Research Article

Related GMR Articles

2/08/2017
alpha-Fetoproteins; Animals; Disease Models, Animal; Gene expression; Glypicans; Humans; Liver neoplasms; male; Neoplasm Micrometastasis; Polymerase chain reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger

The incidence of liver cancer has gradually risen to a high level in China, and tumor metastasis occurs via multiple pathways. Alpha fetal protein (AFP) is the main biomarker of liver cancer micrometastases. A recent study showed that glypican-3 (GPC3), which is abundant in hepatoma cells, has promising specificity and could be used to determine the presence of malignant cells. The nested ... more

J. Luo; K. Yang; Y.G. Wen
12/02/2016
Animals; Citalopram; Dementia, Vascular; Disease Models, Animal; Dopamine; Gene Expression Regulation; Hippocampus; Humans; Injections, Intraperitoneal; male; Neurons; Norepinephrine; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Serotonin; Treatment outcome

5-hydroxytryptamine receptor 1A (5-HT1AR) is closely associated with cognitive functions. Selective serotonin reuptake inhibitors (SSRIs) can protect individuals from brain damage following ischemia/hypoxia. To investigate the function of SSRIs in vascular dementia (VD), we established a rat model of VD, and observed the effect of SSRIs on the expression of 5-HT1AR mRNA and neurotransmitters. ... more

K. Guo; G. Yin; X.H. Zi; H.X. Zhu; Q. Pan
2/16/2017
Alzheimer disease; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Humans; Maze Learning; Mice; MicroRNAs; Receptor, Cannabinoid, CB2

Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 ... more

Y. Tang; J.S. Bao; J.H. Su; W. Huang
12/02/2016
Administration, Oral; Animals; Bone marrow cells; Cell proliferation; Cells, Cultured; Guatemala; Humans; Lymphocytes; male; Mexico; Micronucleus tests; Mutagenicity Tests; Plant Extracts; Rats; Rubus; Sister chromatid exchange; Toxicity Tests, Subchronic

Rubus coriifolius Focke is a wild plant from the Rosaceae family. It grows in both Guatemala and Mexico. The polar extract of the aerial parts of this plant has antibacterial, anti-inflammatory, and anti-protozoal activities. These properties may explain the traditional use of this plant. In vivo and in vitro assays were used to assess the genotoxic and toxic effects of an ethanol extract of ... more

S. González-Hernández; D. González-Ramírez; M.I. Dávila-Rodríguez; A. Jimenez-Arellanez; M. Meckes-Fischer; S. Said-Fernández; E.I. Cortés-Gutiérrez
1/23/2017
Animals; Biomarkers; Drugs, Chinese Herbal; Endometrium; Estrous cycle; Female; Flavonoids; Immunohistochemistry; Rats

This study aimed to investigate the effect of icariin (ICA) on thin endometrium in a rat model. To this end, 6- to 8-week-old female Sprague Dawley rats (105) were randomly divided into 7 groups: untreated, vehicle-treated (lavage with NaCl), high-dose ICA (lavage with ICA at 200 mg∙kg∙day), medium-dose ICA (lavage ICA at 100 mg∙kg∙day), low-dose ICA (lavage with ICA at 50 mg∙kg∙day), sham ... more

A.W. Le; Z.H. Wang; X.Y. Dai; T.H. Xiao; R. Zhuo; B.Z. Zhang; Z.L. Xiao; X.J. Fang
2/08/2017
Animals; DNA damage; DNA Fragmentation; Female; Ferric Compounds; Humans; Lipid peroxidation; Lymphocytes; Metal Nanoparticles; Oxidative stress; Rats; Reactive oxygen species; Silicon Dioxide

At present, the use of nanoparticles is a controversial topic, especially when analyzing their effects in human tissues. Nanoparticles (NPs) can cause oxidative stress by increasing membrane lipids peroxidation and reactive oxygen species, and decreasing intracellular glutathione. Oxidative stress plays an important role in cell signaling and inflammatory responses. It can result in ... more

J. Jiménez-Villarreal; D.I. Rivas-Armendáriz; R.D.Arellano Pérez-Vertti; O. Calderón; R. García-Garza; N.D. Betancourt-Martínez; L.B. Serrano-Gallardo; J. Morán-Martínez
2/16/2017
Acetylation; Animals; Aspartate Aminotransferases; Blueberry Plants; Carbon Tetrachloride; Disease Models, Animal; Histones; Liver cirrhosis; Liver Function Tests; male; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley

The objective of this study was to investigate the effects of blueberry treatment on histone acetylation modification of carbon tetrachloride (CCl)-induced liver disease in rats. Laboratory rats were randomly divided into control, hepatic fibrosis, blueberry treatment, blueberry intervention, and natural recovery groups. Rats in the model groups were treated with CCl administered ... more

W. Zhan; X. Liao; T. Tian; L. Yu; X. Liu; B. Li; J. Liu; B. Han; R.J. Xie; Q.H. Ji; Q. Yang
3/22/2017
Animals; Cryopreservation; Disease Models, Animal; Glial cell line-derived neurotrophic factor; Interleukin-10; male; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Neuroprotective Agents; Rats; Rats, Inbred Lew; Regenerative medicine; Spinal Cord Injuries; Transforming Growth Factor beta; Tumor necrosis factor-alpha; Vascular Endothelial Growth Factor A

This study aimed to evaluate the immunomodulatory and neuroprotective effects of allogeneic and cryopreserved mesenchymal stem cells (MSCs) on spinal cord injury. A total of 120 rats were distributed into the following groups: negative control (NC) - without injury, positive control (PC) - with injury without treatment, and group treated with MSC (GMSC) - with injury and treated. Motor ... more

I.R. Rosado; P.H. Carvalho; E.G.L. Alves; T.M. Tagushi; J.L. Carvalho; J.F. Silva; M.S.L. Lavor; K.M. Oliveira; R. Serakides; A.M. Goes; E.G. Melo
3/16/2017
Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Leukocytes; male; Mangifera; Medicine, Traditional; Mice; Oils, Volatile; Peroxidase; Plant Leaves; Plant Oils; Rats

Mangifera indica is widely found in Brazil, and its leaves are used as an anti-inflammatory agent in folk medicine. The aim of this study is to perform composition analysis of essential oils from the M. indica varieties, espada (EOMIL1) and coração de boi (EOMIL2), and confirm their anti-inflammatory properties. Twenty-three volatile compounds were identified via gas chromatography-mass ... more

R.M. Oliveira; T.S. Dutra; E. Simionatto; N. Ré; C.A.L. Kassuya; C.A.L. Cardoso
12/02/2016
Animals; Avian Proteins; Body weight; Breeding; Chickens; Female; Gene expression; Gene Expression Regulation; male; Muscle development; Myostatin; Organ Specificity; Phenotype; Quantitative trait loci

Myostatin (MSTN) is expressed in the myotome and developing skeletal muscles, and acts to regulate the number of muscle fibers. Wuding chicken large body, developed muscle, high disease resistance, and tender, delicious meat, and are not selected for fast growth. Broiler chickens (Avian broiler) are selected for fast growth and have a large body size and high muscle mass. Here, 240 one-day-old ... more

L.X. Liu; T.F. Dou; Q.H. Li; H. Rong; H.Q. Tong; Z.Q. Xu; Y. Huang; D.H. Gu; X.B. Chen; C.R. Ge; J.J. Jia

Pages