Research Article

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07/13/2015
Acute cerebral infarction; Apoptosis; Bcl-2

We aimed to investigate the influence of lentiviral-medi­ated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the treatment group received lentivirus ... more

H.R. Zhang; J.H. Peng; G.Y. Zhu; R.X. Xu
12/29/2015
Apoptosis; miR-126; Myocardial ischemia-reperfusion

Multiple studies have shown microRNAs to play an important role in disease occurrence and development. The role of miRNAs in ischemia-reperfusion injury, however, requires further investigation and the aim of this study was therefore to assess miR-126 expression in myocardial ischemia reperfusion and the effects of miR-126 on myocardial ischemia-reperfusion injury. An in vitro ... more

B. Li; Y. Tao; Q. Huang
12/22/2015
Apoptosis; Fas/FasL; Neurogenesis; Sevoflurane

Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure oxygen. Western blotting was used to ... more

Q. Song; Y.L. Ma; J.Q. Song; Q. Chen; G.S. Xia; J.Y. Ma; F. Feng; X.J. Fei; Q.M. Wang
12/17/2015
Acute leukemia; Apoptosis; Children; Interleukin-24; Mononuclear cell

To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro. Four groups were assessed: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-leukemia, and healthy groups, 20 children in each group. ELISA was used to measure IL-24 serum level. The bone ... more

H.R. Cheng; B.Q. Wu; L. Chen; Z.X. Zhang; B. Li
12/21/2015
Apoptosis; Biflorin; Cytotoxicity; O-naphthoquinone; Tumor

Biflorin is an o-naphthoquinone isolated from the roots of the plant Capraria biflora L. (Scrophulariaceae). In this study, the cytotoxic effects of biflorin were verified, and late apoptosis was detected in various cancer cell lines by in situ analysis. The cytotoxicity was further evaluated exclusively for 48 h of treatment in different tumor and non-tumor cell lines ( ... more

G.G.Nde S. Wisintainer; G. Scola; S. Moura; T.L.G. Lemos; C. Pessoa; M.O. de Moraes; L.G.S. Souza; M. Roesch-Ely; J.A.P. Henriques
12/11/2015
Afatinib; Apoptosis; Aquaporin-1; Cetuximab; Kinase domain receptor

In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 cells. A549 cells were cultured in ... more

Y.H. Liu; W.L. Zhu
12/11/2015
Apoptosis; Co-culture; Endometriotic cells; Human umbilical cord mesenchymal stem cells; Tensin homologue gene

The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group consisted of 1 x 10 ... more

L.N. Xu; N. Lin; B.N. Xu; J.B. Li; S.Q. Chen
12/09/2015
Apoptosis; Capecitabine (Xeloda); Non-small-cell lung cancer cell line A549; Radiation sensitive

The purpose of this study was to explore the radiotherapy sensitization effects and the mechanism of capecitabine (Xeloda) against the non-small-cell lung cancer cell line, A549. γ-[60Co] radiation was used as the intervention method. Proliferative inhibition of capecitabine on A549 cells was determined by the CCK-8 method. The effects of capecitabine on the apoptosis rate and ... more

J.J. Zhu; J.J. Shan; L.B. Sun; W.S. Qiu
11/30/2015
Apoptosis; HepG2 cell; Liver cancer; Wilfortrine

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We investigated the role of wilfortrine on liver cancer cell HepG2 ... more

M. Yue; X.J. Shen; Y.X. Liu; X.Y. Lin; S.Q. Zhou; Y.H. Song
12/02/2015
Apoptosis; Cytotoxicity; Dihydromyricetin; Gastric cancer; p53

The aim of the present study was to determine the anti­proliferative and pro-apoptotic effects of dihydromyricetin (DHM) on the AGS human gastric cancer cells and their underlying mechanisms. The effects of DHM on AGS cells were evaluated by using 3-(4, 5-di­methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase, and Annexin V/propidium iodide (PI) double- ... more

F.J. Ji; X.F. Tian; X.W. Liu; L.B. Fu; Y.Y. Wu; X.D. Fang; H.Y. Jin

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