Research Article

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Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Adhesion Molecules; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; male; Microfilament Proteins; Neoplasm Recurrence, Local

Lung cancer is the leading cause of cancer death in men and the second leading cause of cancer death in women worldwide. Fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers. The expression and the serum levels of fascin-1 and laminin-5 in patients with non-small cell lung cancer (NSCLC) were analyzed in this study. The expression of fascin-1 and ... more

L. Yang; Y. Teng; T.P. Han; F.G. Li; W.T. Yue; Z.T. Wang
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Case-control studies; Chronic obstructive pulmonary disease; Genetic predisposition to disease; Matrix metalloproteinases; Single nucleotide polymorphism

There are many candidate genes for chronic obstructive pulmonary disease (COPD). One such candidate is the group of genes that code for matrix metalloproteinases (MMPs), which play an essential role in tissue remodeling and repair associated with COPD. We tested the hypothesis that polymorphic variation in MMP genes influences the risk of developing COPD by examining functional ... more

H. Schirmer; B. da Silva; P.J.Z. Teixeira; J.S. Moreira; A.L.S. Moreira; D. Simon
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Case-control studies; Dopamine; Frequency; Genetic polymorphism; Nursing; Receptors; Schizophrenia

Schizophrenia is considered one of the most severe and complex mental disorders; it affects both the quality of life of the patient and his family. The dopamine hypothesis is the main concept concerning antipsychotic activity. Patients with treatment-refractory schizophrenia have a lower capacity for dopamine synthesis than those with a good response to first- ... more

F.D.D. Nunes; J.A.F. Pinto; P.H.B. Freitas; L.L. Santos; R.M. Machado
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Apoptosis; Curcumin; Invasion; Melanoma; Migration; Proliferation

Malignant melanoma is a melanocytic tumor with a high potential of invasion and metastasis. Curcumin is extracted from Curcuma longa L.; curcumin has anti-tumor efficacy in multiple systemic malignancies. Here, we investigated the effect of curcumin on A375 human melanoma cells. A375 cells were cultivated, passaged, and treated with different concentrations of curcumin. We ... more

Y.P. Zhang; Y.Q. Li; Y.T. Lv; J.M. Wang
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Immune; Inflammation; Melanoma; Microbial Dysbiosis; Probiotics
 Antibiotic-induced disruption of the intestinal microbiota
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X. Ren; X. Zhang; Y. Zhu; Y. Gamallat; A. Meyiah; S. Ma; Y. Xin
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Autoantibody; Autoantigen; Heat shock protein 70; Hepatitis B virus; Melanocytes; Vitiligo

We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melanocyte were identified by immunofluorescence. Autoantibodies against ... more

M.C. Zhu; C.G. Liu; D.X. Wang; Z. Zhan
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Apoptosis; Aquaporin; Cell proliferation; Diabetes; Myocardial cell

The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric analysis of Annexin V-fluorescein ... more

P.F. Zhao; M.J. Sun
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Apoptosis; Cell proliferation; Checkpoint kinase 1; Gamma-aminobutyric acid type A receptor; p53; Propofol

We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferation and viability of rENSCs was ... more

J.W. Wang; W.W. Cheng; T. Xu; Z.Y. Yang
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Cell cycle; Cell proliferation; Gastric cancer; Kallikrein 12; Small interfering RNA

Abnormal expression of the kallikrein (KLK) family of serine proteases closely correlates with onset, progression, and prognosis of endocrine gland-related malignant tumors. The aim of this study was to evaluate how downregulation of KLK12 influenced cell cycle and proliferation of the AGS gastric cancer cell line. KLK12 was detected by western blot in GES-1 normal gastric ... more

X.S. Li; X.L. He; X.S. Li; X.L. He
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Adipose-derived stem cell; Cell apoptosis; Cell proliferation; Histone acetylation; Stem cell multipotency

Adipose-derived stem cells (ADSCs) show nearly unlimited potential in medical and animal science. Currently, understanding of the biological mechanisms regulating ADSC growth in vitro remains very limited. Histone acetylation, an epigenetic modification, plays a key role in maintaining stem cell properties. To further study its effect on ADSC growth ... more

X. Wang; F.X. Zhang; Z.M. Wang; Q. Wang; H.F. Wang; Y. Ren; D.P. Tai; H. Liang; D.J. Liu; X. Wang; F.X. Zhang; Z.M. Wang; Q. Wang; H.F. Wang; Y. Ren; D.P. Tai; H. Liang; D.J. Liu

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