Research Article

Related GMR Articles

3/15/2017
Adult; Asian People; CARD Signaling Adaptor Proteins; Case-control studies; China; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Humans; male; Middle Aged; Polymorphism, Single Nucleotide; Psoriasis; Risk; Sequence Analysis, DNA

Previously, we determined that the CARD11 rs4722404 single nucleotide polymorphism (SNP) increases risk of early-onset psoriasis vulgaris (PsV). Moreover, the CARD14 gene polymorphism c.C2458T (p.Arg820Trp) is associated with clinical features of this disease. CARMA1/CARD11, CARMA2/CARD14, and CARMA3/CARD10 are conserved across many species and constitute a family of proteins, all of the ... more

G. Shi; M.F. Zhang; P.Y. Liao; T.T. Wang; S.J. Li; Y.M. Fan; K.J. Zhu
03/31/2006
Algorithm; Base-calling analysis; Chromatogram; HIV; Sequence alignment; Single nucleotide polymorphism

A great effort has been made to identify and map a large set of single nucleotide polymorphisms. The goal is to determine human DNA variants that contribute most significantly to population variation in each trait. Different algorithms and software packages, such as PolyBayes and PolyPhred, have been developed to address this problem. We present strategies to detect single nucleotide ... more

M. Galves; J.Augusto Am Quitzau; Z. Dias
09/30/2005
Dynamic programming; Hardware; Reconfigurable architectures; Sequence alignment

Reconfigurable systolic arrays can be adapted to efficiently resolve a wide spectrum of computational problems; parallelism is naturally explored in systolic arrays and reconfigurability allows for redefinition of the interconnections and operations even during run time (dynamically). We present a reconfigurable systolic architecture that can be applied for the efficient treatment of ... more

R.P. Jacobi; M. Ayala-Rincón; L.G.A. Carvalho; C.H. Llanos; R.W. Hartenstein
09/30/2005
Computational biology; Distributed systems; Interpro; Tools

Interpro is a widely used tool for protein annotation in genome sequencing projects, demanding a large amount of computation and representing a huge time-consuming step. We present a strategy to execute programs using databases Pfam, PROSITE and ProDom of Interpro in a distributed environment using a Java-based messaging system. We developed a two-layer scheduling architecture of the ... more

Ede O. Ribeiro; G.G. Zerlotini; I.R.M. Lopes; V.B.R. Ribeiro; A.C.M. Melo; M.Emilia M.T. Walter; M.Emilia M.T. Walter; M.Mota Costa; B.I.O.F.O.C.O. Network
11/14/2012
Alpha 1-antitrypsin; Alpha-fetoprotein; Proteins; Transferring; Western blotting; Yolk sac

The yolk sac is an embryonic membrane that is essential for the embryo’s initial survival in many mammals. It also plays an important role in the production of proteins necessary for development. We studied proteins of the yolk sac in bovine embryos at up to 40 days of gestation. We examined the yolk sac of 17 bovine embryos at different gestational periods, measuring α-fetoprotein, α-1- ... more

F.S. Matsumoto; V.C. Oliveira; C.A.F. Mançanares; C.E. Ambrósio; M.A. Miglino
06/11/2015
Apoptosis; Fetal membranes; Metabolic pathways; Metabolites; Proteins

In several species, placentation involves the presence of two different membranes responsible for maternal-fetal exchanges: the yolk sac and the chorioallantoic placenta. The yolk sac plays important roles in embryonic survival, mainly during the early stages of gestation. In bovine, it is a transitional membrane that is present until day 50-70 of pregnancy. Herein, we evaluated the ... more

A.C. Galdos-Riveros; P.O. Favaron; S.E.A.L. Will; M.A. Miglino; D.A. Maria
11/30/2019
Mass spectrometry; Photosynthesis; Proteins; Two-dimensional electrophoresis; Vigna unguiculata

Cowpea (Vigna unguiculata) is of great importance for human consumption due to its high nutritional value. The crop is grown in tropical and subtropical regions of the world; however, grain productivity is severely affected by water restriction imposed by long periods of drought in semiarid regions. We compared two contrasting cowpea genotypes for drought ... more

E.N. Lima; M.Ldos S. Silva; C.E.B. de Abreu; R.O. Mesquita; M.D.P. Lobo; A.Cde O. Monteiro-Moreira; E. Gomes-Filho; C.H.Cde M. Bertini
05/09/2012
Amino acid sequence; Cysteine pattern; LiTat 1.5; Trypanosoma brucei gambiense; VSG

At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement of the native VSGs by recombinant proteins or synthetic peptides, the sequence of VSG LiTat 1.5 was derived from cDNA and ... more

L. Van Nieuwenhove; S. Rogé; V. Lejon; Y. Guisez; P. Büscher
11/21/2016
Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Uterine cervical neoplasms

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl blue tetrazolium bromide assay, caspase-3 activity, and ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
12/02/2016
Asian People; Child; Chromosome Deletion; Chromosomes, Human, Pair 2; Fingers; Heart Defects, Congenital; Hedgehog Proteins; Humans; Karyotype; male; Syndactyly; Waardenburg Syndrome

Reports of terminal and interstitial deletions of the long arm of chromosome 2 are rare in the literature. Here, we present a case report concerning a Chinese boy with a 47,XYY karyotype and a de novo deletion comprising approximately 5 Mb between 2q35 and q36.1, along with syndactyly, type III Waardenburg syndrome, and congenital heart disease. High-resolution chromosome analysis to detect ... more

D. Wang; G.F. Ren; H.Z. Zhang; C.Y. Yi; Z.J. Peng

Pages