Research Article

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1/23/2017
Gene expression; Humans; Parkinson disease; Prion Proteins; REM Sleep Behavior Disorder; RNA, Messenger

Parkinson's disease (PD) is one of the most common neurodegenerative diseases and mainly manifests with decreasing numbers of dopaminergic neurons. Rapid eye movement (REM) sleep behavior disorder (RBD) has an incidence of 15-47% in all PD patients. Prion proteins (PrPs), which are expressed in both neurons and glial cells of the brain, are believed to be correlated with abnormal neurological ... more

W.J. Zhang; X.L. Shang; J. Peng; M.H. Zhou; W.J. Sun
1/23/2017
Case-control studies; Cerebral infarction; Diffusion Tensor Imaging; Humans; Wallerian Degeneration

This study aimed to evaluate the clinical significance of diffusion tensor imaging (DTI) in the early diagnosis of pyramidal tract Wallerian degeneration (WD) and assessment of neurological recovery following cerebral infarction. This study included 23 patients with acute cerebral infarction and 10 healthy adult controls. All participants underwent both magnetic resonance imaging (MRI) and DTI ... more

A.H. Guo; F.L. Hao; L.F. Liu; B.J. Wang; X.F. Jiang
1/23/2017
Female; Genetic predisposition to disease; High-Throughput Nucleotide Sequencing; Humans; Macular Degeneration; male; Proteins; Risk; Turkey

Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. It is a complex disease with both genetic and environmental risk factors. To improve clinical management of this condition, it is important to develop risk assessment and prevention strategies for environmental influences, and establish a more effective treatment approach. The aim of the present ... more

H. Bardak; M. Gunay; Y. Ercalik; Y. Bardak; H. Ozbas; O. Bagci
1/23/2017
Brazil; Chromosome Disorders; Chromosome duplication; Chromosomes, Human, Pair 5; Humans; male; Phenotype

Genomic disorders are genetic diseases that are caused by rearrangements of chromosomal material via deletions, duplications, and inversions of unique genomic segments at specific regions. Such rearrangements could result from recurrent non-allelic homologous recombination between low copy repeats. In cases where the breakpoints flank the low copy repeats, deletion of chromosomal segments is ... more

F.G. Reis; I.P. Pinto; L.B. Minasi; A.V. Melo; D.M. da C. Cunha; C.L. Ribeiro; C.C. da Silva; deM. Silva; A.D. da Cruz
1/23/2017
Alleles; Colorectal neoplasms; Genetic association studies; Genetic predisposition to disease; Genotype; Humans; Mexico; Odds Ratio; Polymorphism, Single Nucleotide; PPAR delta

PPARD encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. Accumulated evidence suggests that the polymorphism rs2016520 in PPARD is associated with lipid metabolism, obesity, metabolic syndrome, and type 2 diabetes mellitus. The aim of this study ... more

M.A. Rosales-Reynoso; L.I. Wence-Chavez; A.R. Arredondo-Valdez; S. Dumois-Petersen; P. Barros-Núñez; M.P. Gallegos-Arreola; S.E. Flores-Martínez; J. Sánchez-Corona
1/23/2017
Animals; Cognition Disorders; Disease Models, Animal; Gene expression; Hippocampus; HIV Envelope Protein gp120; Humans; Immunohistochemistry; Maze Learning; Rats; Receptors, Purinergic P2X7

To investigate the role of the P2X receptor in learning and memory dysfunction induced by HIV-1 envelope glycoprotein gp120 (gp120), we established HIV-1-associated dementia (HAD) animal models by intracerebroventricular (ICV) infusion of gp120 in rats. We observed gp120-induced cognitive dysfunction in the radial arm water maze test. Results showed that rats in the gp120 groups had longer ... more

Y. Liu; G.Q. Chen; B.Y. Liu; Q. Chen; Y.M. Qian; S.S. Qin; C.L. Liu; C.S. Xu
1/23/2017
5' Untranslated Regions; Argentina; Genetic variation; Genetics, Population; Humans; Thymidylate synthase

Thymidylate synthase (TYMS) is a key enzyme in nucleotide synthesis and therefore, an important target of many chemotherapeutic agents. Expression of TYMS mRNA is thought to be modulated by a 28-bp tandem repeat polymorphism within its 5'-untranslated region, raising the question of this variant's utility in predicting the efficacy and toxicity of cancer treatment regimens. The aim of the ... more

C. Vázquez; M. Orlova; P. Scibona; D. Arce; M.G. Pallotta; W.H. Belloso
1/23/2017
Antiviral Agents; Brazil; Fever; Genotype; HIV Infections; Humans; Incidence; Pyrophosphatases; Zidovudine

Zidovudine, the antiretroviral drug used to treat HIV infection, commonly causes adverse effects, such as systemic fever and gastrointestinal alterations. In the present study, the potential role of inosine triphosphate pyrophosphatase (ITPA) gene variant on the incidence of adverse events during antiretroviral therapy (ART) of HIV with zidovudine was discussed. Individuals from Northeastern ... more

A.V.C. Coelho; S.P.S. Silva; L. Zandonà; G. Stocco; G. Decorti; S. Crovella
1/23/2017
Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell proliferation; Cell survival; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms; RNA, Long Noncoding

The objective of this study was to investigate the effect of downregulating long non-coding RNAs (lncRNAs) on the reversal of cisplatin resistance in CP70 ovarian cancer cells, and to identify the underlying mechanism(s) of action. An lncRNA microarray was performed to screen for downregulated lncRNAs in cisplatin-resistant CP70 cells. Expression levels of these lncRNAs were then verified in ... more

H. Yan; J.Y. Xia; F.Z. Feng
1/23/2017
Biomarkers, Tumor; Colonic Neoplasms; Humans; Models, Theoretical; Reproducibility of Results; Support vector machine

We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of the model was checked. High accuracy was assumed to indicate the ... more

W.Y. Yang; G. Shi; L.P. Wu; S.T. Wei; Y.N. Huang; L.X. Tan; R.Z. Yang; C.X. Yan; E.T. Guo; H.Y. Wang; J.Z. Tong; Y. Dong; D.Z. Han

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