Research Article

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Gastric adenocarcinoma; Telomerase activity; Tumor progression

Telomerase activity is responsible for telomere maintenance and is believed to be crucial in most immortal cells and cancer cells; however, its clinicopathological significance in gastric cancer remains to be clarified. The aim of the present study was to assess whether malignant progression of gastric adenocarcinoma correlates with telomerase activity. We also investigated the ... more

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Biomarker; Bladder cancer; Dickkopf-1; Prognosis

Dickkopf-1 (DKK-1) is a secreted protein that inhibits Wnt signaling. However, the clinical significance and prognostic value of serum DKK-1 levels have not been previously investigated in bladder cancer in Chinese patients. Blood samples were taken from 94 consecutive patients diagnosed with bladder cancer and 60 healthy control subjects. Serum DKK-1 expression levels were measured by ... more

D.K. Sun; L. Wang; J.M. Wang; P. Zhang
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Bladder cancer; NAT2; NAT2 slow acetylation

The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studies have failed to prove this. This study ... more

Y. An; H. Li; K.J. Wang; X.H. Liu; M.X. Qiu; Y. Liao; J.L. Huang; X.S. Wang
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Biomarker; Bladder cancer; MicroRNA-100; Prognosis

We investigated the clinical significance and prognostic value of microRNA-100 (miR-100) in bladder cancer. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-100 in 92 pairs of human bladder cancer and adjacent normal tissue samples. Overall survival (OS) curves were plotted using the Kaplan-Meier method and were evaluated for statistical ... more

Y.H. Cao; H.H. Zhang; H.F. Xu; Y.J. Duan; Q. Li; B. Huang
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Bladder cancer; Gene polymorphism; PCR-RFLP; Toll-like receptor

In this study, the association between the 729G/C polymorphism in Toll-like receptor 4 (TLR4) and the risk of bladder cancer was investigated. A total of 376 patients with bladder cancer and 380 healthy volunteers from the Third Xiangya Hospital of Central South University (China) were enrolled in this study between January 2008 and February 2014. The TLR4-729G/C polymorphism was ... more

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11/23/2015
Bladder cancer; Meta-analysis; MYC; rs9642880[T] allele

A single nucleotide polymorphism of MYC rs9642880 (G>T) at the 8q24.1 locus is thought to be associated with bladder cancer risk based on the results of genome-wide association studies, but the results remain inconclusive. To assess the association between rs9642880[T] allele and bladder cancer risk, we performed this meta-analysis including 18 case-control studies and ... more

Y. Zhao; J.G. Qi; N. Yang; Y.L. Lin; J. Liang; X. Zhu
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Bladder cancer; CYP1A2; Polymorphism; Risk

To date, no study has investigated the association between CYP1A2-163C/A polymorphism and bladder cancer risk in a Chinese population. Here, we extracted genomic DNA from peripheral white blood cells, and differentiated CYP1A2 alleles by polymerase chain reaction-based restriction fragment length polymorphism methods. Differences in genotype frequencies between the cases ... more

Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu; Y.L. Song; L. Wang; J.C. Ren; Z.H. Xu
11/03/2016
Age distribution; Cervical cancer; Human papilloma virus; Multiple infection; Subtype distribution

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection ... more

J. Li; Y.Y. Wang; X.F. Tian; X. Nan; T. Yan; P. Wang; Y.L. Fu; G.Q. Wang
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Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
11/03/2016
Deciduous teeth; Pathway analyses; Pathway-related modules; Permanent teeth; Reverse transcription-polymerase chain reaction

The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly different modules between permanent and deciduous teeth via network and pathway analyses. We ... more

J. Kang; R. Bai; K. Liu; X.P. Ji; Y. Li; J.Y. Han

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