Research Article

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11/03/2016
Diagnosis; Lung cancer; Lung cancer screen; Serum tumor markers

Early detection and treatment is critically important for lung cancer patients. Inflammatory mediators such as IL-6, IL-10, and MCP-1 participate in lung cancer regulation. CEA, CA125, and ProGRP are commonly used serum tumor markers for lung cancer. In this study, we assessed the sensitivity and specificity of CEA, CA125, and ProGRP when used in combination with ... more

Y.W. Pan; Z.G. Zhou; M. Wang; J.Q. Dong; K.P. Du; S. Li; Y.L. Liu; P.J. Lv; J.B. Gao; Y.W. Pan; Z.G. Zhou; M. Wang; J.Q. Dong; K.P. Du; S. Li; Y.L. Liu; P.J. Lv; J.B. Gao
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Cancer cell proliferation; Lung cancer; miR-129b; Non-small cell lung carcinoma

Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung cancer therapies, the mechanisms ... more

L. Zheng; Y.X. Qi; S. Liu; M.L. Shi; W.P. Yang
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Atrial fibrillation; Connexin 40; Gene polymorphism

We aimed to elucidate the association between connexin 40 (Cx40) genetic polymorphisms and atrial fibrillation (AF) in a Chinese population in Xinjiang comprising Uyghur and Han individuals. We enrolled 275 Uyghur and 305 age- and gender-matched Han subjects, and used polymerase chain reaction to detect single nucleotide polymorphisms (SNPs; -44G/A and +71A/G) in ... more

J. Hailati; Y.C. Yang; L. Zhang; P.Y. He; M. Baikeyi; W. Muhuyati; Z.Q. Liu
10/24/2016
Gene polymorphism; Osteoarticular tuberculosis; Prognosis; Tumor necrosis factor-α

This study investigated the association of tumor necrosis factor-α (TNF-α)-308, -238, and -863 polymorphisms with osteoarticular tuberculosis (OA-TB) prognosis in a Hebei population. Genomic DNA was extracted from venous blood samples of 120 OA-TB patients and 100 healthy volunteers. TNF-α-308, -238, and -863 were analyzed by PCR-restriction ... more

Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang; Y.J. Lv; S.J. Liu; W.N. Hu; G.P. Zhang; Q.Y. Ren; L.D. Zheng; Y.C. Zhang; R.Q. Li; Z.K. Zhang
11/03/2016
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo
11/03/2016
Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li; N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li
11/03/2016
COL9A1; Congenital talipes equinovarus; Polymorphism

Talipes equinovarus is a common congenital deformity. COL9A1 polymorphisms are associated with the development of articular cartilage-related diseases. In the current study, we evaluated the relationship between COL9A1 rs1135056, rs35470562, and rs592121 genetic polymorphisms and risk of congenital talipes equinovarus ... more

X.L. Zhao; Y.J. Wang; Y.L. Wu; W.H. Han
11/03/2016
Idiopathic infertility; p53 polymorphism; Spermatogenesis

Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it ... more

M.P. de Morais; R.F. Curado; K.S.Fe Silva; K.K.V.O. Moura; J.T. Arruda
11/03/2016
Alpha-actinin 3; Angiotensin-converting enzyme; Muscle fiber; Polymorphism; Scoliosis

The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and α-actinin-3. Ninety-seven females with scoliosis, ... more

R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa; R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa
11/21/2016
IL-8; Meta-analysis; Periodontitis; Polymorphism

The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies ... more

Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan; Z.J. Yang; X.P. Tang; Q.G. Lai; J.B. Ci; K.F. Yuan

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