Research Article

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09/27/2017
Acyclic Monoterpenes; DNA damage; Hep G2 Cells; Humans; Monocytes; Terpenes

Geraniol is an acyclic monoterpene alcohol present in the essential oil of many aromatic plants and is one of the most frequently used molecules by the flavor and fragrance industries. The literature also reports its therapeutic potential, highlighting itself especially as a likely molecule for the development of drugs against cancer. In view of these considerations, this study was designed to ... more

T.B. Queiroz; G.F. Santos; S.C. Ventura; C.A. Hiruma-Lima; I.O.M. Gaivão; E.L. Maistro
09/27/2017
Acute coronary syndrome; Aged; Case-control studies; Female; Genotype; Heterozygote; Humans; male; Mexico; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Single Nucleotide

Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polymorphisms to determine the association of rs4340 polymorphisms of the ... more

A. Valdez-Haro; Y. Valle; E. Valdes-Alvarado; F. Casillas-Muñoz; J.F. Muñoz-Valle; G.L. Reynoso-Villalpando; H.E. Flores-Salinas; J.R. Padilla-Gutiérrez
09/27/2017
Down syndrome; Heart Defects, Congenital; Humans; Infant; Karyotype; Klinefelter syndrome; male

Double aneuploidy is considered a rare phenomenon. Herein, we describe a case of double aneuploidy 48,XXY,+21 in a neonate with congenital heart defects. The 28-day-old neonate male (23-year-old mother and 24-year-old father) was admitted to a neonatal intensive care unit owing to congenital heart disease. Echocardiography showed a complete atrioventricular septal defect with Rastelli type B ... more

M.A. Rodrigues; L.F. Morgade; L.F.A. Dias; R.V. Moreira; P.D. Maia; A.F.H. Sales; P.D. Ribeiro
09/27/2017
Ecuador; Gene frequency; Humans; Microsatellite Repeats; Polymorphism, Genetic; Population

One hundred and eighty-two samples of unrelated people who requested the paternity test at the Molecular Biology and Genetics Laboratory of the Catholic University of Cuenca-Ecuador in the province of Azuay were studied, except for the D1S1656 (180 samples) and SE33 (89 samples) markers. The STRs D22S1045, D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01, FGA, D1S1656, ... more

P.P. Orellana; C.F. Andrade; C.L. Arciniegas; G.C. Iannacone
3/16/2017
Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Leukocytes; male; Mangifera; Medicine, Traditional; Mice; Oils, Volatile; Peroxidase; Plant Leaves; Plant Oils; Rats

Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. Twenty-three volatile compounds were identified via gas chromatography-mass ... more

R.M. Oliveira; T.S. Dutra; E. Simionatto; N. Ré; C.A.L. Kassuya; C.A.L. Cardoso
4/13/2017
Animals; Animals, Inbred Strains; Ear; Extracellular Matrix Proteins; Gene expression profiling; Genome-wide association study; Intercellular Signaling Peptides and Proteins; Methionine Sulfoxide Reductases; Quantitative trait loci; RNA, Messenger; Swine

Porcine ear size is an important characteristic for distinguishing among pig breeds. In a previous genome-wide association study of porcine ear size, LEM domain-containing 3 (LEMD3), methionine sulfoxide reductase B3 (MSRB3), high mobility group AT-hook 2 (HMGA2), and Wnt inhibitory factor 1 (WIF1) were implicated as important candidate genes for ear size. This study investigated the ... more

L.C. Zhang; J. Liang; L. Pu; Y.B. Zhang; L.G. Wang; X. Liu; H. Yan; L.X. Wang
05/25/2017
Animals; Apoptosis Regulatory Proteins; meat; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; RNA, Messenger; Swine

Cell death-inducing DFF45-like effector (CIDE) B is a member of the CIDE family of apoptosis-inducing factors. In the present study, we detected a single nucleotide polymorphism (SNP), c.414G>A, which corresponds to the synonymous SNP 414Arg, in CIDE-B in the Berkshire pigs. We also analyzed the relationships between the CIDE-B SNP and various meat quality traits. The SNP was significantly ... more

G.E. Yu; S. Kwon; J.H. Hwang; S.M. An; D.H. Park; D.G. Kang; T.W. Kim; I.S. Kim; H.C. Park; J. Ha; C.W. Kim
09/27/2017
Animals; Gene Expression Regulation, Developmental; Rabbits; Retina; RNA, Messenger; Rod Opsins; Thy-1 Antigens

Melanopsin is the photopigment of intrinsically photosensitive retinal ganglion cells that mediate non-visual responses to light. The aim of this study was to describe and analyze melanopsin gene expression in the rabbit retina at different ages and compare its expression with the prototypic gene of retinal ganglion cells (Thy-1 gene). Expression levels of OPN4, Thy-1, and GADPH genes were ... more

M.M. Lira-Carrera; B.E. Gutiérrez-Amavizca; L.J. Álvarez-Araujo; M. Aguirre-Ramírez; J.A. Pérez-León
09/27/2017
Arachis; Genotype; Plant Leaves; Plant Proteins; Resveratrol; RNA, Messenger; Stilbenes; Tetraploidy; Transcriptional activation; Ultraviolet Rays

Resveratrol is an antioxidant that is a promising antitumoral, cardioprotective and neuroprotective agent. It has been found in a restricted number of plants including peanut (Arachis hypogaea L.) and its wild relatives. The objective of this study was to understand the relationship between resveratrol content and the expression of putative resveratrol synthase genes in four Arachis genotypes ... more

P.A.S.V. Carvalho; A.C. Brasileiro; S. Leal-Bertioli; D.J. Bertioli; J.P. Silva; T.S. Agostini-Costa; M.A. Gimenes

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