Research Article

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Animals; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Feces; Humans; Molecular Diagnostic Techniques; Multiplex polymerase chain reaction; Sensitivity and Specificity; Water Microbiology

Diarrhea is considered the second most common cause of infant mortality worldwide. The disease can be caused by many different pathogens, including diarrheagenic Escherichia coli (DEC), which includes the pathotypes enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), enteroaggregative E. coli (EAEC), Shiga toxin-producing E. coli (STEC), and enteropathogenic E. coli (EPEC). To ... more

J.W. Vendruscolo; T.L. Waldrich; G.I.A. Saikawa; J.S. Pelayo; R.K.T. Kobayashi; G. Nakazato; S.P.D. Rocha
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Apolipoproteins B; Brazil; Genetic testing; Humans; Hyperlipoproteinemia Type II; Introns; Mutation, Missense; Proprotein Convertase 9; Receptors, LDL

Familial hypercholesterolemia (FH) is a dominant, autosomal disease characterized by high LDL levels in blood plasma, and is caused by a defect in the gene encoding the LDL receptor (LDLR). The clinical diagnosis is based on personal and familial history, physical examination findings, and measures of high LDL cholesterol concentrations. LDLR is a cell-surface glycoprotein that controls the ... more

G.A. Molfetta; D.L. Zanette; J.E. Santos; W.A. Silva
08/31/2017
Cell Line, Tumor; Cell Movement; Cell proliferation; Down-regulation; Glioma; Humans; MicroRNAs

Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regulate glioma remains unknown. Thus, we investigated the effect of miR-1 ... more

Y.Q. Wang; Y. Cai; X.M. Zhong
09/27/2017
Acyclic Monoterpenes; DNA damage; Hep G2 Cells; Humans; Monocytes; Terpenes

Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations, this study was designed to ... more

T.B. Queiroz; G.F. Santos; S.C. Ventura; C.A. Hiruma-Lima; I.O.M. Gaivão; E.L. Maistro
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Ecuador; Gene frequency; Humans; Microsatellite Repeats; Polymorphism, Genetic; Population

One hundred and eighty-two samples of unrelated people who requested the paternity test at the Molecular Biology and Genetics Laboratory of the Catholic University of Cuenca-Ecuador in the province of Azuay were studied, except for the D1S1656 (180 samples) and SE33 (89 samples) markers. The STRs D22S1045, D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01, FGA, D1S1656, ... more

P.P. Orellana; C.F. Andrade; C.L. Arciniegas; G.C. Iannacone
09/21/2017
Animals; Biomarkers, Tumor; Conserved sequence; Helminth Proteins; Protein Binding; Protein domains; Protein stability; Sequence Homology; Tumor Protein, Translationally-Controlled 1; Tylenchoidea

Plant parasitic nematodes infect a wide range of hosts representing the largest source of biotic stress experienced by plants. Meloidogyne genus comprises the most important parasitic nematodes, also known as root-knot nematodes. These parasitic organisms obtain nutrients to support their development through complex interactions with their hosts. The translationally-controlled tumor protein ( ... more

R.M.Moraes Filho; A.F. Menezes; L.S.S. Martins

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