Research Article

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4/05/2017
Adult; Alleles; Asian People; Case-control studies; China; Female; Gene frequency; Genetic association studies; Genetic predisposition to disease; Humans; Interleukin-4; Polymorphism, Single Nucleotide; Pre-eclampsia; Pregnancy; Risk factors

Preeclampsia is a common disease unique to pregnant women, and its development involves many genetics l factors. IL-4 is an important regulatory factor of the Th2 cellular immune response, and plays an important role in the induction of placental growth. In this study, we investigated the relationship between IL-4 C-590T, C+33T and G-1098T polymorphisms and risk of pre-eclampsia in a ... more

J. Chen; M. Zhong; Y.H. Yu
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Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Child; Child, Preschool; China; Duffy Blood-Group System; Female; Gene frequency; Genotype; Humans; Infant; Kell Blood-Group System; male; Middle Aged; MNSs Blood-Group System; Young Adult

Human blood groups are a significant resource for patients, leading to a fierce international competition in the screening of rare blood groups. Some rare blood group screening programs have been implemented in western countries and Japan, but not particularly in China. Recently, the genetic background of ABO and Rh blood groups for different ethnic groups or regions in China has been focused ... more

G.Y. Lin; X.L. Du; J.J. Shan; Y.N. Zhang; Y.Q. Zhang; Q.H. Wang
12/19/2016
Aged; Asian People; Case-control studies; Female; Genetic predisposition to disease; Humans; Interleukin-10; male; Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Stomach neoplasms

We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction- ... more

L. Li; X.Y. Tang; L.M. Ye; Q. Yang; Y. Li
12/19/2016
Adult; Aggrecans; Asian People; Case-control studies; Female; Genetic predisposition to disease; Humans; Intervertebral disc degeneration; Intervertebral Disc Displacement; male; Middle Aged; Minisatellite Repeats; Young Adult

We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 80 to the control group (Ct). We gathered sociodemographic and clinical ... more

N.L.L. Casa; A.J.Casa Junior; A.V. Melo; L.S. Teodoro; G.R. Nascimento; A.F. Sousa; T.C. Flausino; D. Brito; R. Bergamini; L.B. Minasi; A.D. da Cruz; T.C. Vieira; M.P. Curado
4/20/2017
Adolescent; Adult; Alleles; Case-control studies; China; Female; Genotype; Humans; Interleukin-6; Keloid; male; Middle Aged; Polymorphism, Single Nucleotide

The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated ... more

X.J. Zhu; W.Z. Li; H. Li; C.Q. Fu; J. Liu
07/06/2017
Aged; Case-control studies; China; Endothelin-1; Female; Gene frequency; Humans; Hypertension; male; Middle Aged; Mutation, Missense; Polymorphism, Single Nucleotide

Endothelin-1 (ET-1) is the most potent endogenous vasoconstrictor and is involved in several vascular disorders such as hypertension. Its strong interaction with other vasoactive hormone systems suggests that the ET-1 gene (EDN1) is a potential candidate molecule that influences the risk of developing hypertension. Recently, two single nucleotide polymorphisms in EDN1 have been reported to be ... more

Z. Fang; M. Li; Z. Ma; G. Tu
09/21/2017
Adult; Brazil; Case-control studies; Diabetes Mellitus, Type 1; Female; Gene frequency; Glucose Transporter Type 4; Humans; Interleukin-18; male; Middle Aged; Polymorphism, Single Nucleotide; White People

Type 1 diabetes (T1D) is an autoimmune disease with a strong genetic component that has been associated with several genetic loci. Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is involved in the innate and adaptive immune responses, and in the pathogenesis of various diseases including T1D. Glucose transporter 4 (GLUT4) is known to be an insulin-responsive glucose ... more

Y. Al-Lahham; A.K.B. Mendes; E.M. Souza; D. Alberton; F.G.M. Rego; G. Valdameri; G. Picheth
12/19/2016
Adult; Aromatase; Asian People; Case-control studies; Endometriosis; Female; Genetic predisposition to disease; Genotype; Glutathione S-Transferase pi; Glutathione transferase; Humans; Polymorphism, Single Nucleotide; Young Adult

Endometriosis is a common, complicated, and highly heterogeneous endocrine disease. Many genetic factors could affect the development of endometriosis. We performed a case-control study to evaluate the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis in a Chinese population. Between March 2014 and October 2015, 262 ... more

Y. Tuo; J.Y. He; W.J. Yan; J. Yang
12/19/2016
Adult; Arginine; Asian People; Case-control studies; Collagen Type IX; Female; Genetic predisposition to disease; Glutamine; Humans; Intervertebral disc degeneration; Intervertebral Disc Displacement; male; Middle Aged; Mutation

Intervertebral disc disease is a multifactorial condition, yet disease pathogenesis that can be promoted by a single dominant mutation affecting the expression of susceptibility genes. We performed a case-control study to assess the influence of the COL9A2 Gln326Arg polymorphism on risk of intervertebral disc disease in a Chinese population. Between March 2014 and March 2015, a total of 215 ... more

T. Meng; Q. Ren; J.M. Wang; H. Shi; S.T. Zhang; M.T. Liu
09/27/2017
Acute coronary syndrome; Aged; Case-control studies; Female; Genotype; Heterozygote; Humans; male; Mexico; Middle Aged; Peptidyl-Dipeptidase A; Polymorphism, Single Nucleotide

Acute coronary syndrome (ACS) is considered one of the main causes of death worldwide. Contradictory findings concerning the impact of the angiotensin-converting enzyme (ACE) gene on cardiovascular diseases have been reported. Previous conclusions point out that the variability in results depends on ethnicity and genetic polymorphisms to determine the association of rs4340 polymorphisms of the ... more

A. Valdez-Haro; Y. Valle; E. Valdes-Alvarado; F. Casillas-Muñoz; J.F. Muñoz-Valle; G.L. Reynoso-Villalpando; H.E. Flores-Salinas; J.R. Padilla-Gutiérrez

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