Research Article

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07/27/2010
ABO blood system; Brazilian Amazon region; Genetic polymorphism; Malaria; Plasmodium falciparum

We investigated the ABO genotypes and heterogeneity of the O alleles in Plasmodium falciparum-infected and non-infected individuals from the Brazilian Amazon region. Sample collection took place from May 2003 to August 2005, from P. falciparum malaria patients from four endemic regions of the Brazilian Amazon. The control group consisted of donors from four ... more

D.B. Carvalho; L.C. de Mattos; W.C. Souza-Neiras; C.R. Bonini-Domingos; A.B. Cósimo; L.M. Storti-Melo; G.C. Cassiano; A.A.A. Couto; A.J. Cordeiro; A.R.B. Rossit; R.L.D. Machado
05/11/2010
Chronic obstructive pulmonary disease; Genetic polymorphism; Glutathione S-transferase

Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved in susceptibility to develop COPD. It belongs to the ... more

R. Lakhdar; S. Denden; J. Knani; N. Leban; H. Daimi; M. Hassine; G. Lefranc; J. Ben Chibani; H. Khelil
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Genetic polymorphism; Glioma; Glutathione S-transferases; Perillyl alcohol

GSTM1 (glutathione S-transferase mu 1) and GSTT1 (glutathione S-transferase theta 1) are critical enzymes for detoxification of endogenous and environmental carcinogens. Constitutive GST gene polymorphisms may be associated with increased risk for cancer development. We made an explorative study of a Brazilian population with malignant glioma to determine whether ... more

M.M. Silva; C.O. Da Fonseca; R. Moura-Neto; J.F. Carvalho; T. Quirico-Santos; M.G. Carvalho
04/02/2013
Genetic association; Genetic polymorphism; Holstein cows; Molecular markers

The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and ... more

J.C. Rincón; A. López-Herrera; J.J. Echeverri
11/28/2014
Genetic polymorphism; Hypodontia; Meta-analysis; Msh homeobox 1; Transforming growth factor-β1

We conducted a comprehensive meta-analysis of 4 case-control studies to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-β1 (TGF-β1) genes and hypodontia. A total of 643 tooth agenesis cases and 733 healthy controls were included in this study. The meta-analysis results showed that the T allele and T ... more

W. Zhang; H.C. Qu; Y. Zhang
11/28/2014
Genetic polymorphism; Hypodontia; Meta-analysis; PAX9

To evaluate the association between paired box 9 (PAX9) gene polymorphisms and tooth agenesis in isolated humans, we performed a comprehensive meta-analysis. We examined 6 case-control studies, with a total of 855 hypodontia cases and 1201 healthy controls. The G allele and G carrier (AG + GG) of A1031G were positively associated with hypodontia susceptibility. Similarly, the T ... more

W. Zhang; H.C. Qu; Y. Zhang
09/26/2014
Genetic polymorphism; Interleukin-10; Interleukin-6; Pulmonary tuberculosis

We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment ... more

F.M. Feng; X.X. Liu; Y.H. Sun; P. Zhang; S.F. Sun; B. Zhang; X.T. Wang; L.J. Lu
05/30/2014
Esophageal squamous cell carcinoma; Genetic polymorphism; IGFBP-3; Molecular epidemiology

Insulin-like growth factor binding protein-3 (IGFBP-3) exerts anti-proliferative or pro-apoptotic effects through IGF-dependent as well as IGF-independent mechanisms in vitro. The purpose of this study was to examine the association between genetic variants in IGFBP-3 (rs2270628) and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. Five ... more

H.P. Yang; J.F. Liu; J. Rao; X.M. Zhang; H.L. Qian; X.Q. Niu; Z.L. Zhao
05/09/2014
16S rRNA; COI; Crustacean; Genetic polymorphism; Genetic variability; Macrobrachium

The genus Macrobrachium includes prawns, which are widely distributed in lakes, floodplains, and rivers in tropical and subtropical regions of South America. This genus presents nearly 210 known species with great ecological and economic importance. However, few studies are related to the biology of these crustaceans. In this study, we analyzed the genetic variability and ... more

A.L. Guerra; A.V.B. Lima; R.V.Lucato Júnior; M.C. Chiachio; F.G. Taddei; L. Castiglioni
02/14/2014
Bone mineral density; Chinese women; Genetic polymorphism; Osteoporosis; Osteoprotegerin gene; Risk factor

Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442 age-matched healthy controls. The BMD at the femoral ... more

Y.P. Liu; D.W. Zhao; W.M. Wang; B.J. Wang; Y. Zhang; Z.G. Li

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