Research Article

Related GMR Articles

10/21/2015
Cyclooxygenase-2; Osteoarthritis; Rheumatoid arthritis; Synovial tissues

In this study, we investigated the differential expression profiles of cyclooxygenase-2 (COX-2) mRNA and proteins in osteoarthritis (OA) and rheumatoid arthritis (RA) patients to elucidate the role of COX-2 expression in the pathogenesis and development of these diseases and to provide novel drug targets for treating arthritis. A total of 60 patients who received arthroscopic surgeries ... more

H.W. Fan; G.Y. Liu; C.F. Zhao; X.F. Li; X.Y. Yang
01/22/2016
IL-18; Meta-analysis; Polymorphism; Rheumatoid arthritis

Interleukin-18 (IL-18), an important proinflammatory cytokine, has been reported to play a potential pathological role in rheumatoid arthritis (RA). Results from previous studies on the association between IL-18 polymorphisms and RA are conflicting. To clarify this, an updated meta-analysis of all available studies on IL-18 polymorphisms and RA was conducted. Eligible articles were ... more

L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen; L.L. Li; X.F. Deng; J.P. Li; N. Ning; X.L. Hou; J.L. Chen
05/05/2018
Gene polymorphism; IL-27; Rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease with increasing activity of T lymphocytes and abnormal production of inflammatory cytokines. Interleukin-27 (IL-27), a multifunction cytokine with contradictory inflammatory effect. Polymorphism of IL-27 was reported to be predisposed to many inflammatory diseases and autoimmune diseases. We aimed to assess the ... more

A. Badawy; A.H. Mohamed; A.A. Enein; R. Qasem; E. Rizk; E. El-Masry; S. Abdellatif; M. Balata
10/24/2016
Gynophore; MicroRNA sequencing; peanut

Peanut is one of the most important oilseed crops in the world that provides a significant amount of lipids and protein for many people. The gynophore plays an important role in gynophore development after fertilization of the peanut ovule. MicroRNAs (miRNAs) play an important role in numerous developmental and physiological plant ... more

Y. Shen; Y.H. Liu; X.J. Zhang; Q. Sha; Z.D. Chen; Y. Shen; Y.H. Liu; X.J. Zhang; Q. Sha; Z.D. Chen
11/03/2016
GHR; Growth curve; Sex-linked dwarf chickens

Sex-linked dwarf (SLD) chickens have been widely used in cross breeding of broilers and laying hens. To study the molecular mechanisms underlying growth hormone receptor (GHR) in SLD chickens, the expression profiles of GHR were measured in three growth related tissues (liver, breast, and thigh) in male and female S2 SLD chickens at ... more

H.Y. Huang; Z.H. Zhao; S.F. Li; Z. Liang; C.M. Li; Q.B. Wang
11/03/2016
Apoptosis; miR-1; Proliferation; Vestibular schwannoma

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover, miR-1 ... more

S.L. Li; X.H. Ma; J.F. Ji; H. Li; W. Liu; F.Z. Lu; S.T. Wu; Y. Zhang
11/21/2016
Apoptosis; Bcl-xL; Cervical cancer c-33a cells; miRNA 421

Cervical cancer is a life-threatening condition. MicroRNAs (miRNAs) can promote or inhibit cell death and proliferation. The present study investigated the effect of miRNA 421 on the growth and apoptosis of cervical cancer cells. miRNA 421 and control miRNA were synthesized and transfected into c-33a cervical cancer cells. A thiazolyl ... more

X.J. Lai; X.Y. Cheng; L.D. Hu
10/17/2016
Epinephelus coioides; IGF1Ra; IGF1Rb; Nucleotide diversity; Polymorphism

Orange-spotted grouper (Epinephelus coioides) is one of the most important marine fish and has a high market value. The insulin-like growth factor type 1 receptor (IGF1R) is a component of the insulin-like growth factor signaling system, and demonstrates important roles during growth. Based on information from livestock, we ... more

L. Guo; S. Yang; M.M. Li; Z.N. Meng; H.R. Lin; L. Guo; S. Yang; M.M. Li; Z.N. Meng; H.R. Lin
10/24/2016
Bioantimutagenesis; Chemoprevention; Functional food; Macaúba; Nutraceutical

Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/ ... more

R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva; R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva; R.J. Oliveira; N. de David; J.R. Pesarini; T.D. Nogueira; C.A.L. Kassuya; R.L.B. Strapasson; M.E.A. Stefanello; A.C.D. Monreal; R. Matuo; A.C.M.B. Antoniolli-Silva
11/03/2016
Gestational diabetes mellitus; Meta-analysis; PPARs; Pro12Ala polymorphism

The relationship between the Pro12Ala polymorphism of PPARγ and the risk of gestational diabetes mellitus remains unresolved. Here, we attempted to resolve this inconsistency. Case-control studies pertaining to the effect of the Pro12Ala polymorphism in the PPARγ protein and risk of gestational diabetes mellitus were extracted from the ... more

H.L. Shuai; X.Z. Lin; D.L. Chen; P. Li; X. Luo

Pages