Research Article

Related GMR Articles

1/23/2017
Apoptosis; Cell Line, Tumor; Cell proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; RNA interference; Uterine cervical neoplasms

Cervical carcinoma is a life-threatening illness posing considerable danger to women's health. microRNAs (miRNAs) have been shown to regulate multiple cellular events, including growth and proliferation, and miR-187 is thought to regulate the growth and apoptosis of certain cell types. Our study focused on the influence of miR-187 on the growth, proliferation, and apoptosis of SiHa cervical ... more

C.Y. He; J. Yang
1/23/2017
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Cell survival; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms; RNA, Long Noncoding

The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP70 cells. Expression levels of these lncRNAs were then verified in ... more

H. Yan; J.Y. Xia; F.Z. Feng
2/23/2017
Blotting, Western; Cadherins; Cell Movement; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Hela cells; Humans; MicroRNAs; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; Uterine cervical neoplasms; Vimentin

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate ... more

L. Zhang; H.E.X.D. Niyazi; H.R. Zhao; X.P. Cao; M.N.S. Abudula; W.J. Ye; S.A. Zhang; R.H.M. Yiming; Y. Zhang; W.P. Su; R. Chen; Y. Ouyang; N. Miao; Y.X. Bao
2/23/2017
Apoptosis; Blotting, Western; Breast neoplasms; Cell Line, Tumor; Cell Movement; Cell proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Down-regulation; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; MCF-7 cells; MicroRNAs; Microscopy, Electron; Neoplasm Invasiveness; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Transcription factors

Breast cancer, which derives from the epithelium of the mammary glands, is one of the most common cancers diagnosed in women globally. To date, the authors of many studies have reported that the deregulation of microRNAs (miRNAs) plays a crucial role in the occurrence, development, and metastasis of tumors. Here, we discovered that miR-660-5p was upregulated in the breast cancer cell lines ... more

Y. Shen; Y.F. Ye; L.W. Ruan; L. Bao; M.W. Wu; Y. Zhou
3/08/2017
Adaptor Proteins, Signal Transducing; Adult; Aged; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell proliferation; Down-regulation; Female; Genes, Tumor Suppressor; Humans; KB Cells; male; MicroRNAs; Middle Aged; Monomeric GTP-Binding Proteins; Mouth Neoplasms; RNA, Messenger

Ras association domain family member 5 (RASSF5), a member of the Ras association domain family, induces cell apoptosis by phosphorylating FOXO3a, which triggers target gene BIM (pro-apoptotic factor) activation. MiR-214 is overexpressed in oral cancer tissue, indicating its possible involvement in oral cancer pathogenesis. Bioinformatics analysis has revealed a complimentary sequence between ... more

T.K. Li; K. Yin; Z. Chen; Y. Bao; S.X. Zhang
3/16/2017
Actins; Apoptosis; Cell proliferation; Cells, Cultured; Coculture Techniques; Down-regulation; Hepatic stellate cells; Hepatocyte growth factor; Humans; Mesenchymal stem cells; Paracrine Communication

We investigated the paracrine effects of bone marrow mesenchymal stem cells (BMSCs) on the proliferation, apoptosis, and alpha-actin-2 (ACTA2) expression of hepatic stellate cells (HSCs), and explored the possible mechanisms of hepatocyte growth factor (HGF). We established a co-culture system by culturing BMSCs on the upper layer and HSCs on the lower layer of a 6-well Transwell plate. Normal ... more

H.J. Cao; M.D. Wang; S.G. Li; L. Zhu; J.H. Zheng
3/30/2017
3' Untranslated Regions; AC133 Antigen; Apoptosis; Cell cycle; Cell Line, Tumor; Cell Movement; Cell proliferation; Gene Expression Regulation, Neoplastic; Glioma; Humans; MicroRNAs; Nervous System Neoplasms; RNA, Messenger; Transfection

MiR-200b, a member of the microRNA-200 family, has been identified to be capable of suppressing glioma cell growth through targeting CREB1 or CD133. However, whether miR-200b affects the biological behavior (proliferation, invasion, and migration) of glioma cells is poorly understood. The aim of this study was to evaluate the effect of miR-200b on the biological behavior of glioma cells in ... more

C. Zhao; Z.G. Ma; S.L. Mou; Y.X. Yang; Y.H. Zhang; W.C. Yao
4/13/2017
Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Breast neoplasms; Carotenoids; Cell proliferation; Humans; Lycopene; MCF-7 cells; Tumor Suppressor Protein p53

Breast cancer adversely affects the health status of women; therefore, the prevention and treatment of breast cancer is of critical importance. Lycopene is known to possess several biological effects such as removal of free radicals, alleviation of biological oxidative injury, and inhibition of tumor growth. In this study, we aimed to illustrate the effect of lycopene on tumor cell ... more

S.J. Peng; J. Li; Y. Zhou; M. Tuo; X.X. Qin; Q. Yu; H. Cheng; Y.M. Li
05/31/2017
Animals; Carbohydrates; Cell Line, Tumor; Cell proliferation; DNA damage; Food Handling; Food Quality; Food storage; Fruit and Vegetable Juices; Rats; Ultraviolet Rays; Vitamins; Vitis

Integral grape juice is extracted from the grape through processes that allow the retention of their natural composition. However, due to the severity of some processes, fruit juices can undergo changes in their quality. The present study evaluated the cytotoxic and mutagenic effects of integral grape juice by a cytokinesis-blocked micronucleus assay in Rattus norvegicus hepatoma cells (HTC) ... more

E. Düsman; I.V. Almeida; E.P. Pinto; L. Lucchetta; V.E.P. Vicentini
06/29/2017
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Colorectal neoplasms; Curcumin; Drug Resistance, Neoplasm; Heat-shock proteins; HSP27 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Molecular chaperones; Proto-Oncogene Proteins c-bcl-2; Survivin

Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and the reversal effects of 5-FU in combination with curcumin on HCT-8/5 ... more

Y.X. Fan; P. Abulimiti; H.L. Zhang; Y.K. Zhou; L. Zhu

Pages