Research Article

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2/8/2017
Alleles; environment; Gene-Environment Interaction; Genetic association studies; Genetic predisposition to disease; Genotype; Glutathione S-Transferase pi; Glutathione transferase; Humans; Polymorphism, Genetic; Stomach neoplasms

Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of ... more

Z.H. Chen; J.F. Xian; L.P. Luo
2/8/2017
alpha-Fetoproteins; Animals; Disease Models, Animal; Gene expression; Glypicans; Humans; Liver neoplasms; male; Neoplasm Micrometastasis; Polymerase chain reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger

The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could be used to determine the presence of malignant cells. The nested ... more

J. Luo; K. Yang; Y.G. Wen
2/8/2017
Alleles; Asian Continental Ancestry Group; Case-control studies; China; Connexins; Deafness; Female; Genotype; Humans; Odds Ratio; Polymorphism, Genetic; Pregnancy; Risk; Sequence Deletion

Congenital deafness is a serious and irreversible condition in humans. The GJB2 gene is implicated in the pathogenesis of autosomal recessive nonsyndromic hearing loss. Its 235delC and 30-35delG polymorphisms are reported to be associated with risk of hereditary deafness. However, the effect of the interaction between GJB2 235delC and 30-35delG and environmental factors on congenital deafness ... more

Y. Xiong; M. Zhong; J. Chen; Y.L. Yan; X.F. Lin; X. Li
2/8/2017
Animals; DNA damage; DNA Fragmentation; Female; Ferric Compounds; Humans; Lipid peroxidation; Lymphocytes; Metal Nanoparticles; Oxidative stress; Rats; Reactive oxygen species; Silicon Dioxide

At present, the use of nanoparticles is a controversial topic, especially when analyzing their effects in human tissues. Nanoparticles (NPs) can cause oxidative stress by increasing membrane lipids peroxidation and reactive oxygen species, and decreasing intracellular glutathione. Oxidative stress plays an important role in cell signaling and inflammatory responses. It can result in ... more

J. Jiménez-Villarreal; D.I. Rivas-Armendáriz; R.D.Arellano Pérez-Vertti; O. Calderón; R. García-Garza; N.D. Betancourt-Martínez; L.B. Serrano-Gallardo; J. Morán-Martínez
2/8/2017
Breast neoplasms; Female; Gene expression; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Staging; Prognosis

Migration and invasion enhancer 1 (MIEN1) is a membrane-anchored protein that is highly expressed in various types of cancer, and is correlated with the PI3K/AKT pathway. The aim of this study was to investigate the expression of MIEN1 and its clinical pathological significance in breast cancer. We used immunohistochemical staining to examine the expression of MIEN1 in 40 samples of human ... more

H.B. Zhao; X.F. Zhang; H.B. Wang; M.Z. Zhang
2/8/2017
Developing Countries; Genetic Diseases, Inborn; Genetic testing; Humans; Mass Screening; Population Surveillance; Socioeconomic Factors

The aim of this review is to describe a series of ten genetic diseases with Mendelian inheritance pattern in people of low- or middle-income countries, which can be easily identified with simple and affordable methods. Recent information shows that although genetic diseases account for more than 10% of infant mortality in such countries, testing, counseling, and treatment of genetic diseases ... more

P.E. Maltese; E. Poplavskaia; I. Malyutkina; F. Sirocco; A. Bonizzato; N. Capodicasa; S.Y. Nicoulina; A. Salmina; N. Aksutina; M. Dundar; T. Beccari; S. Cecchin; M. Bertelli
2/16/2017
Adolescent; Adult; Aged; Case-control studies; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Genotype; Humans; Interferon-gamma; Introns; male; Middle Aged; Multiple sclerosis; Polymorphism, Single Nucleotide; Young Adult

The present study aims to examine the relationship between polymorphisms in the third intron of the IFN-γ gene and their influence on susceptibility to multiple sclerosis. A population-based case-control study was used for this purpose. Multiple sclerosis patients and healthy controls were interviewed. Genetic polymorphisms of IFN-γ intron III at the +2118 A/G and +3586 G/ACT sites were ... more

X.L. Wang; F.R. Meng; X. Wang; S.H. Wang; L. Guo
2/16/2017
Asian Continental Ancestry Group; Case-control studies; Coronary artery disease; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Humans; Interleukin-8; male; Polymorphism, Single Nucleotide

Interleukin-8 (IL-8) is a mediator of inflammation and plays an important role in regulating immune responses. To date, several studies have tested the association between IL-8 gene polymorphisms and development of coronary artery disease (CAD), but their results have proved to be inconsistent. We conducted an investigation to assess the relationship between the IL-8 -251A/T (rs4073) sequence ... more

R.J. Zhang; X.D. Li; S.W. Zhang; X.H. Li; L. Wu
2/16/2017
Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang
2/16/2017
Cell differentiation; Colorectal neoplasms; Down-regulation; Female; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Kruppel-Like Transcription Factors; Lymphatic metastasis; male; Prognosis; Survival analysis

Kruppel-like factors (KLFs) are a group of transcriptional regulators that have recently been identified to exhibit tumor-suppressive function against various gastrointestinal cancers. The present study aims to investigate the expression patterns and prognostic value of KLF-4 in colorectal cancers (CRCs). KLF-4 levels in CRC tissues were examined via immunohistochemistry analysis, real-time ... more

D.H. Xiu; Y. Chen; L. Liu; H.S. Yang; G.F. Liu

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