; F.F. Yang; M. Wang; X.Q. Zhang; J. Dong; E. Chen; J. Yang

Pages