Research Article

Related GMR Articles

2017 Jul 06
Asians; DNA, Mitochondrial; Haplotypes; Human Migration; Humans; Polymorphism, Genetic; Thailand

The lower northern part of Thailand contains various genetically diverse ethnic populations. The sequences of the mitochondrial DNA hypervariable region were studied in three ethnic populations inhabiting Phitsanulok Province. One hundred and nine nucleotide sequences - 53, 29, and 27 from Hmongs (Hill tribe), Lao Songs, and Thai-Siams, respectively - were collected. The haplotypes were ... more

U. Suyasunanont; M. Nakkuntod; S. Mirasena
08/17/2017
ADAMTS4 Protein; Adult; Biomarkers; Cartilage; Case-control studies; Female; Humans; male; MAP Kinase Kinase Kinases; Middle Aged; Tuberculosis, Spinal; Vascular cell adhesion molecule-1

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
8/17/2017
ADAMTS4 Protein; Adult; Biomarkers; Cartilage; Case-control studies; Female; Humans; male; MAP Kinase Kinase Kinases; Middle Aged; Tuberculosis, Spinal; Vascular cell adhesion molecule-1

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1 ... more

Z.X. Qiu; Z.S. Sha; X.M. Che; M.Y. Wang
8/17/2017
Cells, Cultured; DNA damage; Euterpe; Fruit; Hep G2 Cells; Humans; Lymphocytes; Plant Oils

Euterpe oleracea Mart., popularly known as "açaí", is a tropical fruit from the Amazon region where it has considerable economic importance. Açaí has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is a lack of data regarding the safety of using this fruit oil exclusively. Therefore, we evaluated the in vitro cytotoxic, genotoxic, and ... more

E.S. Marques; M.S.F. Tsuboy; J.C.T. Carvalho; P.C.P. Rosa; F.F. Perazzo; I.O.M. Gaivão; E.L. Maistro
8/17/2017
Alcohol Drinking; Atherosclerosis; Case-control studies; Diabetes mellitus; Humans; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Protein p53

Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or ... more

M.H. Lagares; K.S.F. Silva; A.M. Barbosa; D.A. Rodrigues; I.R. Costa; J.V.M. Martins; M.P. Morais; F.L. Campedelli; K.K.V.O. Moura
8/17/2017
Animals; Enterotoxigenic Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Feces; Humans; Molecular Diagnostic Techniques; Multiplex polymerase chain reaction; Sensitivity and Specificity; Water Microbiology

Diarrhea is considered the second most common cause of infant mortality worldwide. The disease can be caused by many different pathogens, including diarrheagenic Escherichia coli (DEC), which includes the pathotypes enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), enteroaggregative E. coli (EAEC), Shiga toxin-producing E. coli (STEC), and enteropathogenic E. coli (EPEC). To ... more

J.W. Vendruscolo; T.L. Waldrich; G.I.A. Saikawa; J.S. Pelayo; R.K.T. Kobayashi; G. Nakazato; S.P.D. Rocha
8/31/2017
Adult; Case-control studies; Female; Humans; Interleukin-17; Middle Aged; Polymorphism, Single Nucleotide; Uterine cervical neoplasms

Cervical cancer is a serious public health problem and is associated with high cancer-related mortality in females worldwide. The expression of IL17A can increase the migration and invasiveness of cervical cancer cells by activating the NF-κB signal pathway. Single-nucleotide polymorphisms (SNPs) can alter gene function and protein expression. We examined the association between two IL17A SNPs ... more

A.Q. Niu; Y.H. Cao; H. Wang; X. Zhang; B. Zhu; Z.H. Li
8/31/2017
Apolipoproteins B; Brazil; Genetic testing; Humans; Hyperlipoproteinemia Type II; Introns; Mutation, Missense; Proprotein Convertase 9; Receptors, LDL

Familial hypercholesterolemia (FH) is a dominant, autosomal disease characterized by high LDL levels in blood plasma, and is caused by a defect in the gene encoding the LDL receptor (LDLR). The clinical diagnosis is based on personal and familial history, physical examination findings, and measures of high LDL cholesterol concentrations. LDLR is a cell-surface glycoprotein that controls the ... more

G.A. Molfetta; D.L. Zanette; J.E. Santos; W.A. Silva
8/31/2017
Cell Line, Tumor; Cell Movement; Cell proliferation; Down-regulation; Glioma; Humans; MicroRNAs

Neuroglioma is associated with high rates of malignancy, metastasis, and recurrence. Recently, research on the roles of microRNAs (miR) in cancer prognosis has formed an important area of research as differential expression of miRNAs has been observed in different cancers. However, the detailed mechanism by which miRNAs regulate glioma remains unknown. Thus, we investigated the effect of miR-1 ... more

Y.Q. Wang; Y. Cai; X.M. Zhong
9/21/2017
Adult; Case-control studies; Coronary artery disease; Female; Humans; male; Mutation, Missense; Nitric Oxide Synthase Type III; Polymorphism, Genetic

The coronary arteriosclerotic disease is the most common cardiovascular disease. Atherosclerosis affects large- and medium-sized arteries leading to severe thrombosis or artery stenosis that could evolve to myocardial infarction, ischemic stroke, ischemic injury of kidneys and intestines, and several other life-threatening clinical manifestations. Nitric oxide has been shown to be a promising ... more

A.M. Barbosa; K.S.F. Silva; M.H. Lagares; D.A. Rodrigues; I.R. da Costa; M.P. Morais; J.V.M. Martins; R.S. Mascarenhas; F.L. Campedelli; K.K.V.O. Moura

Pages