Research Article

Related GMR Articles

09/28/2017

Screening of peste des petits ruminants virus in a population of district Khairpur, Pakistan.

Animals; Goats; Pakistan; Peste-des-Petits-Ruminants; Peste-des-petits-ruminants virus; Serologic Tests

Goats are the Pakistan's fastest growing ruminants, and Pakistan is the third largest goat producer in the world after India and China. Goat meat preference is the main reason for its increased demand. In the country, there are 25 goat breeds and two wild relatives such as Mark and Goats. At present, Pakistan has 53.8 million goats, according to the 2006 GOP report, and their population growth ... more

A.K. Maitlo; J.A. Ujan; S.A. Ujjan; M. Ruk; B.A. Memon; A.A. Mahar; A.A. Ujjan
1/23/2017

Analysis of specific serum markers of colon carcinoma using a Bhattacharyya-based support vector machine.

Biomarkers, Tumor; Colonic Neoplasms; Humans; Models, Theoretical; Reproducibility of Results; Support vector machine

We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of the model was checked. High accuracy was assumed to indicate the ... more

W.Y. Yang; G. Shi; L.P. Wu; S.T. Wei; Y.N. Huang; L.X. Tan; R.Z. Yang; C.X. Yan; E.T. Guo; H.Y. Wang; J.Z. Tong; Y. Dong; D.Z. Han
3/22/2017

Is differential expression of p16INK4a based on the classification of uterine smooth muscle tumors associated with a different prognosis? A meta-analysis.

Biomarkers, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Female; Genes, p16; Genetic predisposition to disease; Humans; Leiomyoma; Leiomyosarcoma; Neoplasm Recurrence, Local; Prognosis; Smooth Muscle Tumor; Uterine Neoplasms

We conducted a meta-analysis to examine p16INK4a expression in uterine smooth muscle tumors (USMTs). Although the prognostic value of tumor suppressor p16INK4a has been elucidated in a variety of cancers and precancerous lesions, its role in USMTs is not well established. We searched PubMed, Web of Science, and Embase for publication son p16INK4a expression in USMTs. Strict inclusion and ... more

H.Y. Cao; S. Yang; S. Wang; L.Y. Deng; J.Y. Lou
4/20/2017

BCR-ABL1 transcript types showed distinct laboratory characteristics in patients with chronic myeloid leukemia.

Antineoplastic Agents; Biomarkers, Tumor; Female; Fusion Proteins, bcr-abl; Humans; Imatinib mesylate; Leukemia, Myeloid, Chronic-Phase; Leukocyte Count; male; Middle Aged; Platelet count; RNA, Messenger

In chronic myeloid leukemia (CML) two main types of messenger RNA (e14a2 and e13a2) can be produced by BCR-ABL1 gene rearrangement. Due to conflicting results, the clinical value of these transcripts remains controversial. The aim of this study was to identify associations of e14a2 and e13a2 transcripts with laboratory variables and also the response to treatment. This study included 203 adult ... more

A.P. Vasconcelos; I.F. Azevedo; F.C.B.C. Melo; W.B. Neves; A.C.A.C. Azevedo; R.A.M. Melo
4/28/2017

Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.

Biomarkers, Tumor; Carcinoma, Signet Ring Cell; CDX2 Transcription Factor; Codon; Female; Genes, ras; Humans; male; Middle Aged; Mucins; Mutation; Mutation Rate; Neoplasm Metastasis; Phenotype; Stomach neoplasms

We aimed to analyze gastric signet ring cell (SRC) carcinoma subtypes by investigating gastric and intestinal phenotypic marker expression, and explore the relationship between phenotype and K-ras mutation. Immunohistochemistry was performed on 163 SRC carcinoma patient specimens to detect gastric (MUC1, MUC5AC, and MUC6) and intestinal (MUC2 and CDX2) phenotypic markers, and tumors were ... more

Z.F. Xiong; J. Shi; Z.H. Fu; H.P. Wan; L.X. Tu
05/10/2017

CADM1 mRNA expression and clinicopathological significance in esophageal squamous cell carcinoma tissue.

Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; male; Middle Aged; Neoplasm Metastasis; RNA, Messenger; Up-Regulation

The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and streptavidin-peroxidase (SP) immunohistochemistry; adjacent tissues ... more

J.B. Qian; H.B. Liu; Y. Zhu; F. Lu; Q.C. Yang; Y. Shen
09/27/2017

Evolution of the genus Mimivirus based on translation protein homology and its implication in the tree of life.

Evolution, Molecular; Mimiviridae; Models, Genetic; Phylogeny; Protein Biosynthesis; Sequence Homology; Viral Proteins

The natural history of mimiviruses (i.e., viruses that are members of the Mimivirus genus) is a challenge for modern biology. A new domain of life to include these organisms has been proposed from analysis of gene conservation. We analyzed the evolutionary relationship of proteins involved in the translation system, and our data show that mimiviruses are a sister group of Eukarya. New data ... more

V.M. Marcelino; M.V.P.C. Espinola; V. Serrano-Solis; S.T. Farias

Pages