Research Article

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12/04/2013
Chinese Han population; Hypertension; Single nucleotide polymorphism

Human hypertension is a complex, multifactorial disease. Multiple variants associated with hypertension have been identified in the large numbers of genome-wide association studies, meta-analysis, and case-control studies. The present study investigated the association between the single nucleotide polymorphisms (SNPs) of five candidate genes and the susceptibility and prognosis of ... more

G.L. Hong; X.Z. Chen; Y. Liu; Y.H. Liu; X. Fu; S.B. Lin; Q. Zhu
07/07/2014
Cardiac remodeling; Diastolic function; High-sensitivity troponin T; Hypertension

It has been well established that high-sensitivity cardiac troponin T (hs-TnT) is a specific and highly sensitive marker in acute coronary syndromes. On the other hand, studies on serum concentrations of hs-TnT in patients with hypertension in the absence of significant coronary stenosis are limited. Therefore, we hypothesized that hs-TnT levels are related to left ventricular (LV) ... more

D.M. Miao; L.P. Zhang; H.P. Yu; J.Y. Zhang; W.K. Xiao; P. Ye
05/11/2015
Carotid artery intima-media thickness; Hypertension; Serum sulfatide

Hypertension is a major traditional risk factor for atherosclerosis, and carotid artery intima-media thickness (IMT) is considered to be an important marker of atherosclerosis. Sulfatides have been shown to play a role in atherogenesis and vascular inflammation, resulting in atherosclerosis. This study aimed to assess the association between serum sulfatide and carotid artery IMT among ... more

G. Li; R. Hu; J. Gu; H.Z. Wu
09/21/2015
c-Jun N-terminal kinases; CAAT/enhanced I-binding protein; Endoplasmic reticulum stress; Hypertension; Ischemia/reperfusion

Acute brain ischemia can induce the activation of c-Jun N-terminal kinases (JNKs). Hypertension is a critical etiology for brain ischemia. We identified the effects of hypertension on the activation of JNK as well as its impact on SP600125, a JNK inhibitor, during endoplasmic reticulum stress (ERS) in the hippocampus using a rat model. Transient whole-brain ischemia was induced by 4- ... more

Y.N. Zhao; J.M. Li; C.X. Chen; P. Zhang; S.X. Li
08/21/2015
Haplotype; Hypertension; Mongolian; SLC12A3; TagSNP

Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotyping. The genotype ... more

J.Q. Liang; Y.G. Xi; C.Y. An; X.L. Su
12/05/2003
Dynamic mutation; Genetic polymorphism; SCA1; SCA2; Spinocerebellar ataxia

Dynamic mutation involves the expansion of a tandem arrayed DNA sequence that is polymorphic in the population. This mechanism is associated with neurological/neuromuscular disorders and the pathology depends on the extension of the repeated tract, with a specific threshold for each disease. We made a PCR-based characterization of allelic polymorphism of SCA1 and SCA2 loci in a sample of 200 ... more

S.F.P. Duarte; R.S. Gestinari; M. Campos-Jr.; M.M.G. Pimentel; M.A.Costa Lima
10/05/2007
Genetic polymorphism; Leptin; Leptin receptor; Obesity; β3-adrenergic receptor

Obesity is due to the combined effects of genes, environment, lifestyle, and the interactions of these factors. The adrenergic receptor β3 (β3-AR), leptin (LEP) and leptin receptor (LEPR) genes have been intensively evaluated in the search of variants that could be related to obesity and its cardiometabolic complications. The results of most of these studies have ... more

S.F.P. Duarte; E.A. Francischetti; V.A. Genelhu; P.H. Cabello; M.M.G. Pimentel
01/22/2008
Down syndrome; Genetic polymorphism; Nondisjunction; Trisomy 21

The aim of the present study was to investigate the effect of polymorphisms C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, A2756G in methionine synthase reductase (MTR) gene and A80G in reduced folate carrier 1 (RFC1) gene, and plasma homocysteine (Hcy), on the maternal risk for Down syndrome (DS). Seventy-two DS mothers and 194 mothers who ... more

J.M. Biselli; E.M. Goloni-Bertollo; B.L. Zampieri; R. Haddad; M.N. Eberlin; E.C. Pavarino-Bertelli
05/17/2011
Acid phosphatase locus 1; Favism; Genetic polymorphism; Glucose-6-phosphate dehydrogenase deficiency; LMW protein tyrosine phosphatases

An association between favism (a hemolytic reaction to consumption of fava beans), glucose-6-phosphate dehydrogenase deficiency (G6PD-) and acid phosphatase locus 1 (ACP1) phenotypes has been reported; the frequency of carriers of the pa and pc ACP1 alleles was found to be significantly higher in G6PD- individuals showing favism than in the general ... more

V. Polzonetti; V. Passini; N. Lucarini
02/03/2012
Children; Han; Henoch-Schonlein purpura; HLA-A; HLA-B; Mongolian

We examined a possible association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura (HSP) in Han and Mongolian children in Inner Mongolia, through a case-control study. Two hundred and sixty-eight unrelated children were enrolled, including 56 Mongolian and 50 Han children with HSP, 66 healthy Mongolian and 96 healthy Han children as a control group. HLA-A ... more

S.M. Ren; G.L. Yang; C.Z. Liu; C.X. Zhang; Q.H. Shou; S.F. Yu; W.C. Li; X.L. Su

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