Research Article

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10/24/2016
Autoimmunity; CD40; qPCR; Rheumatoid arthritis; SNP

The CD40 pathway is involved in the development and pathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level ... more

I.V. Román-Fernández; D.F. Ávila-Castillo; S. Cerpa-Cruz; S. Gutiérrez-Ureña; J. Hernández-Bello; J.R. Padilla-Gutiérrez; Y. Valle; M.G. Ramírez-Dueñas; A.L. Pereira-Suárez; J.F. Muñoz-Valle
10/24/2016
Bioantimutagenesis; Chemoprevention; Functional food; Macaúba; Nutraceutical

Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/ ... more

R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva; R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva; R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva
11/03/2016
Asthma; Environmental factors; IL-4; Pets; Smoking

Asthma is an allergic disease characterized by hyperresponsiveness and chronic inflammation of the airway. The interleukin-4 (IL-4) gene and its single nucleotide polymorphisms are associated with asthma susceptibility in children. A case-control study was performed to evaluate the relationship between asthma risk and the ... more

L. Li; Y. Li; X.C. Zeng; J. Li; X.Y. Du
11/03/2016
Berkshire pig; HSD17B4; Meat-quality trait; Single nucleotide polymorphisms

Single nucleotide polymorphisms (SNPs) are useful genetic markers that allow correlation of genetic sequences with phenotypic traits. It is shown here that HSD17B4, a bifunctional enzyme mediating dehydrogenation and anhydration during β-oxidation of long-chain fatty acids, contains a non-synonymous SNP (nsSNP) of chr2:128,825,976A>G, ... more

J.L. Jo; J.H. Hwang; S.G. Kwon; D.H. Park; T.W. Kim; D.G. Kang; G.E. Yu; I.S. Kim; J.G. Ha; C.W. Kim; J.L. Jo; J.H. Hwang; S.G. Kwon; D.H. Park; T.W. Kim; D.G. Kang; G.E. Yu; I.S. Kim; J. Ha; C.W. Kim
11/03/2016
High-resolution melting; Pinctada fucata; SNP; Transcriptome sequencing

The pearl oyster Pinctada fucata is an important commercial marine shellfish that is cultured for producing saltwater pearls. In this study, 468 single nucleotide polymorphisms (SNPs) were screened from P. fucata transcriptome data, and 119 polymorphic SNPs were successfully isolated by a two-step small-amplicon high-resolution melting assay. Of ... more

S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu; S.G. Fan; J.F. Wei; Y.H. Guo; G.J. Huang; D.H. Yu
11/21/2016
Loci transferability; Microsatellite loci; Next-generation sequencing; Sillago japonica; Sillago sihama

Sillago sihama (Forsskål, 1775), a commercially important marine fishery species in the Indo-West Pacific, is being developed as a target species for aquaculture and stock enhancement in China. However, due to the limitations of traditional isolation methods, the available microsatellite loci, or simple sequence repeats (SSRs), of S. sihama lack ... more

R.X. Wu; H.R. Zhang; S.F. Niu; Y. Zhai; X.F. Liu; R.X. Wu; H.R. Zhang; S.F. Niu; Y. Zhai; X.F. Liu
11/03/2016
Age distribution; Cervical cancer; Human papilloma virus; Multiple infection; Subtype distribution

The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection ... more

J. Li; Y.Y. Wang; X.F. Tian; X. Nan; T. Yan; P. Wang; Y.L. Fu; G.Q. Wang
11/03/2016
Deciduous teeth; Pathway analyses; Pathway-related modules; Permanent teeth; Reverse transcription-polymerase chain reaction

The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly different modules between permanent and deciduous teeth via network and pathway analyses. We ... more

J. Kang; R. Bai; K. Liu; X.P. Ji; Y. Li; J.Y. Han
11/03/2016
IL10 haplotypes; IL10 polymorphisms; Linkage disequilibrium; Mexican Mestizo population; Western Mexico

Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune ... more

M. Vázquez-Villamar; C.A. Palafox-Sánchez; J. Hernández-Bello; J.F. Muñoz-Valle; Y. Valle; A. Cruz; A.I. Alatorre-Meza; E. Oregon-Romero
11/03/2016
Classic Kaposi sarcoma; miR-146a; miR-149; Polymorphism

Classic Kaposi sarcoma is a type of vascular proliferative inflammatory disease. Previous studies have reported significant associations between microRNAs expression and the development of classic Kaposi sarcoma. Here, we conducted a case-control study to investigate the association between miR-146a and miR-149 genetic polymorphisms and ... more

H. Yang; Q.L. Lu; X.J. Wu; H.Y. Ma; Y.Y. Qu; D.Z. Zhang; X.M. Pu

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