Research Article

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07/28/2015
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Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In this study, we assessed the ... more

Y.P. Gu; Q.Y. Yuan; H. Zhang; C.J. Wang; F. Zhou
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The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs ... more

D.B. Tian; S.X. Cai; G.C. Pan; Y.F. Zhang; J.H. Xiao
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Cirrhosis; Meta-analysis; Proton pump inhibitor; Spontaneous bacterial peritonitis

We used a meta-analysis approach to investigate the association between proton pump inhibitor (PPI) use and risk of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. We searched Ovid Medline, Embase, and the Cochrane Library to identify eligible studies. We included studies that compared cirrhotic patients who did or did not use PPIs. The primary outcome was SBP, and the ... more

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HNF1B rs4430796 (A>G) polymorphism; Meta-analysis; Prostate cancer

Genome-wide studies have reported an association between the HNF1B rs4430796 (A>G) polymorphism and prostate cancer risk, but results have been inconsistent and recent meta-analyses have been inadequate. This study aimed to integrate previous results and explore the validity of this association. Electronic searches for all relevant publications through May 18, 2014, were ... more

Y. Zhao; J. Liang; J.G. Qi; N. Yang; G. Wu; Y.L. Lin; J.Y. Cao; Q. Wang; Q.C. Wang
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Diagnosis; Meta-analysis; MicroRNAs; Thyroid cancer

The aim of this meta-analysis was to systematically evaluate the diagnostic accuracy of microRNAs (miRNAs) in distinguishing malignant thyroid lesions from benign ones and to determine the potential of miRNAs as diagnostic biomarkers for thyroid cancer. The random-effect model was used to summarize the pooled estimates of diagnostic accuracy, including sensitivity, specificity, positive ... more

G.J. Zhou; M. Xiao; L.N. Zhao; J.G. Tang; L. Zhang
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Meta-analysis; Polymorphism; Prostate cancer

Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independently by two investigators. Pooled ... more

H.S. Zhu; J.F. Zhang; J.D. Zhou; M.J. Zhang; H.X. Hu
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Cardiopulmonary bypass; Interleukin-6; Interleukin-8; Meta-analysis; Sevoflurane

This study aimed to investigate the effect of sevoflurane on serum levels of interleukin (IL)-6 and IL-8 in patients who underwent cardiopulmonary bypass (CPB). The strength of the association between sevoflurane treatment and serum level of IL-6 and IL-8 was determined in patients who underwent CPB by summary standard mean differences (SMDs); 95% confidence interval (CI) was used. In ... more

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12/29/2015
Interleukin-10; Meta-analysis; Nasopharyngeal carcinoma; Polymorphism; Promoter genes

It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-control studies and two cohort ... more

Y.F. Yu; Z.G. Han; W.B. Guo; G.J. Zhang; J.K. Yang; F.L. Wu; Q.Y. Ou; Y.H. Li; X.Y. Cai; Z.N. Zhan; J.H. Chen; W.L. Xie; L. Tang; C.D. Liu
12/29/2015
GSTM1; GSTT1; Meta-analysis; Polymorphism; Varicocele

The glutathione S-transferase (GST) family represents a major group of detoxification and antioxidant enzymes. Studies have shown that high oxidative stress levels are associated with varicocele. The objective of this study was to assess the relationship between GSTM1 and GSTT1 null polymorphisms and varicocele using a study group of 497 varicocele patients and 476 ... more

B. Zhu; L. Yin; J.Y. Zhang
12/29/2015
Cancer; MALAT1; Meta-analysis; Pathological features; Prognosis; Protein expression

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been identified as a potential cancer biomarker, yet the mechanism by which it influences the development of cancer remains unknown. In this study, we aimed to correlate MALAT1 expression with pathological features and prognosis in cancer patients. Several databases were searched using combinations of ... more

X.S. Shi; J. Li; R.H. Yang; G.R. Zhao; H.P. Zhou; W.X. Zeng; M. Zhou

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