Research Article

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2017 Mar 22
Animals; Cryopreservation; Disease Models, Animal; Glial cell line-derived neurotrophic factor; Interleukin-10; male; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Neuroprotective Agents; Rats; Rats, Inbred Lew; Regenerative medicine; Spinal Cord Injuries; Transforming Growth Factor beta; Tumor necrosis factor-alpha; Vascular Endothelial Growth Factor A

This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following groups: negative control (NC) - without injury, positive control (PC) - with injury without treatment, and group treated with MSC (GMSC) - with injury and treated. Motor ... more

I.R. Rosado; P.H. Carvalho; E.G.L. Alves; T.M. Tagushi; J.L. Carvalho; J.F. Silva; M.S.L. Lavor; K.M. Oliveira; R. Serakides; A.M. Goes; E.G. Melo
Animals; Aquaculture; Cichlids; Ethanol; Fish Proteins; Gene Expression Regulation; male; Muscle, Skeletal; Myostatin; Organ Size; Plant Extracts; Propolis

Propolis can be used as growth enhancer due to its antimicrobial, antioxidant, and immune-stimulant properties, but its effects on morphometry and muscle gene expression are largely unknown. The present study evaluates the influence of propolis on muscle morphometry and myostatin gene expression in Nile tilapia (Oreochromis niloticus) bred in net cages. Reversed males (GIFT strain) with an ... more

E.L. Buck; I.Y. Mizubuti; A.A. Alfieri; R.A.A. Otonel; L.Y. Buck; F.P. Souza; O.P. Prado-Calixto; A.R. Poveda-Parra; A. Filho; N.M. Lopera-Barrero
3-Nitrotyrosine; Alzheimer disease; Mini-Mental State Examination; Nitrative stress; Oxidized low-density lipoprotein

To examine the expression and clinical significance of plasma 3-nitrotyrosine (3-NT) and oxidized low-density lipoprotein (ox-LDL) levels in patients with Alzheimer's disease (AD), we examined 48 AD patients and 37 healthy control subjects. The Mini-Mental State Examination, Activities of Daily Living Scale, and Hachinski Ischemic Scale were examined in all subjects. AD patients were ... more

Z. Zhao; H. Zhou; Y. Peng; C.H. Qiu; Q.Y. Sun; F. Wang; H.N. Xie
Alzheimer disease; Apolipoprotein E; BMAL1 rs2278749T/C; Case-control study; Genetic risk factor; Metabolism; Polymorphism; susceptibility

In the present study, we examined whether the ARNTL (BMAL1) rs2278749 T/C polymorphism was associated with the susceptibility to Alzheimer disease (AD). This case-control study examined the genotypes of apolipoprotein E (APOE e4) and BMAL1 rs2278749 T/C using restriction fragment length polymorphism and the TaqMan assay, respectively. A total of 296 ... more

Q. Chen; X.D. Peng; C.Q. Huang; X.Y. Hu; X.M. Zhang
Expressed exotoxin; Mice; Protection efficacy; Subunit bacterin

The exotoxin SLT-IIeB from the Escherichia coli Ee strain was expressed in E. coli, and the recombinant protein was purified, mixed with the Ee strain, then emulsified with oil-emulsion adjuvants to obtain a mixed subunit bacterin. Groups of Kunming mice were immunized at weeks 0 and 2, and challenged intraperitoneally with the Ee strain at week 4. Antibodies were ... more

X.L. Yang; Y.J. Liu; L.Q. Hu; L.W. Guo; G.P. Liu; B. Wu; H.C. Chen
Antibody array; Cytokine; Disease marker; Mice; Staphylococcus hyicus

Staphylococcal infection is a severe bacterial infection. Finding satisfactory predictable biological markers is essential for the treatment of this condition. In this study, we applied a 32-marker sandwich ELISA-based antibody array to evaluate cytokine changes in Staphylococcus hyicus-inoculated BALB/c mice at 24 and 48 h post infection. Among the cytokines detected, the expression ... more

Y. Li; L. Wang; L.Y. Zhang; Y.L. Liu; Z.Y. Jiang; R.J. Cai; C.X. Song
Development; Early embryo; Luman; Mice; Oocyte

Luman/CREB3 is a transcription factor that is a member of the cAMP-response-element-binding protein family of basic region-leucine zipper transcription factors. This protein interacts with host cell factor 1, which also associates with the herpes simplex virus protein VP16 to induce the transcription of herpes simplex virus. Currently, the physiological function of Luman/CREB3 in ... more

T.N. Mahmoud; P.F. Lin; F.L. Chen; J.H. Zhou; X.G. Wang; N. Wang; X. Li; Y.P. Jin
Cardiomyocytes; Heart failure; Mice; Protein 4.1R

We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdominal subcutaneous injection of 5 mg⋅kg-1⋅day-1 ... more

Z. Wei; G. Yang; R. Xu; C. Zhu; F. He; Q. Dou; J. Tang; Z. Wei; G. Yang; R. Xu; C. Zhu; F. He; Q. Dou; J. Tang
Angiogenic factors; COH; Endometrial blood vessel; Endometrial receptivity; Mice; YGW
Purpose: To explore the mechanism of You-Gui-Wan
(YGW) in improving endometrial receptivity in mouse model of
controlled ovarian hyperstimulation (COH).
Methods: Sixty female mice with two consecutive oestrous cycles
were randomly divided into COH model group (n = 50) and normal
control group (n = 10). The COH model was created by using ... more
Qzhi Yin; J.Zhong Zhang; Lmin Li; Ylin Li; L. Huang; N. Ning
Diagnosis; Meta-analysis; MicroRNAs; Thyroid cancer

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive ... more

G.J. Zhou; M. Xiao; L.N. Zhao; J.G. Tang; L. Zhang