Research Article

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Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang
Animals; Bone morphogenetic protein 2; Genetic Therapy; Humans; Mandible; Osteogenesis, Distraction; Rabbits; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A

Transforming growth factor-β1 (TGF-β1) is a member of the TGF-β superfamily, and plays an important role in promoting various stages of intramembranous and endochondral bone formation. It is one of the major growth factors that influence new bone formation in the distraction gap during distraction osteogenesis (DO). The major problem of DO is the time required for the treatment. Reports show ... more

M.K. Xie; C.B. Hu; B. Zhou; G.P. Wu
Cells, Cultured; DNA damage; Euterpe; Fruit; Hep G2 Cells; Humans; Lymphocytes; Plant Oils

Euterpe oleracea Mart., popularly known as "açaí", is a tropical fruit from the Amazon region where it has considerable economic importance. Açaí has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is a lack of data regarding the safety of using this fruit oil exclusively. Therefore, we evaluated the in vitro cytotoxic, genotoxic, and ... more

E.S. Marques; M.S.F. Tsuboy; J.C.T. Carvalho; P.C.P. Rosa; F.F. Perazzo; I.O.M. Gaivão; E.L. Maistro
Case-control studies; Chronic obstructive pulmonary disease; Genetic predisposition to disease; Matrix metalloproteinases; Single nucleotide polymorphism

There are many candidate genes for chronic obstructive pulmonary disease (COPD). One such candidate is the group of genes that code for matrix metalloproteinases (MMPs), which play an essential role in tissue remodeling and repair associated with COPD. We tested the hypothesis that polymorphic variation in MMP genes influences the risk of developing COPD by examining functional ... more

H. Schirmer; B. da Silva; P.J.Z. Teixeira; J.S. Moreira; A.L.S. Moreira; D. Simon
Case-control studies; Dopamine; Frequency; Genetic polymorphism; Nursing; Receptors; Schizophrenia

Schizophrenia is considered one of the most severe and complex mental disorders; it affects both the quality of life of the patient and his family. The dopamine hypothesis is the main concept concerning antipsychotic activity. Patients with treatment-refractory schizophrenia have a lower capacity for dopamine synthesis than those with a good response to first- ... more

F.D.D. Nunes; J.A.F. Pinto; P.H.B. Freitas; L.L. Santos; R.M. Machado
Biomarkers; Non-tumoral breast tissue; Proteomics

Breast cancer is a complex and heterogeneous disease. In spite of the advances made in recent decades, a better understanding of the intrinsic mechanisms of this disease is crucial. The development of new biomarkers is absolutely necessary to improve diagnosis and prognosis. Research using the proteomic approach has generated interesting results; however, the complexity of the mammary ... more

G.G. Costa; R. Kaviski; L.E.R. Souza; C.A. Urban; R.S. Lima; I.J. Cavalli; E.M.S.F. Ribeiro
Biomarkers; Curative effect; Esophageal cancer; National difference

This study aimed to explore some useful biomarkers to focus on the diagnosis and therapy response judgment in esophageal squamous cell carcinoma in Xinjiang. We used enzyme-linked immunosorbent method and immunohistochemistry to detect the expression of VEGF, EGFR, ES, HER-2, and NF-κBp in the serum and tissue with esophageal squamous cell carcinoma, and to analyze the relationship ... more

L. Zhang; J. Sun; J.Q. Zhang; M. Yang; G. Bai; X.L. Ma
Bioinformatics; Biomarkers; Cancer; Immunohistochemistry

Identification of cancer-associated and tissue-specific proteins is important for research on carcinogenesis mechanisms and biomarker discovery. Here we performed a new strategy to identify candidate cancer proteins by mining immunohistochemistry protein profiles. Proteins with quantitative values from 14 normal tissues and their corresponding cancer tissues were compared and analyzed ... more

X.X. Liu; F.J. Liu
Biomarkers; Colorectal cancer; DKK2 gene; DNA methylation; Epigenetics
Purpose: Epigenetic changes can be detected in precancerous lesions, suggesting that may be involved in the early stages of carcinogenesis. The methylation of specifics genes has been correlated with the outcome of many different types of cancers. This study compared the levels of DNA methylation between normal and tumor tissues from patients with colorectal ... more
T.D. Silva; A.V. Felipe; V.M. Vidigal; S.S. Saad; N.M. Forones
Biomarkers; Conventional antibodies; Nanobodies; Production Techniques; Therapeutic applications

Nanobodies (Nbs) are mini antibodies 10 times smaller than conventional antibodies. They constitute a new class of antibodies devoid of light chains. Their paratope consists of a single variable domain "VHH" (heavy chain variable domain) formed by a single peptide chain. Nevertheless, Nbs maintain the same repertoire of diversity and affinity characteristics as ... more

H. Boulenouar; Y. .Amar; N. Bouchoutrouch; M.E.A. Faouzi; Y. Cherrah; H. Sefrioui