Research Article

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The -251A/T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene has been implicated in susceptibility to periodontitis; however, this correlation has not been elucidated. In this meta-analysis, we investigated the association between the IL-8 -251A/T polymorphism and the risk of periodontitis. All eligible case-control studies ... more

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Systemic lupus erythematosus (SLE) is a complex autoimmune disorder presenting heterogeneous clinical manifestations. A number of genes involved in SLE susceptibility are related to the type I interferon (IFN) pathway. IFN mediates innate immune responses and its increased levels contribute to the breakdown of peripheral tolerance. Interferon-induced helicase C ... more

deAzevêdo Silva; S.C. Lima; C. Addobbati; R. Moura; L.A.Cavalcanti Brandão; J.A.Trés Pancoto; E.A. Donadi; S. Crovella; P. Sandrin-Garcia
11/03/2016
Chinese Han population; Dopamine D2 receptor; Heroin dependence; Single nucleotide polymorphism

Heroin dependence is a chronic relapsing brain disease. Researchers have reported that the dopamine D2 receptor (DRD2) is involved in the development of opiate dependence. To identify markers that contribute to the genetic susceptibility to heroin addiction, we examined the potential association between heroin dependence and ... more

N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li; N. Wang; J.B. Zhang; J. Zhao; X.T. Cai; Y.S. Zhu; S.B. Li
11/03/2016
COL9A1; Congenital talipes equinovarus; Polymorphism

Talipes equinovarus is a common congenital deformity. COL9A1 polymorphisms are associated with the development of articular cartilage-related diseases. In the current study, we evaluated the relationship between COL9A1 rs1135056, rs35470562, and rs592121 genetic polymorphisms and risk of congenital talipes equinovarus ... more

X.L. Zhao; Y.J. Wang; Y.L. Wu; W.H. Han
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Correlation analysis; CYP1A1, GSTP1, ERCC2, XRCC1, XRCC3; Gene polymorphism; Lung cancer

Lung cancer is a common malignant tumor that is characterized by high morbidity and poor prognosis. Studies suggest that an individual’s genetic background affects the risk of developing lung cancer. Therefore, we investigated the relationship between gene polymorphisms and susceptibility to lung cancer. We recruited 308 primary lung ... more

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11/03/2016
Idiopathic infertility; p53 polymorphism; Spermatogenesis

Many environmental agents affect the development of male germ cells at different stages. Apoptosis is common during normal spermatogenesis; it plays an important role in controlling the number of germ cells and the disposal of defective stem cells to produce functional sperm. The presence of p53 in primary spermatocytes suggests that it ... more

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11/03/2016
Alpha-actinin 3; Angiotensin-converting enzyme; Muscle fiber; Polymorphism; Scoliosis

The etiology of adolescent idiopathic scoliosis remains unknown. Angiotensin-converting enzyme and α-actinin-3 polymorphisms influence the characteristics of muscle fibers. The aim of this study was to examine the association between idiopathic scoliosis and genetic polymorphism of angiotensin-converting enzyme and α-actinin-3. Ninety-seven females with scoliosis, ... more

R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa; R.P. Luciano; M. Wajchenberg; S.S. Almeida; C.E.N. Amorim; L.M.R. Rodrigues; R.C. Araujo; E.B. Puertas; F. Faloppa
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Gestational diabetes mellitus; Insulin resistance; Lipoprotein lipase gene polymorphism

The aim of this study was to investigate the relationship between a lipoprotein lipase (LPL) gene polymorphism in placental tissue and insulin resistance (IR) in patients with gestational diabetes mellitus. Using polymerase chain reaction-restriction enzyme fragment length polymorphism (PCR-RFLP) analysis, the LPL HindIII RFLP was examined in the placental tissue of 110 ... more

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Gestational diabetes mellitus; GSTM1; GSTP1 IIe105Val; GSTT1; Polymorphism

We investigate the role of the GSTM1, GSTT1, and GSTP1 IIe105Val genetic polymorphisms in the susceptibility to gestational diabetes mellitus. A total of 223 pregnant women with gestational diabetes mellitus and 265 healthy pregnant women were examined at The Second Affiliated Hospital of Shaanxi University of Chinese Medicine from May 2013 to November 2013. ... more

Y.H. Qiu; Y.L. Xu; W.H. Zhang; Y.H. Qiu; Y.L. Xu; W.H. Zhang
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Gestational diabetes mellitus; Polymorphism; Scientific production

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes ... more

J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues; J.S. Gomes; L.B. Minasi; A.D. da Cruz; F.M. Rodrigues

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