Research Article

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12/21/2015
Hu sheep; Maternal behavior; PRLR gene; SNP

The prolactin receptor gene (PRLR) plays an essential role in maternal behavior. The aim of the study was to detect PRLR mutations in exon 10, using a polymerase chain reaction-single stranded conformation polymorphism method, and to determine the association between mutations in this region with maternal behavior traits in Chinese Hu sheep. Polymorphisms were detected ... more

L.P. Wang; R.Q. Geng; X.N. Zhang; W. Sun
12/22/2015
Expression profile; GAS6; Immunohistochemistry; Pig; SNP

The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. A recent report has demonstrated that the GAS6 gene can promote fat deposition and is associated with an increased number of fat cells in mice. In order to investigate ... more

D. Xu; J. Jiang; J. He; C.Q. He; H.M. Ma
12/21/2015
Age-related macular degeneration; Atrophic macular degeneration; Genome-wide association study; Oldest old; SNP

The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjects underwent a complete ophthalmic ... more

T.Q. Zhou; H.J. Guan; J.Y. Hu
12/17/2015
CYP1B1; Meta-analysis; Primary open-angle glaucoma; SNP

Mutations in the CYP1B1 gene were detected in primary open-angle glaucoma (POAG) patients. However, the association between these mutations and the incidence of POAG remains to be elucidated. Here, we have conducted a meta-analysis to analyze this correlation, using relevant studies obtained from an extensive search of various electronic databases, including EMBase, Web of ... more

Z. Wang; M. Li; L. Li; H. Sun; X.Y. Lin
12/02/2015
Genome-wide association study; Meat pH; SNP; Swine

Meat pH is an important factor influencing meat quality traits in swine. This study evaluated a large number of genetic variants that covered all of the swine chromosomal regions. Approximately 68,000 single nucleotide polymorphisms (SNPs), found on Illumina Porcine SNP chips, were tested for associations with meat pH values. A genome-wide association study (GWAS) found that 19 SNPs on ... more

H.Y. Chung; K.T. Lee; G.W. Jang; J.G. Choi; J.G. Hong; T.H. Kim
12/02/2015
Hepatocellular carcinoma; HLA-DP; Meta-analysis; SNP

The association between the HLA-DP single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 and hepatocellular carcinoma (HCC) has been reported, but results have been inconclusive and controversial. Therefore, to investigate the relationship between these HLA-DP SNPs and HCC susceptibility, a meta-analysis of studies published before January 2014 was carried out ... more

X. Zhang; C. Zheng; Z.H. Zhou; M. Li; Y.T. Gao; S.G. Jin; X.H. Sun; Y.Q. Gao
11/30/2015
Association analysis; Dilated cardiomyopathy; LMNA gene; SNP

Recently, studies on the pathogenesis of dilated cardiomyopathy (DCM) have focused on the underlying molecular biology and the association between single nucleotide polymorphisms (SNPs) and disease. This study was designed to explore the association between the rs4641 SNP of the LMNA gene and DCM in order to identify a new gene locus related to DCM. Polymerase chain reaction- ... more

J. Yin; J. Yang; F.X. Ren; C.M. Sun; L.D. Li; L.Y. Han; S.L. Cai; C.H. Zhang; Z.Q. Zhang; Z.T. Zhang; H. Wang
11/23/2015
Chicken; Piwi genes; SNP; Target-capture sequencing

The P-element-induced wimpy testis (Piwi) gene is involved in germline stem cell self-renewal, meiosis, RNA silencing, and transcriptional regulation. Piwi genes are relatively well conserved in many species, but their function in poultry species is unclear. In this study, Piwi genes were sequenced using a target-sequence capture assay in quail and 28 breeds of ... more

H.Z. Wang; T. Ma; G.B. Chang; F. Wan; X.P. Liu; L. Lu; L. Xu; J. Chen; G.H. Chen
11/13/2015
Cardiopathy; Post mortem analysis; SNaPshot; SNP; Sudden cardiac death

Sudden cardiac death (SCD) is a major public health concern worldwide, and genetic analysis may be useful in identifying the cause of death as well as in determining the possible genetic risk factors for SCD. This study analyzed eight SNPs (single nucleotide polymorphisms) highly correlated with cardiac sudden death in samples (blood and bone) from six Brazilian families with a history of ... more

D.F. Braganholi; R.M.B. Cicarelli
10/16/2015
ALOX5; Pharmacogenomics; PTGS2; SNP; VKORC1

Genetic polymorphisms of very important pharmacogenomic (VIP) variants are important for personalized medicine. However, these have not been extensively studied in the Tibetan population. In this study, 82 VIP variants were detected in the Tibetan and Han (HAN) populations from northwestern China. Subsequently, we compared the differences between the Tibetan population and ten populations ... more

T.B. Jin; X.J. Xun; X.G. Shi; D.Y. Yuan; T. Feng; T.T. Geng; L.L. Kang

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