Research Article

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09/27/2017
Acyclic Monoterpenes; DNA damage; Hep G2 Cells; Humans; Monocytes; Terpenes

Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations, this study was designed to ... more

T.B. Queiroz; G.F. Santos; S.C. Ventura; C.A. Hiruma-Lima; I.O.M. Gaivão; E.L. Maistro
09/27/2017
Ecuador; Gene frequency; Humans; Microsatellite Repeats; Polymorphism, Genetic; Population

One hundred and eighty-two samples of unrelated people who requested the paternity test at the Molecular Biology and Genetics Laboratory of the Catholic University of Cuenca-Ecuador in the province of Azuay were studied, except for the D1S1656 (180 samples) and SE33 (89 samples) markers. The STRs D22S1045, D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01, FGA, D1S1656, ... more

P.P. Orellana; C.F. Andrade; C.L. Arciniegas; G.C. Iannacone
12/02/2016
Animals; Body weight; Cattle; Genome-wide association study; Genotype; Models, Biological; Phenotype; Polymorphism, Single Nucleotide; Quantitative trait loci

This study aimed to investigate the predictability of a phenotype when using a dynamic model of cattle growth. Genotypic and phenotypic information on Nellore (Bos indicus) cattle were used in a genome-wide association analysis designed to contrast the biological interpretation of core parameters [conversion efficiency of metabolizable energy to net energy for gain (k) and adjusted final ... more

M.C. Freua; M.H.A. Santana; R.V. Ventura; J.B.S. Ferraz
12/02/2016
Animals; Brazil; Breeding; Cattle; Gene frequency; Genetic markers; Leptin; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Red Meat; Sequence Analysis, DNA

Brazil is the world's largest producer of beef cattle; however, the quality of its herds needs to be improved. The use of molecular markers as auxiliary tools in selecting animals for reproduction with high pattern for beef production would significantly improve the quality of the final beef product in Brazil. The leptin gene has been demonstrated to be an excellent candidate gene for bovine ... more

R.C. Guimarães; J.S.N. Azevedo; S.C. Corrêa; J.E.G. Campelo; E.M. Barbosa; E.C. Gonçalves; S. Filho
12/02/2016
cluster analysis; Genes, Plant; Manihot; Phylogeny; Polymorphism, Single Nucleotide; Sequence alignment; Sequence Analysis, DNA; Starch

The distribution and frequency of single nucleotide polymorphisms (SNPs) can help to understand changes associated with characteristics of interest. We aimed to evaluate nucleotide diversity in six genes involved in starch biosynthesis in cassava using a panel of 96 unrelated accessions. The genes were sequenced, aligned, and used to obtain values for nucleotide diversity (π), segregating ... more

L.M. Vasconcelos; A.C. Brito; C.D. Carmo; E.J. Oliveira
2/16/2017
Animals; Calcium-Binding Proteins; Calpain; Cattle; Gene frequency; Genetic markers; Genotype; Polymorphism, Single Nucleotide; Quantitative trait loci; Red Meat

The objectives of this study were to characterize the allelic and genotypic frequencies of polymorphisms in the µ-calpain and calpastatin genes, and to assess their association with meat tenderness and animal growth in Nellore cattle. We evaluated 605 Nellore animals at 24 months of age, on average, at slaughter. The polymorphisms were determined for the molecular markers CAPN316, CAPN530, ... more

M.E. Carvalho; J.P. Eler; M.N. Bonin; F.M. Rezende; F.H. Biase; F.V. Meirelles; L.C.A. Regitano; L.L. Coutinho; J.C.C. Balieiro; J.B.S. Ferraz
3/22/2017
Abdominal fat; Animals; Body weight; Bone Density; Chickens; Core Binding Factor Alpha 1 Subunit; Femur; Genetic association studies; meat; Polymorphism, Single Nucleotide; RANK Ligand; Selection, Genetic

Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. ... more

N.V. Grupioni; N.B. Stafuzza; A.B. Carvajal; A.M.G. Ibelli; J.O. Peixoto; M.C. Ledur; D.P. Munari
3/22/2017
Animals; Bayes Theorem; Breeding; Genetic markers; Genomics; Genotype; Models, Genetic; Polymorphism, Single Nucleotide; Predictive Value of Tests; Quantitative trait loci; Regression Analysis; Selection, Genetic

Genomic selection (GS) is a variant of marker-assisted selection, in which genetic markers covering the whole genome predict individual genetic merits for breeding. GS increases the accuracy of breeding values (BV) prediction. Although a variety of statistical models have been proposed to estimate BV in GS, few methodologies have examined statistical challenges based on non-normal phenotypic ... more

M. Nascimento; F.F.E. Silva; M.D.V. de Resende; C.D. Cruz; A.C.C. Nascimento; J.M.S. Viana; C.F. Azevedo; L.M.A. Barroso
4/13/2017
Animals; Body composition; Body size; Breeding; Cattle; Genome-wide association study; Genotype; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable

In arid and semi-arid zones, animal health and production are closely correlated with body conformation traits. These selected traits, in turn, allow livestock to adapt unfavorable soil and environmental conditions. The primary objective of this study was to perform a genome-wide association analysis for a set of sampled and imputed SNPs with 16 conformation traits in a population of Holstein ... more

M.E. González; V.M. González; M.F. Montaño; G.E. Medina; P. Mahadevan; C. Villa; R. Villa
5/04/2017
Eucalyptus; Genetic Speciation; Genetic variation; Phylogeny; Polymorphism, Single Nucleotide; Psidium

The goal of this study was to analyze the genetic divergence among Psidium species accessions based on SNPs developed for Eucalyptus. Fifty-three Psidium accessions, including 47 P. guajava, were genotyped with EUCHIP60K. The dendrogram similarity ranged from 0.58 to 1.00, with a cophenetic value of 0.97. Five groups were identified at dendrogram cut point of 0.7: the first with 44 guava ... more

S.R. Costa; C.A.F. Santos

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