Research Article

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03/31/2015
Asthma; Meta-analysis; Polymorphism; Single nucleotide polymorphism

The IL-4R Q576R polymorphism has been reported to increase susceptibility to asthma, but the results are controversial. Thus, we performed a meta-analysis to evaluate the association of the IL-4R Q576R polymorphism and asthma risk in the Chinese Han population. A total of sixteen eligible case-control studies that evaluated the relationship between the IL-4R ... more

Z.Y. Huang; B.J. Cheng; G.J. Cai; B.F. Zhang
03/27/2015
Autism; Differentially expressed genes; Expression data; Meta-analysis; Microarray

The purpose of this study was to identify differentially expressed (DE) genes and biological processes associated with changes in gene expression in autism. We performed a meta-analysis using new publicly available Gene Expression Omnibus (GEO) datasets of autism. We performed Gene Ontology (GO) enrichment analyses and pathway analysis using the Kyoto Encyclopedia of Genes and Genomes ( ... more

L.F. Ning; Y.Q. Yu; E.T. GuoJi; C.G. Kou; Y.H. Wu; J.P. Shi; L.Z. Ai; Q. Yu
03/13/2015
C-erbB-2; Gastric cancer; Meta-analysis; Prognosis

The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data ... more

Z.Q. Wang; B.J. Sun
02/13/2015
Estrogen receptor alpha; Fracture; Gene polymorphism; Meta-analysis

Numerous studies have evaluated the association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and fracture risk in postmenopausal women. However, the results have been inconsistent. We performed a meta-analysis to examine the association between the ESR1 gene PvuII polymorphism and fracture risk in postmenopausal women. Studies ... more

W. Deng; J.C. Han; L. Chen; W.L. Qi
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FABP2; Meta-analysis; Metabolic syndrome; Obesity; Type 2 diabetes mellitus

Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and ... more

Y. Liu; G. Wu; L. Han; K. Zhao; Y. Qu; A. Xu; Q. Huang
03/06/2015
Meta-analysis; Myocardial infarction; Polymorphism; TNF-β

Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the ... more

D.W. Suo; Q. Hu; J. Chen; Q.H. Sun; H. Guo
02/13/2015
GSTM1; Lung cancer; Meta-analysis; Polymorphism

The relationship between glutathione S-transferase M1 (GSTM1) genetic polymorphisms and lung cancer has been reported previously. However, the results are not consistent. Therefore, to clarify the association between GSTM1 polymorphisms and lung cancer, we performed a meta-analysis based on published studies. We used the Revman 5.0 software to perform literature ... more

H. Liu; H.F. Ma; Y.K. Chen
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CYP1A1; Gene polymorphism; Hepatocellular carcinoma; Meta-analysis

Numerous studies have evaluated the association between CYP1A1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. However, the specific association is still controversial. The aim of our study was to clarify the effects of CYP1A1 gene polymorphisms (3801 T>C and A2455G) on HCC risk by conducting a meta-analysis. We conducted searches of the literature published in PubMed and ... more

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02/06/2015
Alzheimer’s disease; Angiotensin-converting enzyme gene; Low-density lipoprotein receptor-related protein gene; Meta-analysis; Polymorphism; Presenilin 1 gene

The objective of this study was to assess the associations of presenilin 1 (PS1) 1/2, angiotensin I-converting enzyme (ACE) insertion/deletion (I/D), and low-density lipoprotein receptor-related protein (LRP) C/T polymorphisms with the risk of Alzheimer’s disease (AD) in the Chinese population. PS1 1/2, ACE I/D, and LRP C/T, which are commonly investigated polymorphisms, were evaluated to ... more

L. Yang; H.H. Zhou; Y.F. Ye; X.W. Fan; Y.J. Wang; Y. Meng
02/06/2015
ADAM33; Asthma; Meta-analysis; Polymorphism

In this study, we evaluated the associations between the V4 (rs2787094 G>C) polymorphism in a disintegrin and metalloproteinase domain 33 (ADAM33) gene and asthma risk. We searched Web of Science, PubMed, Google Scholar, EBSCO, Cochrane Library, and CBM databases from inception through August 2013, without language restrictions. Meta-analysis was performed using the STATA 12.0 ... more

W. Zheng; L. Wang; X. Su; X.F. Hu

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