Research Article

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Admixed population; African ancestry; Amerindian ancestry; Ancestry informative markers; European ancestry; Single nucleotide polymorphism

Some studies of polymorphisms in prostate cancer (PCa) analyze individuals in a uniform manner, regardless of genetic ancestry. However, PCa aggressiveness differs between subjects of African descent and those of European extraction. Thus, genetic ancestry analysis may be used to detect population stratification in case-control association studies. We genotyped 11 ... more

J.S. Oliveira; R.S. Ferreira; L.M. Santos; L.J. Marin; R.X. Corrêa; M.R. Luizon; A.L. Simões; S.R. Gadelha; S.M.B. Sousa
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We aimed to measure the invasion ability of Hep-2 laryngeal cancer cells after treatment with C-erbB-2-small interfering RNA (siRNA)-chitosan nanoparticles, and assess the applied value of chitosan nanoparticle-mediated C-erbB-2 interference in inhibiting laryngeal cancer invasion and metastasis. Nanoparticles of approximately 100 nm, comprising ... more

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Bipolar disorder; Klinefelter syndrome; Sex chromosomal disorder

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Brazilian red pepper essential oil; Ex vivo; Intestinal alkaline phosphatase; Intestinal explants; Sodium butyrate; Swine

In this study, we evaluated the effect of intestinal alkaline phosphatase (IAP) and sodium butyrate (NaBu) on lipopolysaccharide (LPS)-induced intestinal inflammation. Intestinal alkaline phosphatase and RelA/p65 (NF-κB) gene expressions in porcine jejunum explants were evaluated following exposure to sodium butyrate (NaBu) and essential oil from Brazilian red ... more

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Ankylosing spondylitis; IL-4 rs2227282; IL-4 rs2243250; Interleukin-4; Serum levels; Single nucleotide polymorphism

We aimed to investigate the effect of two common polymorphisms in interleukin-4 (IL-4) on serum IL-4 levels and the development of ankylosing spondylitis (AS) in the Chinese population. A total of 420 inpatients and outpatients diagnosed with AS were enrolled as the case group, and 330 healthy volunteers were selected as the control group. IL-4 ... more

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Congenital heart disease; MicroRNA; miR-196a2; Single nucleotide polymorphisms

We hypothesized that single nucleotide polymorphisms (SNPs) in certain microRNAs contribute to congenital heart disease (CHD) phenotypes. Five hundred and seventy-three subjects were enrolled in this study. DNA extracted from peripheral blood cells was used for SNP genotyping of miR-196a2 (rs11614913), miR-27a (rs11671784, rs895819), and miR-499 (rs3746444). Allele ... more

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Endoplasmic reticulum stress; High glucose; Rosuvastatin

It is well established that endothelial injury plays an essential role in atherosclerotic plaque formation. Accumulating evidence has shown that high glucose levels may detrimentally affect cultured endothelial cells through endoplasmic reticulum (ER) stress. In this study, we investigated the effect of rosuvastatin on high glucose-induced ER stress in human ... more

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Balanced translocation; Breakpoint; Chromosome 7; Genetic counseling; Male infertility

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Gene polymorphism; Osteoarticular tuberculosis; Prognosis; Tumor necrosis factor-α

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