Research Article

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09/09/2015
Apoptosis; Liver cirrhosis; Macrophage; Renal injury; Xiayuxue decoction

Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting renal macrophage apoptosis. The rats were treated with BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day ... more

C. Liu; J. Cai; Z. Cheng; X. Dai; L. Tao; J. Zhang; D. Xue
09/08/2015
A431 cells; Apoptosis; Bcl-2; Berberine; Proliferation; Squamous cell carcinoma

Berberine (BBR) is a natural alkaloid with significant anti-tumor activity against many types of cancer cells. In this study, we investigated the molecular mechanisms employed by BBR to repress the proliferation and growth of skin squamous cell carcinoma A431 cells. Berberine was reported to inhibit the proliferation of A431 cells in a dose- and time-dependent manner and was observed to induce ... more

D.X. Li; J. Zhang; Y. Zhang; P.W. Zhao; L.M. Yang
08/10/2015
Acute cerebral infarction; Apoptosis; Baculovirus P35 protein

We explored the effect of baculovirus P35 protein on apoptosis in the brain tissue of rats with acute cerebral infarction (ACI). A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model, and treatment groups. Baculovirus P35 protein was injected into the intracranial arteries of the treatment group rats. The rats in the model group were ... more

J.F. Ji; X.H. Ma
08/14/2015
5-aminolevulinic acid; Apoptosis; Sonodynamic therapy; UMR-106 cells

We investigated the killing effect of low-intensity ultrasound combined with 5-aminolevulinic acid (5-ALA) on the rat osteosarcoma cell line UMR-106. Logarithmic-phase UMR-106 cells were divided into a control group, ultrasound group and 5-ALA group. The cell apoptotic rate, production of reactive oxygen species, and the change in mitochondrial membrane potential were analyzed by flow ... more

Y.N. Li; Q. Zhou; B. Yang; Z. Hu; J.H. Wang; Q.S. Li; W.W. Cao
07/27/2015
Apoptosis; cFLIP; Corpus albicans; Corpus luteum; Porcine

We determined expression and localization of the anti-apoptotic cellular FLICE inhibitory protein (cFLIP) in the porcine corpora lutea (CL) and corpus albicans (CA) during estrous and preg­nancy. The CL and CA were collected at different stages of estrous to determine cFLIP immunolocalization, and mRNA and protein ex­pression. The mRNA expression of the short cFLIP isoform (cFLIPS ... more

H.Z. Jin; W.S. Shi; Y. Tian; Y. Liu; Y. Jin; N. Manabe
07/06/2015
Apoptosis; C-33A; Caspase; Cervical cancer; FoxO1; TNF-α

Tumor necrosis factor-α (TNF-α) is an important pro-apoptotic cytokine, which performs a broad range of immune and inflammatory functions in several vital processes. TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer. In our study, we used the well- ... more

B. Zhang; L. Gui; L. Zhu; X. Zhao; Y. Yang; Q. Li
07/13/2015
Acute cerebral infarction; Apoptosis; Bcl-2

We aimed to investigate the influence of lentiviral-medi­ated Bcl-2 overexpression in cerebral tissues of rats with acute cerebral infarction. Forty-five rats were randomly divided into sham, model, and treatment groups. The sham and model groups were administered a control lentiviral vector via the intracranial arteries 10 days before surgery, while the treatment group received lentivirus ... more

H.R. Zhang; J.H. Peng; G.Y. Zhu; R.X. Xu
12/29/2015
Apoptosis; miR-126; Myocardial ischemia-reperfusion

Multiple studies have shown microRNAs to play an important role in disease occurrence and development. The role of miRNAs in ischemia-reperfusion injury, however, requires further investigation and the aim of this study was therefore to assess miR-126 expression in myocardial ischemia reperfusion and the effects of miR-126 on myocardial ischemia-reperfusion injury. An in vitro ... more

B. Li; Y. Tao; Q. Huang
12/22/2015
Apoptosis; Fas/FasL; Neurogenesis; Sevoflurane

Sevoflurane, the most widely used anesthetic in clinical practice, has been shown to induce apoptosis, inhibit neurogenesis, and cause learning and memory impairment in young mice. However, the underlying mechanism is still unknown. In this study, wild-type and the FAS- or FAS ligand (FASL)-knockout mice (age 7 days) were exposed to sevoflurane or pure oxygen. Western blotting was used to ... more

Q. Song; Y.L. Ma; J.Q. Song; Q. Chen; G.S. Xia; J.Y. Ma; F. Feng; X.J. Fei; Q.M. Wang
12/17/2015
Acute leukemia; Apoptosis; Children; Interleukin-24; Mononuclear cell

To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro. Four groups were assessed: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-leukemia, and healthy groups, 20 children in each group. ELISA was used to measure IL-24 serum level. The bone ... more

H.R. Cheng; B.Q. Wu; L. Chen; Z.X. Zhang; B. Li

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