Research Article

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2/8/2017
Animals; Avian Proteins; Chickens; Disease resistance; Gene expression; Immunity, Innate; Protein Interaction Domains and Motifs; Signal transduction; TNF Receptor-Associated Factor 6

Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. The function of TRAF6 has been clarified in mammals but is poorly understood in chicken. In our study, we investigated TRAF6 function in birds, particularly ... more

J. Jin; J.S. Ran; C.W. Yang; X.S. Jiang; Y.G. Zhou; Z.Q. Feng; Y. Wang; D. Lan; P. Ren; Y.P. Liu
3/8/2017
Adaptation, Physiological; Arachis; Calcium-Binding Proteins; Droughts; Plant Leaves; Plant Proteins; Plants, Genetically Modified; rab GTP-Binding Proteins; Salinity; Salt-Tolerant Plants; Signal transduction; Stress, Physiological; Transcription factors

The Rab protein family is the largest family of the small GTP-binding proteins. Among them, the RabG genes are known to be responsive to abiotic stresses, but the molecular mechanisms of the stress responses mediated by RabG genes in plants is poorly understood. To investigate the molecular mechanism of AhRabG gene in peanut, transgenic plants overexpressing the AhRabG gene (S6) with ... more

J.M. Sui; G. Li; G.X. Chen; M.Y. Yu; S.T. Ding; J.S. Wang; L.X. Qiao
12/19/2016
Adult; Arthritis, Rheumatoid; Female; Genetic predisposition to disease; Hand; Hand Injuries; Humans; Interleukin-6; male; Mexico; Middle Aged; Polymorphism, Single Nucleotide

Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JBA). The objective of the present study was to evaluate the ... more

S.A. Zavaleta-Muñiz; L. Gonzalez-Lopez; J.D. Murillo-Vazquez; A.M. Saldaña-Cruz; M.L. Vazquez-Villegas; B.T. Martín-Márquez; J.C. Vasquez-Jimenez; F. Sandoval-Garcia; A.J. Ruiz-Padilla; N.S. Fajardo-Robledo; J.M. Ponce-Guarneros; A.D. Rocha-Muñoz; M.F. Alcaraz-Lopez; D. Cardona-Müller; S.E. Totsuka-Sutto; E.D. Rubio-Arellano; J.I. Gamez-Nava
12/19/2016
Computational biology; Gene Regulatory Networks; Humans; Models, Genetic; Models, Statistical; Translational Medical Research

A salient problem in translational genomics is the use of gene regulatory networks to determine therapeutic intervention strategies. Theoretically, in a complete network, the optimal policy performs better than the suboptimal policy. However, this theory may not hold if we intervene in a system based on a control policy derived from imprecise inferred networks, especially in the small-sample ... more

X.Z. Zan; W.B. Liu; M.X. Hu; L.Z. Shen
03/11/2013
ERK1/2 signaling pathway; Gene expression profiling; Gene synergy; Liver cell types; Liver restoration

It has been well established that ERK1/2 signaling, often subdivided into nine types of pathways, can regulate the hepatocyte proliferative response during liver regeneration. However, the effect of ERK1/2 signaling on the proliferation of other hepatic cell types remains unclear. We isolated and purified 8 liver cell types at 10 time points after 2/3 hepatectomy in adult rats. For each ... more

X.G. Chen; C.S. Xu; Y.M. Liu
09/26/2014
Amur tiger; Gene expression profiling; ITL-2; PEG10; PLAC8; Placenta

The Amur tiger is a unique endangered species in the world, and thus, protection of its genetic resources is extremely important. In this study, an Amur tiger placenta cDNA library was constructed using the SMART cDNA Library Construction kit. A total of 508 colonies were sequenced, in which 205 (76%) genes were annotated and mapped to 74 KEGG pathways, including 29 metabolism, 29 genetic ... more

Q. Li; T.F. Lu; D. Liu; P.F. Hu; B. Sun; J.Z. Ma; W.J. Wang; K.F. Wang; W.X. Zhang; J. Chen; W.J. Guan; Y.H. Ma; M.H. Zhang
09/26/2014
Beef cattle; Gibbs sampling; Monte Carlo method; Threshold models

Finishing precocity visual score selection was adopted to estimate the time from birth to reach slaughter age. This study estimated (co)variance components and genetic correlations for the finishing precocity score at weaning (WP) and yearling (YP) stages by using daily weight gain (BWG = from birth to weaning; WYG = from weaning to yearling) and speed of weight gain (BWR = from birth to ... more

D.M. Everling; T. Bresolin; P.R.N. Rorato; R.O. Araujo; A.A. Boligon; T. Weber; M.A. Dornelles; L.T. Campos
09/01/2015
Docking; Interactome; Pharmacophore modeling; Ser/Thr protein kinase; Signal transduction

Tuberculosis continues to be a major cause of mortality worldwide despite significant advances in chemotherapy and development of the BCG vaccine. Although curable, the tuberculosis treatment period (6-9 months) presents many concerns, including patient noncompliance and the development of drug toxicity and drug resistance. This study aimed to understand the protein-protein interactions ... more

A.B. Gurung; B.J. Mylliemngap; A. Bhattacharjee; M.A. Ali; F.M.A. Al-Hemaid
09/22/2015
Genetic diversity; Genic-SSRs; Nelumbo nucifera; Transcriptome

Nelumbo nucifera is an important economic vegetable and traditional medicine, but available genetic resources remain limited. Next generation sequencing has proven to be a rapid and effective means of identifying genic simple sequence repeat (genic-SSR) markers. This study developed genic-SSRs for N. nucifera using Illumina sequencing technology to assess diversity across ... more

X.F. Zheng; Y.N. You; Y. Diao; X.W. Zheng; K.Q. Xie; M.Q. Zhou; Z.L. Hu; Y.W. Wang
07/28/2015
Heat shock protein; high temperature; Transcriptome; Tree peony leaf

The tree peony leaf is an important vegetative organ that is sensitive to abiotic stress and particularly to high temperature. This sensitivity affects plant growth and restricts tree peony distribution. However, the transcriptomic information currently available on the peony leaf in public databases is limited. In this study, we sequenced the transcriptomes of peony leaves subjected to ... more

Y.Z. Zhang; Y.W. Cheng; H.Y. Ya; J.M. Han; L. Zheng

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