Research Article

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02/28/2014
Genetic polymorphism; Lung cancer; Meta-analysis; rs401681 (G>A); TERT-CLPTM1L

A genome-wide association study revealed that a single nucleotide polymorphism, CLPTM1L - rs401681 (G>A), located at the 5p15.33 locus was significantly associated with increased risk of various cancers; however, its association with lung cancer is currently inconclusive. In order to explore the relationship between this polymorphism and lung cancer risk more precisely, we ... more

X.L. Zhang; X.J. Zhang; Y. Chen; Y.M. Zhang; Q. Zhang; C.X. Cao; D.Y. Gu; J.F. Shi; Y.L. Gong; J.F. Chen; C.J. Tang
06/11/2015
Genetic polymorphism; Male infertility; MDR1 (ABCB1); P-glycoprotein

Infertility affects 1 in 6 couples and approximately 1 in 25 men. Male factor infertility is a major cause of spermatogenic anomalies, the causes of which are largely unknown. Impaired repro­ductive functions in men might result from physiological, genetic, and/or environmental factors such as xenobiotics. The multi-drug re­sistance1 (MDR1) gene encodes a P-glycoprotein which has ... more

S.E. Aydos; A. Karadağ; T. Özkan; B. Altınok; M. Bunsuz; S. Heidargholizadeh; K. Aydos; A. Sunguroĝlu
06/11/2015
Genetic polymorphism; Genotype; Haplotype; Killer cell immunoglobulin-like receptor (KIR); Polymerase chain reaction-sequence specific primers

The aim of this study was to explore the genetic polymorphism, genotype, and haplotype characteristics of the KIR locus in the Xinjiang Han population in order to establish a foundation for future analysis of the relationship between KIR genes and disease. KIR genes were detected by sequence-specific primer-polymerase chain reaction in 184 randomly selected, ... more

G.Y. Lin; B. Yu; W.J. Hu; Y.Z. Zhang; X.J. Zuo; Y.B. Wang
06/01/2015
Genetic polymorphism; Microsatellite marker; Silver fox

The silver fox (Vulpes vulpes), a coat color variant of the red fox, is one of the most important fur-bearing animals. To date, development of microsatellite loci for the silver fox has been limited and mainly based on cross-amplification by using canine SSR primers. In this study, 28 polymorphic microsatellite markers were isolated and identified for silver fox through the ... more

S.Q. Yan; C.Y. Bai; S.M. Qi; Y.M. Li; W.J. Li; J.H. Sun
04/27/2015
Genetic polymorphism; Monocyte chemoattractant protein 1; Pulmonary tuberculosis

Pulmonary tuberculosis (PTB) remains one of the most important infectious diseases worldwide. Several studies have suggested that genetic factors may affect the susceptibility to PTB, but the specific genes involved have not been fully characterized. The gene for monocyte chemoattractant protein 1 (MCP-1) has been linked to an increased risk of tuberculosis in some Mexican and ... more

G.L. Shi; L. Yang; Y. Sun; Y.J. Yin; C.X. Song
04/10/2015
Genetic polymorphism; Glioma; PTGS2

Several previous studies indicated that genetic polymorphisms in inflammatory factor genes were associated with glioma risk. However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. We selected 199 histologically confirmed adult glioma patients and 199 cancer-free controls for ... more

R.P. Lin; C.Y. Yao; D.X. Ren
04/10/2015
Genetic polymorphism; PARK16; Parkinson’s disease

Recent genome-wide association studies identified 11 risk loci in different populations of familial and sporadic Parkinson’s disease (PD) patients. Few loci have been verified in different European and Asian populations. We also validated 2 new single-nucleotide polymorphisms, rs947211 and rs823144, in PARK16 to explore their association with susceptibility to PD in the Xinjiang Uygur and Han ... more

H. Xia; Q. Luo; X.X. Li; X.L. Yang
03/30/2015
Colostrum; Fcgrt; Genetic polymorphism; IgG; Sheep

The neonatal Fc receptor (FcRn) plays an important role in regulating IgG homeostasis in the body and passive protection to the offspring. Changes in FcRn expression levels caused by genetic polymorphisms of Fcgrt, which encodes FcRn, may lead to inter-individual differences in colostrum IgG levels in sheep. In this study, we sequenced the FcRn partial heavy chain from 179 sheep ... more

Z.H. Tian; F. Shi; F.G. Zhong; D.P. Bai; X.Y. Zhang
03/30/2015
Genetic polymorphism; Meta-analysis; Overactive bladder risk; β3-adrenoceptor genes

Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we ... more

H.C. Qu; W. Zhang; Y.L. Liu; P. Wang
12/30/2004
Angiotensin I-converting enzyme; Bradykinin-potentiating peptides; Hypertension; Modeling; Molecular dynamics

Angiotensin I-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase expressed in endothelial, epithelial and neuroepithelial cells. It is composed of two domains, known as N- and C-domains, and it is primarily involved in blood pressure regulation. Although the physiological functions of ACE are not limited to its cardiovascular role, it has been an attractive target for drug design ... more

J.Hernandez Fernandez; G. Neshich; A.Carlos M. Camargo

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