Research Article

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Atherosclerosis; Female; Genetic association studies; Genetic predisposition to disease; Genotype; Glutathione transferase; Humans; male; Middle Aged; Polymorphism, Genetic; Risk factors; Smoking

Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include hypertension, smoking, obesity, high LDL and low HDL cholesterol ... more

D.A. Rodrigues; J.V.M. Martins; K.S.F.E. Silva; I.R. Costa; M.H. Lagares; F.L. Campedelli; A.M. Barbosa; M.P. de Morais; K.K.V.O. Moura
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Adult; Aged; Down-regulation; Factor VIII; Female; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Humans; Lymphatic metastasis; male; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Nuclear Proteins; Stomach neoplasms; Vascular Endothelial Growth Factor A

Association of signal-induced proliferation-associated 1 (SIPA) gene and protein expression with gastric cancer development was examined. SIPA1 mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and western blot, respectively, in 40 gastric tumor and tumor-adjacent normal tissues. SIPA1, VEGF-A, and FVIII levels in 60 gastric tumor and 40 tumor-adjacent ... more

J.Y. Li; J.B. Wang; C.B. Liu; D.L. Ma; J.H. Ma
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Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Female; Humans; Interferon-gamma; Interleukin-10; Interleukin-4; male; Prognosis; Severity of Illness Index; Spondylitis, Ankylosing; Th1 Cells; Th2 cells; Tumor necrosis factor-alpha; Young Adult

Ankylosing spondylitis (AS), a progressive disease of the spine, manifests as peripheral arthritis with tendon and ligament inflammation that restricts activity. AS is a rheumatoid autoimmune disease although the rheumatoid factor is absent in patients with AS. It is characterized by inflammatory changes such as elevated levels of serum inflammatory factors. The roles of Th1 and Th2 cytokines ... more

J.T. Wen; D.H. Zhang; P.F. Fang; M.H. Li; R.J. Wang; S.H. Li
3/16/2017
Animals; Aquaculture; Cichlids; Ethanol; Fish Proteins; Gene Expression Regulation; male; Muscle, Skeletal; Myostatin; Organ Size; Plant Extracts; Propolis

Propolis can be used as growth enhancer due to its antimicrobial, antioxidant, and immune-stimulant properties, but its effects on morphometry and muscle gene expression are largely unknown. The present study evaluates the influence of propolis on muscle morphometry and myostatin gene expression in Nile tilapia (Oreochromis niloticus) bred in net cages. Reversed males (GIFT strain) with an ... more

E.L. Buck; I.Y. Mizubuti; A.A. Alfieri; R.A.A. Otonel; L.Y. Buck; F.P. Souza; O.P. Prado-Calixto; A.R. Poveda-Parra; A. Filho; N.M. Lopera-Barrero
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Female; Genetic predisposition to disease; Humans; male; Odds Ratio; Platelet Membrane Glycoproteins; Polymorphism, Single Nucleotide; Stroke

Ischemic stroke can lead to loss of neurologic functions. It occurs due to obstruction in blood supply to the brain. It has been proposed that C807T(C/T) polymorphism within the platelet glycoprotein gene may be associated with density and function of glycoprotein Ia/IIa receptors and contributes to the pathogenesis of thrombotic disease. We assessed the association between C807T(C/T) and risk ... more

C. Luo; L.H. Fan; H. Zhang; J. Zhao; L. Li; L. Zhang; H.X. Zhang; M.M. Ma
3/16/2017
1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Colorectal neoplasms; DNA damage; Ethanol; male; Mice; Micronucleus tests; Plant Extracts; Xenograft Model Antitumor Assays

The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has ... more

S.M.A. Limeiras; B.C. Oliveira; L.R. Pessatto; J.R. Pesarini; C.A.L. Kassuya; A.C.D. Monreal; W.B. Cantero; R. Antoniolli-Silva; A.C.M.B. Antoniolli-Silva; M.E.A. Stefanello; R.J. Oliveira
3/30/2017
Adult; Aged; Aged, 80 and over; Alleles; Asian People; Case-control studies; Female; Genetic association studies; Genetic predisposition to disease; Humans; Interleukin-17; Laryngeal Neoplasms; male; Middle Aged; Polymorphism, Single Nucleotide; Risk factors; Smoking

IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer in the Chinese population. A case ... more

F.Z. Si; Y.Q. Feng; M. Han
3/30/2017
Adult; Case-control studies; Chronic Disease; Female; Humans; Macrophages; male; Middle Aged; Periapical Diseases; Periapical Granuloma; Radicular Cyst; Transforming Growth Factor beta1

The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to classified standards, namely, healthy control (N = 25), periapical ... more

Z.Z. Liang; J. Li; S.G. Huang
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Animals; Apoptosis; Blood glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Ginsenosides; Glucose; Insulin; JNK Mitogen-Activated Protein Kinases; Lipids; Liver; Liver Diseases; male; Random Allocation; Rats; Rats, Sprague-Dawley

Type 2 diabetes mellitus (T2-DM) is a chronic metabolic disorder characterized by high blood glucose levels. T2-DM patients suffer from many complications, such as diabetic fatty liver and diabetic nephropathy. The liver, the pivotal organ involved in both glucose and lipid metabolism, is primarily damaged in T2-DM patients, especially in those with high levels of blood lipid. In this study, ... more

W. Tian; L. Chen; L. Zhang; B. Wang; X.B. Li; K.R. Fan; C.H. Ai; X. Xia; S.D. Li; Y. Li
3/30/2017
Adult; Aged; Antineoplastic Agents; Caspase 3; Caspase Inhibitors; Disease-free survival; Everolimus; Female; Humans; Immunohistochemistry; Ki-67 Antigen; male; Middle Aged; Neuroendocrine Tumors; Protein Kinase Inhibitors

Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki-67 and caspase-3 in NET. ... more

H.Y. Zhang; X.B. Cheng; Y. Li; L.D. Jin; H.P. Yin

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