Research Article

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Glioblastoma; ionizing radiation; MicroRNAs; miR-21; Neurospheres; Temozolomide

Glioblastomas are the most common primary malignant brain tumors, and despite current advances in therapy, they are still extremely resistant to treatment. The tumorigenic potential of glioblastomas is due to a subpopulation of neoplastic cells, called cancer stem cells (CSCs), which in culture form a suspension cluster called neurospheres. Their properties include ... more

A.R. Rodrigues; F.S.L. Neto; L.G. Lourenço; F.A. Trevisan; M.L.A. Cirino; B. Nery; F.M. Peria; G. Pereira-da-Silva; M.F.G.S. Tazima; L.F. Tirapelli; D.G. Tiezzi; C.G.Carlotti Junior; D.P.C. Tirapelli
meningiomas; MicroRNAs; Serum

Meningiomas are the most common primary tumors of the central nervous system, accounting for 35.5% of cases, considering all age groups. Despite progress made in recent decades, tumorigenesis of meningiomas still remains a challenge. There is a consensus of a need for molecular tools to assist in diagnosis and prognosis of meningiomas. In this context, some studies ... more

M.S.T. Rosa; F. Pansani; F.O. Buono; M.F.B.M. Tiezzi; L.P. Turra; F.S.Lizarte Neto; P.C. Novais; M.F.G.S. Tazima; F.M. Peria; V.M. Carneiro; M.L.A. Cirino; L.F. Tirapelli; B.O. Colli; C.G.Carlotti Junior; D.P.C. Tirapelli
Apoptosis; Epilepsy; Hippocampus; MicroRNA; Status epilepticus

Epilepsy is one of the most frequent neurological disorders. Recently, the regulation of microRNAs was found to be associated with epilepsy, but the molecular mechanism by which microRNA influences epilepsy process remains to be unveiled and the development of microRNA-based therapy requires more intensive research. In this study, five microRNAs with potential relevance to epilepsy were ... more

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C6 glioma cells; Cytokines; Midazolam

The current study was performed to investigate the effects of midazolam on immune function in pediatric patients after surgery and possible mechanism involved. Patients who needed sedation for more than 2 consecutive days after undergoing surgery in the Pediatric Surgery Department of our hospital were enrolled for the study. Fifty-six patients (5-14 years old) were randomly divided into ... more

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Cytokines; HaCaT cells; Irradiation; Th cells

We have previously found that an imbalance of Tc1/Tc2 T cell subtypes in vivo impacts the development of photodermatitis. The aim of this study was to investigate the relationship between cytokines derived from keratinocytes exposure to UV and the imbalance of Th subgroups. We used different doses of UVA and UVB to irradiate HaCaT cells. Twelve hours after irradiation, the ... more

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Cytokines; Flurbiprofen axetil; Immunosuppressive; Morphine; Tramadol

We explored the effects of flurbiprofen axetil on interleukin (IL)-2 and IL-6 levels in postoperative patients with colorectal cancer. A total of 120 patients (American Society of Anesthesiologists I and II) scheduled to undergo colorectal cancer surgery were randomly divided into 3 groups (N = 40 in each group): flurbiprofen axetil group (group F), morphine group (group M), and tramadol ... more

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Adiponectin; Cytokines; Hemorrhagic shock; Inflammation; Mean arterial pressure; Serum

The aim of this study was to explore the relationship between adiponectin (ADPN) and hemorrhagic shock (HS) and the recovery after HS. This is significant for further understanding of the pathophysiological processes of HS and the development of better treatments. In total, 72 male C57BL/6 mice were assigned randomly to three groups: control, HS, and recovery (N = 24). The HS mouse model ... more

X. Gong; Y. Liu; S. Yao; J.F. Zheng; F. Wan; X.D. Xiang; X.P. Chai; X. Gong; Y. Liu; S. Yao; J.F. Zheng; F. Wan; X.D. Xiang; X.P. Chai
Cytokines; Hepatotoxicity; Nephrotoxicity; Royal jelly; Valproic acid

Valproic acid (VPA) is a drug that is often used to treat epilepsy, seizures, and similar diseases. However, it is known to have serious toxic effects on the liver and the kidney. Oxidative stress and other metabolites of VPA have been suggested to be responsible for VPA induced hepatotoxicity and nephrotoxicity. We evaluated the possible protective role of royal ... more

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Asian People; Child; Chromosome Deletion; Chromosomes, Human, Pair 2; Fingers; Heart Defects, Congenital; Hedgehog Proteins; Humans; Karyotype; male; Syndactyly; Waardenburg Syndrome

Reports of terminal and interstitial deletions of the long arm of chromosome 2 are rare in the literature. Here, we present a case report concerning a Chinese boy with a 47,XYY karyotype and a de novo deletion comprising approximately 5 Mb between 2q35 and q36.1, along with syndactyly, type III Waardenburg syndrome, and congenital heart disease. High-resolution chromosome analysis to detect ... more

D. Wang; G.F. Ren; H.Z. Zhang; C.Y. Yi; Z.J. Peng