Research Article

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03/16/2017
Female; Genetic predisposition to disease; Humans; male; Odds Ratio; Platelet Membrane Glycoproteins; Polymorphism, Single Nucleotide; Stroke

Ischemic stroke can lead to loss of neurologic functions. It occurs due to obstruction in blood supply to the brain. It has been proposed that C807T(C/T) polymorphism within the platelet glycoprotein gene may be associated with density and function of glycoprotein Ia/IIa receptors and contributes to the pathogenesis of thrombotic disease. We assessed the association between C807T(C/T) and risk ... more

C. Luo; L.H. Fan; H. Zhang; J. Zhao; L. Li; L. Zhang; H.X. Zhang; M.M. Ma
03/16/2017
Alendronate; Animals; Bone Density Conservation Agents; Bone morphogenetic protein 2; Cytokines; Disease Models, Animal; Dyskinesias; Female; Fibroblast Growth Factor 2; Humans; Insulin-like growth factor I; Osteoporosis; Ovariectomy; Rabbits; Treatment outcome; Up-Regulation

Alendronate regulates the activity of osteoclasts and healing of osteoporosis. This study investigated the effect of alendronate on bone healing and changes in the levels of cytokines. Bilateral ovaries of 10 adult female rabbits were removed surgically in aseptic condition to establish the animal model of osteoporosis. Five rabbits in group A were treated with alendronate (1.15 mg·kg·week) ... more

C.T. Liu; X.J. Yuan; G.C. Gao
03/30/2017
Adult; Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; Case-control studies; Female; Genetic association studies; Genetic predisposition to disease; Humans; Interleukin-17; Laryngeal Neoplasms; male; Middle Aged; Polymorphism, Single Nucleotide; Risk factors; Smoking

IL-17 is associated with the occurrence and development of laryngeal cancer. However, no study has reported the association between IL-17 polymorphisms and laryngeal cancer susceptibility. Therefore, we analyzed the association of three polymorphism loci (rs2275913, 197 G/A; rs3748067, 383 A/G; and rs763780, 7488 T/C) of IL-17A and IL-17F with laryngeal cancer in the Chinese population. A case ... more

F.Z. Si; Y.Q. Feng; M. Han
03/30/2017
Adult; Case-control studies; Chronic Disease; Female; Humans; Macrophages; male; Middle Aged; Periapical Diseases; Periapical Granuloma; Radicular Cyst; Transforming Growth Factor beta1

The objective of this study was to observe the distribution of macrophages (MPs) expressing transforming growth factor beta-1 (TGF-β1) in tissue samples from patients with different human chronic periapical diseases. In this study, samples were collected from 75 volunteers, who were divided into three groups according to classified standards, namely, healthy control (N = 25), periapical ... more

Z.Z. Liang; J. Li; S.G. Huang
03/30/2017
Aged; Aged, 80 and over; Alleles; Asian Continental Ancestry Group; Case-control studies; Ethnic groups; Gene frequency; Genetic predisposition to disease; Genetic variation; Haplotypes; Humans; male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt

AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated before. This study investigated the associations between three ... more

J.M. Liu; S.H. Cheng; C. Xia; T. Deng; Y.C. Zhu; X. Wei; Z.L. Huang; B.H. Liao; D.Y. Luo; Y.G. Zhang; T. Jin; K.J. Wang; J. Huang; H. Li
03/30/2017
Adult; Aged; Antineoplastic Agents; Caspase 3; Caspase Inhibitors; Disease-free survival; Everolimus; Female; Humans; Immunohistochemistry; Ki-67 Antigen; male; Middle Aged; Neuroendocrine Tumors; Protein Kinase Inhibitors

Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki-67 and caspase-3 in NET. ... more

H.Y. Zhang; X.B. Cheng; Y. Li; L.D. Jin; H.P. Yin
03/30/2017
Adult; Alleles; Brazil; Carrier Proteins; Case-control studies; Cation Transport Proteins; Diabetes, Gestational; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Humans; Leptin; Polymorphism, Single Nucleotide; Pregnancy

Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the ... more

A. Teleginski; M. Welter; H.R. Frigeri; R.R. Réa; E.M. Souza; D. Alberton; F.G.M. Rego; G. Picheth
03/30/2017
Alleles; Amelogenin; Asian Continental Ancestry Group; China; Chromosomes, Human, X; Chromosomes, Human, Y; DNA fingerprinting; Ethnic groups; Female; Forensic genetics; Gene frequency; Genetics, Population; Haplotypes; Humans; male; Microsatellite Repeats; Paternity; Polymorphism, Genetic

The sex-linked short tandem repeats (STR), Y-STR and X-STR, are important for autosomal STRs in forensic paternity testing. We evaluated the forensic parameters of 19 Y-STRs and 16 X-STRs in the Han population of Shandong province, China. A Goldeneye 20Y kit (DYS391, DYS389I, DYS390, DYS389II, DYS348, DYS456, Y-GATA-H4, DYS447, DYS19, DYS392, DYS393, DYS388, DYS439, DYS635, DYS448, DYS460, ... more

H.M. Gao; C. Wang; S.Y. Han; S.H. Sun; D.J. Xiao; Y.S. Wang; C.T. Li; M.X. Zhang
03/30/2017
Adult; Alleles; Case-control studies; European Continental Ancestry Group; Gene frequency; Genetic predisposition to disease; Humans; male; Middle Aged; Pilot Projects; Polymorphism, Single Nucleotide; Receptors, Tumor Necrosis Factor, Type I; Russia; Spondylitis, Ankylosing

The aim of this study was to assess the association between the TNFR1 rs2234649 polymorphism and ankylosing spondylitis susceptibility in a Russian Caucasian population. A total of 41 ankylosing spondylitis patients and 43 healthy controls, matched according to age and sex, were enrolled, and polymerase chain reaction-restriction fragment length polymorphism analysis was used to genotype the ... more

V. Mordovskii; A. Semenchukov; S.Y. Nikulina; A.B. Salmina; A. Chernova; E. Kapustina; A. Kents; A. Ohapkina; E. Moskaleva; P.E. Maltese; P. Convertini; M. Bertelli
04/05/2017
Arthritis, Rheumatoid; Gene expression profiling; Humans; Models, Genetic; Monte Carlo method; Signal transduction; Transcriptome

We attempted to identify significant pathway cross-talk in rheumatoid arthritis (RA) by the Monte Carlo cross-validation (MCCV) method. We therefore obtained and preprocessed the gene expression profile of RA. MCCV involves identifying differentially expressed genes (DEGs), identifying differential pathways (DPs), calculating the discriminating score (DS) of the pathway cross-talk, and random ... more

W. Song; Y.M. Zhang; T. Ma; J. Wang; K.Z. Wang

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