Research Article

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05/31/2017
Adult; Female; Glucuronides; Glucuronosyltransferase; Graft Rejection; Humans; Kidney transplantation; male; Middle Aged; Mycophenolic Acid; Polymorphism, Single Nucleotide; UDP-Glucuronosyltransferase 1A9

Mycophenolate mofetil (MMF) is a prodrug active only after its hydrolysis to mycophenolic acid (MPA). The UGT1A9 enzyme is of special interest since it is the main enzyme involved in the glucuronidation of MPA. Single nucleotide polymorphisms (SNPs) in the UGT1A9 gene may be responsible for individual differences in the pharmacokinetics of MMF. Expression levels and the activity of UGT1A9 may ... more

L.R. Ruschel; V.M. Schmitt; A.B. Silva; C.S.A. Oliveira; K. Flach; D.O. d'Avila; F.V. Thiesen
06/29/2017
Adolescent; Adult; Anemia, Sickle Cell; Child; Child, Preschool; Female; Gene Deletion; Haplotypes; Hemoglobins; Humans; male; Middle Aged; Polymorphism, Genetic; Receptors, CCR5

Sickle cell disease shows several clinical manifestations in distinct levels of severity. This heterogeneity is due to the haplotype variability associated with the HbS gene, levels of fetal hemoglobin and environmental conditions, which modify the disease expression. Science community believes that the presence of a polymorphism in the CCR5 gene, which is related to chronic inflammatory state ... more

A.F. Nascimento; J.S. Oliveira; J.C.Silva Junior; A.A.L. Barbosa
07/06/2017
Adult; Animals; Case-control studies; Dermatophagoides pteronyssinus; Female; Humans; Interleukin-18; male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Rhinitis, Allergic, Perennial; Thailand

Allergic rhinitis (AR) is an IgE-mediated inflammation of the nasal membranes, which is naturally triggered by aeroallergens. House dust mites (HDM) are the most common inhalant allergens. Interleukin-18 (IL-18) has been established as an essential cytokine that can activate the generation of IgE. This randomized controlled study aimed to identify the possible relationship of the genetic ... more

A. Tungtrongchitr; J. Jumpasri; N. Sookrung; N. Visitsunthorn; P. Tantilipikorn; O. Piboonpocanan; N. Indrawattana; R. Tungtrongchitr; W. Chaicumpa
08/17/2017
ADAMTS4 Protein; Adult; Biomarkers; Cartilage; Case-control studies; Female; Humans; male; MAP Kinase Kinase Kinases; Middle Aged; Tuberculosis, Spinal; Vascular cell adhesion molecule-1

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
08/17/2017
ADAMTS4 Protein; Adult; Biomarkers; Cartilage; Case-control studies; Female; Humans; male; MAP Kinase Kinase Kinases; Middle Aged; Tuberculosis, Spinal; Vascular cell adhesion molecule-1

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
09/21/2017
Adult; Brazil; Case-control studies; Diabetes Mellitus, Type 1; Female; Gene frequency; Glucose Transporter Type 4; Humans; Interleukin-18; male; Middle Aged; Polymorphism, Single Nucleotide; White People

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose ... more

Y. Al-Lahham; A.K.B. Mendes; E.M. Souza; D. Alberton; F.G.M. Rego; G. Valdameri; G. Picheth
3/30/2017
Aged; Aged, 80 and over; Alleles; Asian People; Case-control studies; Ethnicity; Gene frequency; Genetic predisposition to disease; Genetic variation; Haplotypes; Humans; male; Middle Aged; Polymorphism, Single Nucleotide; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt

AKT1, also known as v-akt murine thymoma viral oncogene homolog 1, is involved in the regulation of cell-survival and anti-apoptotic activities, which may affect the pathogenesis of various cancers. However, the association between genetic variants of AKT1 and the risk of developing prostate cancer has not been investigated before. This study investigated the associations between three ... more

J.M. Liu; S.H. Cheng; C. Xia; T. Deng; Y.C. Zhu; X. Wei; Z.L. Huang; B.H. Liao; D.Y. Luo; Y.G. Zhang; T. Jin; K.J. Wang; J. Huang; H. Li
05/10/2017
Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Immunoglobulins; male; Middle Aged; Neoplasm Metastasis; RNA, Messenger; Up-Regulation

The mRNA expression of cell adhesion molecule 1 (CADM1) and its clinicopathological significance in esophageal squamous cell carcinoma (ESCC) tissues were investigated. CADM1 mRNA and protein expression were detected in tissue samples from 50 patients with ESCC by reverse transcription-polymerase chain reaction (RT-PCR) and streptavidin-peroxidase (SP) immunohistochemistry; adjacent tissues ... more

J.B. Qian; H.B. Liu; Y. Zhu; F. Lu; Q.C. Yang; Y. Shen
2/23/2017
Blotting, Western; Cadherins; Cell Movement; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Hela cells; Humans; MicroRNAs; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; Uterine cervical neoplasms; Vimentin

Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate ... more

L. Zhang; H.E.X.D. Niyazi; H.R. Zhao; X.P. Cao; M.N.S. Abudula; W.J. Ye; S.A. Zhang; R.H.M. Yiming; Y. Zhang; W.P. Su; R. Chen; Y. Ouyang; N. Miao; Y.X. Bao
08/17/2017
Breast neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Down-regulation; Female; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; RNA, Messenger; Zinc Finger E-box-Binding Homeobox 1

The forkhead box F2 (Foxf2) gene suppresses epithelial-mesenchymal transition via the modulation of transcription of zinc finger E-box-binding homeobox 1 (Zeb1) and epithelial (E)-cadherin, thereby inhibiting tumor metastasis. Additionally, the specific binding of microRNA (miR)-200c to Foxf2 mRNA impedes metastatic pulmonary cancer. However, the role of miR-200c in breast cancer is still ... more

T. Zhang; J.G. Wan; J.B. Liu; M. Deng

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