Research Article

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Animals; Apoptosis; Blood glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ginsenosides; Glucose; Insulin; JNK Mitogen-Activated Protein Kinases; Lipids; Liver; Liver Diseases; male; Random Allocation; Rats; Rats, Sprague-Dawley

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, ... more

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Animals; Brain; Cloning, Molecular; Fish Proteins; Fishes; Kidney; Liver; Muscle, Skeletal; Receptors, Glucocorticoid; Sodium Chloride; Stress, Physiological

To understand the regulation of the glucocorticoid receptor gene (Gcr) during loading and transport stress in fish, the Gcr gene of Coilia nasus was cloned. Gcr in C. nasus is expressed strongly in the liver and muscle, and less stronglyin the gills, brain, spleen, intestine, trunk kidney, and head kidney. Gcr expression in both the liver and muscle was increased by loading and transport ... more

F.K. Du; G.C. Xu; Y. Li; Z.J. Nie; P. Xu
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Animals; Cadmium; Cadmium Poisoning; Eels; Fish Proteins; Fresh Water; Liver; Metallothionein; Thailand; Water Pollution, Chemical

Cadmium (Cd) is produced mainly as a by-product of zinc mining. In Thailand, the largest zinc mine is located in the Mae Sot district, Tak Province. Samples of Monopterus albus were collected from paddy fields in 4 sites, three downstream and one upstream from the zinc mine. The upstream site was considered to be uncontaminated while the three downstream sites were considered to be ... more

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With the expanding demand for genetically modified (GM) rice, its safety evaluation is of great significance. Therefore, this study was carried out to assess the acute cytotoxicity of the whole protein extract from GM rice Bar68-1 in Mus musculus lymphocytes in vitro. Cell viability was determined by Cell Counting Kit-8 (CCK-8) and Neutral Red Uptake (NRU) tests. CCK-8 tests was carried out ... more

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Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Thus, for the present research, we examined the role of G protein- ... more

Y. Xing; Y. Gu; X. Shan; L. Wang; J. You
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Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

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1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Colorectal neoplasms; Dietary Supplements; DNA damage; Intestinal Mucosa; male; Mice; Probiotics; Yogurt

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a ... more

S.M.A. Limeiras; F.M. Ogo; L.A.L. Genez; C.M. Carreira; E.J.T. Oliveira; L.R. Pessatto; S.C. Neves; J.R. Pesarini; L.C. Schweich; R.A. Silva; W.B. Cantero; A.C.M.B. Antoniolli-Silva; R.J. Oliveira
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Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. Twenty-three volatile compounds were identified via gas chromatography-mass ... more

R.M. Oliveira; T.S. Dutra; E. Simionatto; N. Ré; C.A.L. Kassuya; C.A.L. Cardoso
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Amyotrophic lateral sclerosis; Animals; Cell line; DNA-Binding Proteins; MafK Transcription Factor; Mice; Mutation, Missense; NAD(P)H Dehydrogenase (Quinone); Neurons; NF-E2-Related Factor 2; Oxidative stress; Repressor Proteins; Response Elements

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects motor neurons and lacks an effective treatment. The disease pathogenesis has not been clarified at present. Pathological transactive response DNA-binding protein 43 (TDP-43) plays an important role in the pathogenesis of ALS. Nuclear translocation of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is ... more

Y.P. Tian; F.Y. Che; Q.P. Su; Y.C. Lu; C.P. You; L.M. Huang; S.G. Wang; L. Wang; J.X. Yu
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Four Hyriopsis cumingii populations, a breeding population (BP), a cultured population (FP), two wild populations from Poyang Lake (PY) and Dongting Lake (DT), and an H. schlegelii population were collected (JX), and the first filial generations (F1) were bred synchronously. The shell nacre polymorphisms, population genetic diversity, and genetic structures of the F1 of each population were ... more

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