Research Article

Related GMR Articles

Glioma; Single-nucleotide polymorphism; susceptibility; X-ray cross-complementing group 3

The susceptibility to glioma is not well understood. It has been suggested that the X-ray cross complementing group 3 (XRCC3) gene influences the capacity to repair DNA damage, leading to increased glioma susceptibility. In this study, we evaluated the relationship between XRCC3 mutations and glioma risk. Genotypes were assessed in 389 Chinese glioma patients and 358 healthy controls. ... more

J.Y. Huang; J.F. Yang; Q. Qu; J. Qu; F. Liu; F.E. Liu; T. Xiong; S.H. Lu
Betamethasone; Differentiation; ERK; Extracellular signal-regulated protein kinase; Glioma

We studied the differentiation-inducing effect of beta­methasone on human glioma cell line U251 cultured in vitro, and the underlying mechanism. U251 cells were divided into two groups: con­trol group cells, cultured in Dulbecco’s Modified Eagle’s medium con­taining 10% fetal bovine serum; and medication group cells, treated with 15 μM betamethasone. Morphological cell changes were ... more

T. Jin; Y.X. Wang; K. Fan; D.B. Tao; X. Dong; J.S. Shen
CXCL12 G801A polymorphism; Glioma; Tumor susceptibility

Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential ... more

S.F. Chang; S.L. Li; B. Yang; K.M. Yao; R.H. Miao; G.F. Liang; K.M. Zhang
ERCC2; Glioma; Meta-analysis; rs13181

Several studies have focused on the association between the ERCC2 rs13181 polymorphism and glioma risk, but the results were inconclusive. We aimed to conduct a meta-analysis to investigate the role of ERCC2 rs13181 on the risk of glioma. We searched and collated the relevant studies in both Chinese and English through the PubMed, Web of Science, Cochrane Library, and ... more

T.L. Jia; H.J. Wu; H.B. Wang; W.B. Ma; B. Xing
CCDC26; Glioma; Meta-analysis; Polymorphism; rs4295627

The association between the CCDC26 rs4295627 single nucleotide polymorphism (SNP) and the glioma risk has been studied previously, but these studies have yielded conflicting results. The aim of the present study is to analyze this association more vigorously, by means of a meta-analysis. A comprehensive literature search was performed in databases PubMed and EMBASE. Six articles ... more

H.W. Lu; M. Huang; J.H. Wang; X.L. Sun; Y.Q. Ke
DNA methylation; Glioma; Immunohistochemistry; SEMA3B

The aim of the current study was to explore mechanisms of SEMA3B gene expression and its clinical significance in glioma, and provide a theoretical foundation for investigating individualized treatment in glioma. Paraffin-embedded tissues from 43 patients with a confirmed clinical diagnosis of glioma following neurosurgery at the First Affiliated Hospital of Zhengzhou University from ... more

C.H. Pang; W. Du; J. Long; L.J. Song; C.H. Pang; W. Du; J. Long; L.J. Song; C.H. Pang; W. Du; J. Long; L.J. Song
Diagnosis; Meta-analysis; MicroRNAs; Thyroid cancer

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive ... more

G.J. Zhou; M. Xiao; L.N. Zhao; J.G. Tang; L. Zhang
Head and neck cancer; Meta-analysis; MicroRNAs; Screening

Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search for relevant studies up to August ... more

M. Zhang; L.J. Zhao; W.Q. Liang; Z.P. Mao
Acute lymphoblastic leukemia; MicroRNAs; Microvesicles; Zinc finger protein genes

Microvesicles (MVs) are submicrometric membrane fragments that can “engulf” cytoplasmic contents such as microRNAs (miRNAs) from their cellular origin. The study of miRNAs carried within MVs might provide insights into the roles that miRNAs play in the underlying pathophysiologic processes of acute lymphoblastic leu­kemia (ALL). We identified numerous dysregulated MV miRNAs in patients ... more

L. Lu; X.M. Chen; H.M. Tao; W. Xiong; S.H. Jie; H.Y. Li
Differentially expressed genes; MicroRNAs; RNA sequencing; Thyroid carcinoma; Transcription factors

In this study, we examined the molecular mechanism of thyroid carcinoma (THCA) using bioinformatics. RNA-sequencing data of THCA (N = 498) and normal thyroid tissue (N = 59) were downloaded from The Cancer Genome Atlas. Next, gene expression levels were calculated using the TCC package and differentially expressed genes (DEGs) were identified using the edgeR package. A co-expression ... more

J.C. Lu; Y.P. Zhang; J.C. Lu; Y.P. Zhang