Research Article

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1/23/2017
Animals; Biomarkers; Cell line; G-Protein-Coupled Receptor Kinase 2; Humans; Mechanical Phenomena; Mice; Osteoblasts; Phosphorylation; Receptors, Purinergic P2Y2; Signal transduction

Bone desensitization after mechanical loading is essential for bone to adapt to its mechanical environment. However, the desensitization mechanism is unknown. Previous studies suggest that G protein-coupled receptors (GPCRs), including P2Y and parathyroid hormone receptors, play important roles in osteoblast mechanobiology. Thus, for the present research, we examined the role of G protein- ... more

Y. Xing; Y. Gu; X. Shan; L. Wang; J. You
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Animals; Antimutagenic Agents; Antioxidants; Chromosome aberrations; Cyclophosphamide; Fruit; male; Malpighiaceae; Models, Animal; Plant Extracts; Rats; Rats, Wistar

Barbados cherry (BC) (Malpighia glabra Linnaeus) is a functional fruit that is consumed to prevent disease. It is used as an adjuvant in the treatment of several diseases, and acts as an antianemic, an appetite stimulant, a wound healer, an anti-inflammatory, a mineralizer, an antifungal, and an antioxidant agent. Several chemotherapeutic agents, such as cyclophosphamide, may result in ... more

E. Düsman; I.V. Almeida; L.T.D. Tonin; V.E.P. Vicentini
3/22/2017
1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Colorectal neoplasms; Dietary Supplements; DNA damage; Intestinal Mucosa; male; Mice; Probiotics; Yogurt

Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a ... more

S.M.A. Limeiras; F.M. Ogo; L.A.L. Genez; C.M. Carreira; E.J.T. Oliveira; L.R. Pessatto; S.C. Neves; J.R. Pesarini; L.C. Schweich; R.A. Silva; W.B. Cantero; A.C.M.B. Antoniolli-Silva; R.J. Oliveira
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Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Leukocytes; male; Mangifera; Medicine, Traditional; Mice; Oils, Volatile; Peroxidase; Plant Leaves; Plant Oils; Rats

Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. Twenty-three volatile compounds were identified via gas chromatography-mass ... more

R.M. Oliveira; T.S. Dutra; E. Simionatto; N. Ré; C.A.L. Kassuya; C.A.L. Cardoso
3/16/2017
Animals; Aquaculture; Cichlids; Ethanol; Fish Proteins; Gene Expression Regulation; male; Muscle, Skeletal; Myostatin; Organ Size; Plant Extracts; Propolis

Propolis can be used as growth enhancer due to its antimicrobial, antioxidant, and immune-stimulant properties, but its effects on morphometry and muscle gene expression are largely unknown. The present study evaluates the influence of propolis on muscle morphometry and myostatin gene expression in Nile tilapia (Oreochromis niloticus) bred in net cages. Reversed males (GIFT strain) with an ... more

E.L. Buck; I.Y. Mizubuti; A.A. Alfieri; R.A.A. Otonel; L.Y. Buck; F.P. Souza; O.P. Prado-Calixto; A.R. Poveda-Parra; A. Filho; N.M. Lopera-Barrero
3/16/2017
1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Antineoplastic Agents, Phytogenic; Asteraceae; Colorectal neoplasms; DNA damage; Ethanol; male; Mice; Micronucleus tests; Plant Extracts; Xenograft Model Antitumor Assays

The objective of this study was to evaluate the effect of Moquiniastrum polymorphum ssp floccosum ethanolic extract (MPEE) on 1,2 dimethylhydrazine (DMH)-induced colorectal carcinogenesis in mice. Forty-two male Swiss mice (Mus musculus) were subdivided into six groups (N = 7/group): negative control, DMH, MPEE, pre-treatment, simultaneous, and post-treatment. Results showed that MPEE has ... more

S.M.A. Limeiras; B.C. Oliveira; L.R. Pessatto; J.R. Pesarini; C.A.L. Kassuya; A.C.D. Monreal; W.B. Cantero; R. Antoniolli-Silva; A.C.M.B. Antoniolli-Silva; M.E.A. Stefanello; R.J. Oliveira
08/17/2017
alpha-Amylases; Animal Husbandry; Animals; Chickens; Diet; Dietary Supplements; Digestion; Energy metabolism; male

This study aimed to evaluate the supplementation levels of an exogenous alpha-amylase in broilers diets and compare two indicators in determining the diets energy. The experiment was divided into two parallel evaluations, being one of performance and the other of metabolism. In performance assay, 1,700 one-day-old Cobb-500 male chicks were used. The animals were distributed in 50 experimental ... more

H.B. Oliveira; M.I.A. Silva; F.R. Mesquita
05/10/2017
Adipose tissue; Animals; Antioxidants; Body weight; Camellia sinensis; Chromosomal Proteins, Non-Histone; Chronotherapy; Circadian rhythm; Diet; Eating; Female; Homeostasis; Lipid metabolism; Liver; Liver X Receptors; Mice; Ovary; Oxidation-Reduction; Plant Extracts; Tea

Biological rhythms can be defined as changes in physiological or behavioral variables that repeat at certain time intervals. Rhythms that last approximately 24 h are referred to as circadian rhythms. Modern lifestyles have drastically affected human habits, as well as the population's eating habits. These changes have generated an epidemic of metabolic syndromes, such as obesity and diabetes. ... more

R.P. Amorim; I.P. Daher; F.P.D. Arcangelo; M.F. Bellini; W.A. Orcini; G.R. Sarria; R.L. Peruquetti
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Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Uterine cervical neoplasms

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl blue tetrazolium bromide assay, caspase-3 activity, and ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
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Animals; Apoptosis; Cells, Cultured; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gonadotropins, Equine; Horses; In Vitro Oocyte Maturation Techniques; Oocytes; Receptors, FSH; Receptors, LH; Receptors, LHRH; Sheep

We assessed the effects of equine chorionic gonadotropin (eCG) on oocyte in vitro maturation (IVM), apoptosis, and follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), and gonadotropin-releasing hormone receptor (GnRHR) expression and mRNA levels. Cumulus-oocyte complexes (COCs) were recovered from sheep ovaries and pooled in groups, before being cultured in IVM ... more

S.C. Wei; Z.D. Gong; H.W. Zhao; H.Q. Liang; L.J. Lai; Y.Y. Deng

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