Research Article

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2017 Jan 23
Antiviral Agents; Brazil; Fever; Genotype; HIV Infections; Humans; Incidence; Pyrophosphatases; Zidovudine

Zidovudine, the antiretroviral drug used to treat HIV infection, commonly causes adverse effects, such as systemic fever and gastrointestinal alterations. In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) of HIV with zidovudine was discussed. Individuals from Northeastern ... more

A.V.C. Coelho; S.P.S. Silva; L. Zandonà; G. Stocco; G. Decorti; S. Crovella
Alleles; environment; Gene-Environment Interaction; Genetic association studies; Genetic predisposition to disease; Genotype; Glutathione S-Transferase pi; Glutathione transferase; Humans; Polymorphism, Genetic; Stomach neoplasms

Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of ... more

Z.H. Chen; J.F. Xian; L.P. Luo
Alleles; Brazil; Genetic variation; Genotype; Phenotype; Quantitative Trait, Heritable; Saccharum; Selection, Genetic; Time Factors

The aim of this study was to analyze sugarcane (Saccharum officinarum) biometric and technological data, obtained at different timepoints, using path analysis. The experiment was conducted in União, PI, Brazil, and evaluated 12 sugarcane genotypes (RB036066, RB9438, RB935744, RB021764, RB021754, RB021534, RB966229, RB977540, RB863129, and RB987935, and the varieties RB92579 and RB867515 as ... more

R.P. Barbosa; A. Neto; L.M. Gravina; G.A. Gravina; M.G.T. Portela; A.A.C. Bezerra
Alleles; Asian Continental Ancestry Group; Case-control studies; China; Connexins; Deafness; Female; Genotype; Humans; Odds Ratio; Polymorphism, Genetic; Pregnancy; Risk; Sequence Deletion

Congenital deafness is a serious and irreversible condition in humans. The GJB2 gene is implicated in the pathogenesis of autosomal recessive nonsyndromic hearing loss. Its 235delC and 30-35delG polymorphisms are reported to be associated with risk of hereditary deafness. However, the effect of the interaction between GJB2 235delC and 30-35delG and environmental factors on congenital deafness ... more

Y. Xiong; M. Zhong; J. Chen; Y.L. Yan; X.F. Lin; X. Li
cluster analysis; Disease resistance; Genetic variation; Genotype; Gossypium; Phenotype; Plant Diseases; Quantitative Trait, Heritable

In Pakistan, cotton crop has been under enormous threat of cotton leaf curl disease (CLCuD) over the last four decades. In order to estimate genetic diversity in cotton germplasm CLCuD resistance, we assessed 100 cotton genotypes for their CLCuD resistance/tolerance and other related agronomical traits. Various statistical analytical tools, including correlation analysis, cluster analysis, and ... more

M. Javed; S.B. Hussain; M. Baber
Brazil; Breeding; Crosses, Genetic; Fusarium; Genetic variation; Genotype; Multivariate analysis; Plant Diseases; Tracheophyta

The multivariate analyses are useful tools to estimate the genetic variability between accessions. In the breeding programs, the Ward-Modified Location Model (MLM) multivariate method has been a powerful strategy to quantify variability using quantitative and qualitative variables simultaneously. The present study was proposed in view of the dearth of information about popcorn breeding ... more

R.N.F. Kurosawa; A.T. do Amara Junior; F.H.L. Silva; D. Santos; M. Vivas; S.H. Kamphorst; G.F. Pena
Brazil; Breeding; Crosses, Genetic; Genetics, Population; Genotype; Phenotype; Zea mays

In Brazil, the total production of maize has increased continuously due to the advances in technology but also to the new frontiers for the maize crop, including the expansion of the second crop (safrinha; usually maize after soybean). Therefore, the exploitation of new sources of germplasm seems to be imperative to attend the actual and future demands for modern cultivars adapted to the ... more

C.M. Silva; J.B.Miranda Filho; U.C. Mendes; E.F. Reis
Breeding; Crosses, Genetic; Disease resistance; Genetic variation; Genotype; Gossypium; Phenotype; Quantitative Trait, Heritable

Studying genetic diversity among a group of genotypes is important in genetic breeding because identifying hybrid combinations of greater heterotic effect also increases the chance of obtaining plants with favorable allele combinations in an intra-population selection program. The objective of this study was to compare different types of long and extra-long staple cotton and their genetic ... more

L.P. de Carvalho; F.J.C. Farias; J.I.S. Rodrigues; N.D. Suassuna; P.E. Teodoro
Camellia; cluster analysis; DNA, Plant; Genetic variation; Genotype; Microsatellite Repeats; Phylogeny

Camellia japonica produces different color and bigger flowers, widely being used for gardening green in southern China. However, cultivars were introduced from different regions, but their origin and pedigree information is either not available poorly documented, causing problems in authentication. Many low-yield trees in Camellia oleifera forests have been used as stocks for grafting C. ... more

Y. Zhao; C.J. Ruan; G.J. Ding; S. Mopper
Adult; DNA, Viral; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Host-Pathogen Interactions; Humans; male; Middle Aged; Polymerase chain reaction; Sequence Analysis, DNA; Virus Activation; Virus Replication; Young Adult

Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clinical, and laboratory data from 124,865 patients with chronic CHB ... more

Y. Xiang; P. Chen; J.R. Xia; L.P. Zhang