Research Article

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12/02/2016
Female; Humans; Macrophage Activation; Macrophages; male; Prognosis; Proportional Hazards Models; Stomach neoplasms; Survival rate

Tumor-associated macrophages (TAMs), which play a crucial role in the tumor microenvironment, can be divided into M1 and M2 phenotypes, these phenotypes may exert opposite effects on the prognoses of patients with gastric cancer (GC). The association between TAMs and GC is contentious. Thus, a meta-analysis of 12 studies (incorporating 1388 patients) retrieved from the Cochrane Library, PubMed ... more

X.L. Wang; J.T. Jiang; C.P. Wu
12/02/2016
Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Cell proliferation; Female; Fibroblast growth factor 1; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Hela cells; Humans; Middle Aged; Neoplasm Staging; Prognosis; Uterine cervical neoplasms; Young Adult

Fibroblast growth factors (FGFs) play important roles in angiogenesis, wound healing, embryonic development, and endocrine signaling pathways. Increasingly, recent studies have reported aberrant FGF expression in various malignancies. However, the involvement of FGFs in cervical carcinoma pathogenesis remains unclear. We aimed to investigate expression of acidic (aFGF) and basic FGF (bFGF) in ... more

Q.H. Zhang; P. Xu; Y.X. Lu; H.T. Dou
12/02/2016
Abortion, Spontaneous; Azoospermia; Chromosome Breakpoints; Chromosomes, Human, Pair 4; Female; Genetic counseling; Heterozygote; Humans; male; Oligospermia; Pregnancy; Translocation, Genetic

Cytogenetic analysis remains a powerful and cost-effective technology, and has wide applicability in genetic counseling for infertile males. Chromosomal rearrangements are thought to be one of the major genetic factors that influence male infertility. Some carriers with balanced reciprocal translocation have been identified as having oligozoospermia or azoospermia, and there is an association ... more

H.G. Zhang; R.X. Wang; Y. Pan; J.H. Zhu; L.T. Xue; X. Yang; R.Z. Liu
12/02/2016
Cesarean section; Chromosomes, Human, Pair 14; Cytogenetic Analysis; Female; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Limb Deformities, Congenital; male; Mosaicism; Pregnancy; Trisomy

Complete trisomy 14 mosaicism is a rare chromosome disorder and was first reported in 1970. We describe a case of a male neonate who presented complete trisomy 14 mosaicism in only 4% of the cells from peripheral blood. A nineteen-day-old male neonate was born as result of the second pregnancy. The infant was delivered by cesarean section due to gestational hypertension and chronic fetal ... more

M.A. Rodrigues; L.F. Morgade; L.F.A. Dias; R.V. Moreira; P.D. Maia; A.F.H. Sales; P.D. Ribeiro
12/19/2016
Athletes; Cell Hypoxia; Cell proliferation; Cells, Cultured; Endothelial progenitor cells; Exercise; Gene expression; Humans; Lipoproteins; Skiing

In this study, we compared the functional properties of endothelial progenitor cells (EPCs) derived from halfpipe-snowboarding athletes who train under hyperoxic conditions with those derived from normal subjects who lived under normoxic conditions. Peripheral blood-derived EPCs were isolated from both halfpipe-snowboarding athletes and normal humans. Cellular growth dynamics, lipoprotein ... more

Y.H. Zhao; J.C. Kan; Y.F. Wang; W.J. Guan; Z.Q. Zhu
12/19/2016
Aged; Asian People; Case-control studies; Female; Genetic predisposition to disease; Humans; Interleukin-10; male; Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Stomach neoplasms

We conducted a case-control study to investigate the association between the interleukin-10 (IL-10) C819T polymorphism and susceptibility to gastric cancer in a Chinese population. A total of 157 patients with gastric cancer and 249 controls were consecutively enrolled from the Guizhou Provincial People's Hospital between October 2012 and February 2015. The polymerase chain reaction- ... more

L. Li; X.Y. Tang; L.M. Ye; Q. Yang; Y. Li
12/19/2016
Aged; Asian People; Carcinoma, Non-Small-Cell Lung; China; Female; Genetic predisposition to disease; Humans; Interferon-gamma; Interleukin-18; Lung Neoplasms; male; Middle Aged; Polymorphism, Single Nucleotide; Tumor necrosis factor-alpha

Lung cancer is one of the main causes of cancer-related mortality in males and females worldwide. A pleiotropic effect has been observed in the interleukin 18 gene (IL18); its effects include the activation of natural killer cell cytotoxicity and the promotion of the Th1 immune response through the alteration of the expression of interferon-γ and TNF-α in humans. IL18 is therefore involved in ... more

W.Y. Gan; H.M. Li; Y.G. Zhang; C.M. Li; Y. Wang
12/19/2016
Adult; Aggrecans; Asian People; Case-control studies; Female; Genetic predisposition to disease; Humans; Intervertebral disc degeneration; Intervertebral Disc Displacement; male; Middle Aged; Minisatellite Repeats; Young Adult

We investigated the association between an aggrecan gene (ACAN) polymorphism and lumbar disc herniation (LDH). This was a case-control study with quinquennial age and gender groups. The study comprised 119 men and women aged between 20 and 60 from Goiânia (Brazil). Of these, 39 were allocated to the case group (Ca) and 80 to the control group (Ct). We gathered sociodemographic and clinical ... more

N.L.L. Casa; A.J.Casa Junior; A.V. Melo; L.S. Teodoro; G.R. Nascimento; A.F. Sousa; T.C. Flausino; D. Brito; R. Bergamini; L.B. Minasi; A.D. da Cruz; T.C. Vieira; M.P. Curado
12/19/2016
Adult; Aged; Apoptosis; Bone neoplasms; Caspase 8; Cell proliferation; Cell survival; Female; Gene Expression Regulation, Neoplastic; Humans; male; Middle Aged; Osteochondroma; Osteosarcoma; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Young Adult

Osteosarcoma is a common malignant bone tumor that mainly affects children and adolescents. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily. Caspase-8 appears in the upstream of apoptosis signaling pathway among caspases. We investigated TRAIL and caspase-8 levels in osteosarcoma patients to determine their correlation with ... more

X. Ning; X.W. Shang; Y. Zhuang; M. Liu; H. Yang; H. Zhang; M.Z. Huang
12/19/2016
Adult; China; Female; Fetal Growth Retardation; Folic acid; Folic Acid Deficiency; Gestational age; Homocysteine; Humans; Infant, Newborn; Pregnancy; Vitamin B 12; Vitamin B 12 Deficiency; Young Adult

Deficiencies in nutrients such as folic acid and vitamin B12 may play a role in fetal growth restriction (FGR). However, whether folic acid, vitamin B12, or homocysteine is associated with FGR in Chinese populations remains unclear. This study investigated the relationship between these nutrient deficiencies and FGR in pregnant Chinese women. We selected 116 mother and infant pairs, and ... more

H.L. Jiang; L.Q. Cao; H.Y. Chen

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