Research Article

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08/31/2017
Alveolar Epithelial Cells; Animals; CD11b Antigen; Female; male; Mice; Mice, Inbred C57BL; Pulmonary Surfactant-Associated Proteins; Respiratory Insufficiency

As a β2 integrin family member, Mac-1 plays an important role in the inflammatory response. Inflammation and lung injury are closely associated, but the involvement of Mac-1 in the occurrence and development of such pathologies remains poorly understood. We aimed to investigate the relationship between Mac-1 deficiency and respiratory failure in Mac-1 knockout {Mac-1} mice, using C57BL/6J mice ... more

J. Wang; Y.B. Ci; C.L. Liu; H.M. Sun
09/27/2017
Amaranthaceae; Animals; Antimutagenic Agents; Bone marrow cells; Chromosome aberrations; Cyclophosphamide; Female; Ginkgo biloba; male; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar

Complementary and alternative therapies, including the use of medicinal plants, have become almost standard among the world's population. Pfaffia glomerata (PG), popularly known as Brazilian ginseng, is widely used as a restorer of vital functions, increasing mental balance, and is used for the treatment of diabetes and rheumatism. Ginkgo biloba (GB) is one of the oldest known gymnosperms, ... more

I.V. Almeida; E. Düsman; G.I. Mattge; F. Toledo; A.F. Reusing; V.E.P. Vicentini
12/23/2016
Alleles; Case-control studies; Female; Genetic predisposition to disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polycystic ovary syndrome; Polymorphism, Single Nucleotide

Polycystic ovary syndrome is one of the most frequently encountered endocrine malfunctions. Methylenetetrahydrofolate reductase (MTHFR) plays a vital role in folate metabolism, DNA methylation, and RNA synthesis. We carried out a study to investigate the association between MTHFR C677T and A1298C genetic variations and the risk of polycystic ovary syndrome in a Chinese population. We recruited ... more

J.B. Wu; J.F. Zhai; J. Yang
1/23/2017
Alleles; Case-control studies; Female; Genetic association studies; Genetic predisposition to disease; Genotype; Humans; Odds Ratio; Polymorphism, Genetic; Tumor Protein p73; Uterine cervical neoplasms

The aim of this study was to investigate the tumor protein p73 (TP73) G4C14-A4T14 polymorphism and to perform a meta-analysis to assess TP73 expression in cervical cancer and precancerous tissue. Articles containing data regarding TP73 status in cervical cancer patients and healthy controls were retrieved from PubMed, EMBASE, Cochrane, Chinese Biomedical Literature, and China National ... more

H. Feng; L. Sui; M. Du; Q. Wang
12/02/2016
Animals; Brazil; Breeding; Cattle; Gene frequency; Genetic markers; Leptin; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Red Meat; Sequence Analysis, DNA

Brazil is the world's largest producer of beef cattle; however, the quality of its herds needs to be improved. The use of molecular markers as auxiliary tools in selecting animals for reproduction with high pattern for beef production would significantly improve the quality of the final beef product in Brazil. The leptin gene has been demonstrated to be an excellent candidate gene for bovine ... more

R.C. Guimarães; J.S.N. Azevedo; S.C. Corrêa; J.E.G. Campelo; E.M. Barbosa; E.C. Gonçalves; S. Filho
05/31/2017
Bromeliaceae; Gene Amplification; Gene frequency; Heterozygote; Inbreeding; Microsatellite Repeats; Polymorphism, Genetic

The Alcantarea patriae is a Bromeliaceae endemic to the inselbergs of the Atlantic Forest. This taxon, described in the year of 2007 by Versieux & Wanderley, presents restricted and fragmented distribution outside conservation units. Studies to evaluate the genetic structure of its populations can contribute to the conservation and management strategies for the species. In this study, 31 ... more

A.G. Pereira; U.C.S. Bernardi; V.C. Manhães; R.S. Ferreira; F.D. Miranda
08/31/2017
Arecaceae; Evolution, Molecular; Gene flow; Gene frequency; Heterozygote; Linkage disequilibrium; Microsatellite Repeats; Polymorphism, Genetic

We assessed the level and distribution of genetic diversity in three species of the economically important palm genus Astrocaryum located in Pará State, in northern Brazil. Samples were collected in three municipalities for Astrocaryum aculeatum: Belterra, Santarém, and Terra Santa; and in two municipalities for both A. murumuru: Belém and Santo Antônio do Tauá and A. paramaca: Belém and ... more

N.P. Oliveira; M.S.P. Oliveira; L.C. Davide; S. Kalisz
12/04/2014
Acute lymphoblastic leukemia; Adolescent; Child; Myeloid anomalous expression; Platelet count; Prognosis

The aim of this study was to evaluate myeloid expression in acute lymphoblastic leukemia (ALL) in children and adolescents who had been referred to the Oncology Department in a hospital in the State of Maranhão based on demographic, laboratory, and clinical data. Myeloid expression was evaluated in 65 patients under 18 years of age who were diagnosed with morphological, cytochemical, and ... more

T.C. Lopes; K.N.S. Andrade; N.L. Camelo; V.P. Rodrigues; R.A.G. Oliveira
12/19/2016
China; Chromosomes, Plant; Cotton Fiber; Genotype; Gossypium; Plant breeding; Polymorphism, Genetic; Quantitative trait loci

Upland cotton (Gossypium hirsutum L.) is an important cash crop that provides renewable natural fiber worldwide. Currently limited genetic base leads to a decrease in upland cotton genetic diversity. Multi-parent advance generation inter-cross (MAGIC) populations can be used to evaluate complex agronomic traits in crops. In this study, we developed an upland cotton MAGIC population. A total of ... more

D.G. Li; Z.X. Li; J.S. Hu; Z.X. Lin; X.F. Li
3/08/2017
Brassica; China; Chromosome Mapping; Chromosomes, Plant; DNA fingerprinting; DNA, Plant; Genetic markers; Genotype; Microsatellite Repeats; Plant breeding; Polymorphism, Genetic

Chinese cabbage is an important cruciferous vegetable in China. The differences in the morphology and other characteristics of the different varieties of Chinese cabbage are generally caused by their different genes. Using the simple sequence repeat (SSR) DNA molecular markers is an effective way to identify different genotypes. The identification of a genetic relationship is a key point in ... more

X.X. Zhang; X.B. Tang; Y. Liu; Y.W. Zhang

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