Research Article

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11/30/2019
Genetic polymorphism; HIV; Interleukin-7 receptor; Limpopo Province; Opportunistic Infections; Single nucleotide polymorphism

Genetic polymorphism of cytokine genes has been shown to be associated with susceptibility to diseases. We investigated the frequency of the IL-7 receptor-α +510 CT SNP in relation to pain and other symptoms among HIV and AIDS patients attended at various South African hospitals for treatment. Demographic as well as clinical data was obtained through structured ... more

T.C. Nangammbi; G.T. Moloro; A. Samie
10/05/2016
Blood pressure; IL-6; Lipid; Obese children; STEAP4; TNF-α

The aim of this study was to investigate the expression and clinical significance of the obesity-associated gene STEAP4 in obese children. Fifty-three obese children and 33 children with a standard body weight (control) from our hospital were recruited to this study. The expression of STEAP4 mRNA and protein in the adipose tissue were detected by reverse transcriptase polymerase ... more

H.M. Xu; Y.Z. Cui; W.G. Wang; H.X. Cheng; Y.J. Sun; H.Y. Zhao; Y.Q. Yan; H.M. Xu; Y.Z. Cui; W.G. Wang; H.X. Cheng; Y.J. Sun; H.Y. Zhao; Y.Q. Yan
08/28/2015
Gene duplication; Genetic polymorphism; Yak; κ-casein

The objective of this study was to compare 12 bp-duplication polymorphisms in exon 4 of the κ-casein gene among 3 breeds/populations of yak (Bos grunniens). Genomic DNA was extracted from yak blood or muscle samples (N = 211) and a partial sequence of exon 4 of κ-casein gene was amplified by polymerase chain reaction. A polyacrylamide gel electrophoresis assay of the products (169 bp ... more

S. Pingcuo; J. Gao; Z.R. Jiang; S.Y. Jin; C.Y. Fu; X. Liu; L. Huang; Y.C. Zheng
08/03/2015
-2578C/A; Breast cancer; Genetic polymorphism; Meta-analysis; VEGF; 405G/C

This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis. A systematic computerized search of PubMed, Google Scholar, and Web of Science databases was performed to identify relevant publications. After rigorous searching and screening, 9 eligible case- ... more

Y. Zhang; Y.F. Yu; J.Z. Wang; H. Jia
07/03/2015
Benign prostate hyperplasia; Genetic polymorphism; Prostate cancer

We compared single-nucleotide polymorphisms for point mutations in cytochrome P450 genes, including cytochrome P450c17α (CYP17), cytochrome P450 aromatase (CYP19), steroid-5-a-reductase (SRD5A2), and prostate-specific antigen (PSA) involved in androgen and estrogen production. Between January 2008 and January 2010, 90 patients were enrolled in the study. Of ... more

E. Ersekerci; M. Sofikerim; S. Taheri; A. Demirtas; F. Halis
12/02/2015
Genetic polymorphism; Matrix metalloproteinase-3; mRNA expression; Rheumatoid arthritis

Matrix metalloproteinase-3 (MMP-3) can mediate the occurrence and development of rheumatoid arthritis (RA). The MMP3 promoter gene exhibits polymorphism with 5A/6A alleles. We investigated the correlation between the expression of MMP3 gene polymorphism and RA to provide an objective basis for prognosis evaluation. We enrolled 80 RA patients and 80 healthy subjects. Enzyme- ... more

M.J. Ma; H.C. Liu; X.Q. Qu; J.L. Wang
11/13/2015
ACE; Digestive system cancer; Genetic polymorphism; I/D polymorphism

The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of ... more

J. Wang; S. Yang; F.H. Guo; X. Mao; H. Zhou; Y.Q. Dong; Z.M. Wang; F. Luo
10/30/2015
Colorectal cancer; Genetic polymorphism; HIV-1 infection; Leprosy; NLRP3; Rheumatoid arthritis

Using a meta-analysis framework, we investigated the association between the NLRP3 rs35829419 polymorphism and increased susceptibility to diverse diseases in humans. Relevant published studies were identified through a comprehensive and systematic electronic search, using the following scientific literature databases: Science Citation Index, the Cochrane Library, PubMed, Embase ... more

Q. Zhang; H.W. Fan; J.Z. Zhang; Y.M. Wang; H.J. Xing
02/05/2016
Genetic polymorphism; Interleukin-1 gene; Meta-analysis; Periodontitis

Genetic variations in human interleukin-1 (IL-1) genes are known to be involved in inflammatory disorders. The rs17561 and rs1143634 polymorphisms of IL-1α and IL-1β, respectively, have been increasingly recognized as important regulators in the development of periodontitis. However, the existence of a specific association remains controversial. Therefore, we ... more

W.T. Yin; Y.P. Pan; L. Lin; W.T. Yin; Y.P. Pan; L. Lin
01/28/2018
Bulgarian Rhodopean cattle; Genetic polymorphism; Milk proteins; αS1 - casein

Milk protein genetic polymorphisms of the genus Bos provoke a significant scientific interest, mainly associated with their evolution, population structure, breeding and hybridization. The aim of present study is to investigate the influence of the genetic variants of αS1- casein gene with respect to milk production and quality of native for Bulgaria cattle breed ... more

P. Hristov; D. Teofanova; A. Georgieva; G. Radoslavov

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