Research Article

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Ischemia/reperfusion (I/R) injury often triggers ventricular arrhythmia. Citrate binds calcium ions, forming a soluble calcium citrate complex that may reduce I/R injury by affecting calcium ion concentration. We tested the effects of citrate pretreatment on ventricular heart rate and related factors in a rat I/R model. Fifty male Sprague Dawley rats weighing 350- ... more

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To preliminarily clarify the mechanism of cardiac microvascular endothelial barrier function leading to heart failure, primary HMVEC-D cells were selected and cultured for amplification. The cells were infected with adenovirus vector containing the ADP-ribosylation factor 6 (Arf6) Q67L gene. Full-length and functional fragments of myeloid differentiation ... more

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Liguistium wallichii; NF-κB; Renal carcinoma; UBE3A

Renal carcinoma accounts for a fifth of the morbidity among malignant tumors in China. Ubiquitin-protein ligase E3A (UBE3A) plays an important role in the occurrence and development of gene mutation-induced diseases. This study was designed to investigate the mechanism of Liguistium wallichii in treating renal carcinoma. Hematoxylin and eosin staining was ... more

J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu; J.S. Wu; P.M. Zhang; L.J. Sun; X.Z. Liu
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Duodenal ulcer; Helicobacter pylori; Macrophage migration-inhibitory factor (MIF); MIF expression

The aim of this study was to examine the expression of macrophage migration-inhibitory factor (MIF) in duodenal ulcer epithelial cells and its relation to Helicobacter pylori (Hp) infection, and to discuss the pathogenic roles of MIF expression and Hp infection in duodenal ulcer. MIF protein and mRNA expression was examined in samples from patients with duodenal ulcer with and ... more

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frxA gene; Helicobacter pylori; MAS-PCR; Metronidazole; rdxA gene

Resistance to metronidazole (Mtz) in Helicobacter pylori is a major problem worldwide, especially in developing countries. Alterations in Mtz nitroreductase enzymes, such as oxygen-insensitive NADPH nitroreductase (RdxA) and NADPH flavin oxidoreductase (FrxA), are the major contributing factors for this resistance. In this study, rdxA and frxA were amplified, ... more

T.R.P. Butlop; N.T.N. Mungkote; N.T.R. Chaichanawongsaroj; T.R.P. Butlop; N.T.N. Mungkote; N.T.R. Chaichanawongsaroj
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Cardiomyocyte-like cells; Cell differentiation; Mesenchymal stem cells; Rehmannia glutinosa oligosaccharide

The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment group, and control group. ... more

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-1082A/G; -592A/C; CAD; IL-10; Polymorphism

Here, we conducted a case-control study to investigate the association between IL-10 gene polymorphisms and development of CAD in a Chinese population. A total of 220 patients with CAD and 236 control subjects who visited the Zhengzhou People’s Hospital between May 2012 and June 2014 were selected for this study. The IL-10-1082A/G and -592A/C ... more

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Clinically negative node; Meta-analysis; Radical neck dissection; Radiotherapy; Supraglottic carcinoma

The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were “supraglottic carcinoma”, “cervical lymph nodes negative/cN0”, “radical neck dissection”, and “radiotherapy”. The databases included the Chinese biomedical literature database, Medline, Cochrane ... more

Y.H. Liu; Z.W. Du
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Cancer cell proliferation; Lung cancer; miR-129b; Non-small cell lung carcinoma

Lung cancer is one of the most prevalent malignant tumors, and is one of the primary causes of cancer-associated deaths. In 2002, an estimated 1.18 million lung cancer-associated deaths were recorded, accounting for 18% of cancer-related deaths and 2% of total mortality. Despite the great progress that has been made in lung cancer therapies, the mechanisms ... more

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IL-8; Polymorphism; Primary gouty arthritis; rs2227306; rs4073

In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan’an ... more

Y.X. Cui; H. Zhao; H.Q. Guo

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