Research Article

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2/23/2017

Effects of miRNA-143 and the non-coding RNA MALAT1 on the pathogenesis and metastasis of HeLa cells.

Blotting, Western; Cadherins; Cell Movement; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Hela cells; Humans; MicroRNAs; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; Uterine cervical neoplasms; Vimentin

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate ... more

L. Zhang; H.E.X.D. Niyazi; H.R. Zhao; X.P. Cao; M.N.S. Abudula; W.J. Ye; S.A. Zhang; R.H.M. Yiming; Y. Zhang; W.P. Su; R. Chen; Y. Ouyang; N. Miao; Y.X. Bao
05/25/2017

Effect of 1,25(OHD on the proliferation of human mesangial cells and their expression of Ki67.

Cell line; Cell proliferation; Epidermal growth factor; Humans; Ki-67 Antigen; Mesangial cells; Vitamin D; Vitamins

Previous studies have found that 1,25-dihydroxyvitamin D [1,25(OH)D or VD] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)D on the proliferation of cultured human mesangial cells and their expression of Ki67 in vitro, and ... more

D. Zhao; C.J. Zhang; R. Yang; J.P. Chen; L. Ma; G. Liu; X.P. Yang
05/31/2017

Influence of processing and storage of integral grape juice (Vitis labrusca L.) on its physical and chemical characteristics, cytotoxicity, and mutagenicity in vitro.

Animals; Carbohydrates; Cell Line, Tumor; Cell proliferation; DNA damage; Food Handling; Food Quality; Food storage; Fruit and Vegetable Juices; Rats; Ultraviolet Rays; Vitamins; Vitis

Integral grape juice is extracted from the grape through processes that allow the retention of their natural composition. However, due to the severity of some processes, fruit juices can undergo changes in their quality. The present study evaluated the cytotoxic and mutagenic effects of integral grape juice by a cytokinesis-blocked micronucleus assay in Rattus norvegicus hepatoma cells (HTC) ... more

E. Düsman; I.V. Almeida; E.P. Pinto; L. Lucchetta; V.E.P. Vicentini
3/22/2017

Prevention of DNA damage and anticarcinogenic activity of Activia in a preclinical model.

1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Colorectal neoplasms; Dietary Supplements; DNA damage; Intestinal Mucosa; male; Mice; Probiotics; Yogurt

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a ... more

S.M.A. Limeiras; F.M. Ogo; L.A.L. Genez; C.M. Carreira; E.J.T. Oliveira; L.R. Pessatto; S.C. Neves; J.R. Pesarini; L.C. Schweich; R.A. Silva; W.B. Cantero; A.C.M.B. Antoniolli-Silva; R.J. Oliveira
3/16/2017

Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine.

1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Colorectal neoplasms; DNA damage; Ethanol; male; Mice; Micronucleus tests; Plant Extracts; Xenograft Model Antitumor Assays

The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has ... more

S.M.A. Limeiras; B.C. Oliveira; L.R. Pessatto; J.R. Pesarini; C.A.L. Kassuya; A.C.D. Monreal; W.B. Cantero; R. Antoniolli-Silva; A.C.M.B. Antoniolli-Silva; M.E.A. Stefanello; R.J. Oliveira
12/21/2015

Aquaporin in the proliferation and apoptosis of diabetic myocardial cells

Apoptosis; Aquaporin; Cell proliferation; Diabetes; Myocardial cell

The aim of this study was to explore the effect of aquaporin on the molecular mechanism of human diabetic myocardial cell apoptosis. The methylthiazolyle tetrazolium assay was used to detect the inhibitory effect of different concentrations of aquaporin on cell growth. The rate of aquaporin-induced myocardial cell apoptosis was detected by flow cytometric analysis of Annexin V-fluorescein ... more

P.F. Zhao; M.J. Sun
11/23/2015

Propofol induces apoptosis and inhibits the proliferation of rat embryonic neural stem cells via gamma-aminobutyric acid type A receptor

Apoptosis; Cell proliferation; Checkpoint kinase 1; Gamma-aminobutyric acid type A receptor; p53; Propofol

We investigated the effect of propofol on the proliferation and viability of rat embryonic neural stem cells (rENSCs) and the potential mechanisms involved. rENSCs were isolated and cultured in vitro and treated with 1, 10, or 50 μM propofol, while the control group was treated with 0.1 μM dimethyl sulfoxide. The effect of propofol on the proliferation and viability of rENSCs was ... more

J.W. Wang; W.W. Cheng; T. Xu; Z.Y. Yang
12/19/2016

Targeting of miR-432 to myozenin1 to regulate myoblast proliferation and differentiation.

3' Untranslated Regions; Animals; Cell differentiation; Cell proliferation; Cells, Cultured; Down-regulation; Gene Expression Regulation, Developmental; Microfilament Proteins; MicroRNAs; Muscle development; Muscle Proteins; Myoblasts; Swine

MicroRNAs (miRNAs) play important roles in the development and biochemical functions of skeletal muscles. However, targeting of miRNAs to structural genes involved in Z-discs have not been investigated. Here, we describe a highly expressed miRNA, miR-432, in pig embryonic skeletal muscle, which appeared to target myozenin1 (MYOZ1), a protein involved in the muscular sarcomere microstructure. ... more

R.M. Ren; H. Liu; S.H. Zhao; J.H. Cao
12/19/2016

Different responses of vanillic acid, a phenolic compound, in HTC cells: cytotoxicity, antiproliferative activity, and protection from DNA-induced damage.

Animals; Antimutagenic Agents; Cell line; Cell proliferation; DNA damage; Dose-Response Relationship, Drug; Plant Extracts; Rats; Vanillic Acid

The consumption of healthy and natural foods has increased over the last few years, primarily because these foods are rich in substances with biological properties of interest, such as exerting anticancer effects and decreasing oxidative stress in living tissues. These foods support adequate nutrition, maintain health, and improve quality of life. Vanillic acid (VA) is a phenolic compound used ... more

I.V. Almeida; F.M.L. Cavalcante; V.E.P. Vicentini
1/23/2017

Effect of pregnancy on the proliferation of rat adipose-derived stem cells.

Adipose tissue; Animals; Cell differentiation; Cell proliferation; Estradiol; Female; Pregnancy; Progesterone; Rats; Stem cells

Stem cell therapy faces many problems including poor survival rates and low viability. Enhancing the biological functions of stem cells improves efficacy of therapies. Estrogen, whose levels are elevated during pregnancy, affects the properties of bone marrow mesenchymal stem cells. Evidence suggests that adipose-derived stem cells (ADSCs), which are a type of adult mesenchymal stem cells, can ... more

J.N. Li; Y. Zhang; Y.F. Wang; J.Y. Chen

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