Research Article

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Brazilian red pepper essential oil; Ex vivo; Intestinal alkaline phosphatase; Intestinal explants; Sodium butyrate; Swine

In this study, we evaluated the effect of intestinal alkaline phosphatase (IAP) and sodium butyrate (NaBu) on lipopolysaccharide (LPS)-induced intestinal inflammation. Intestinal alkaline phosphatase and RelA/p65 (NF-κB) gene expressions in porcine jejunum explants were evaluated following exposure to sodium butyrate (NaBu) and essential oil from Brazilian red ... more

A.D.B. Melo; H. Silveira; C. Bortoluzzi; L.J. Lara; C.A.P. Garbossa; G. Preis; L.B. Costa; M.H. Rostagno
Endoplasmic reticulum stress; High glucose; Rosuvastatin

It is well established that endothelial injury plays an essential role in atherosclerotic plaque formation. Accumulating evidence has shown that high glucose levels may detrimentally affect cultured endothelial cells through endoplasmic reticulum (ER) stress. In this study, we investigated the effect of rosuvastatin on high glucose-induced ER stress in human ... more

J.Z. Xu; Y.L. Chai; Y.L. Zhang
Balanced translocation; Breakpoint; Chromosome 7; Genetic counseling; Male infertility

Balanced reciprocal translocations are associated with reproductive failure. Some reciprocal translocation carriers exhibit azoospermia or oligozoospermia, and an association exists between these chromosomal abnormalities and recurrent abortion. Previous reports have indicated the involvement of chromosome 7 translocations in male infertility and recurrent ... more

R.X. Wang; H.G. Zhang; Y. Pan; J.H. Zhu; F.G. Yue; L.T. Xue; R.Z. Liu; R.X. Wang; H.G. Zhang; Y. Pan; J.H. Zhu; F.G. Yue; L.T. Xue; R.Z. Liu
Biomarker; Env; Gag; HIV; Molecular epidemiology; Pol

HIV genotyping has led to conflicting results between laboratories. Therefore, identifying the most accurate gene combinations to sequence remains a priority. Datasets of Chinese HIV subtypes based on several markers and deposited in PubMed, Metstr, CNKI, and VIP databases between 2000 and 2015 were studied. In total, 9177 cases of amplification-positive samples ... more

L. Ren; H.W. Wang; Y. Xu; Y. Feng; H.F. Zhang; K.H. Wang
Bacterial killing; CD209a; Helicobacter pylori; LECT2; Macrophages; NF-κB

Helicobacter pylori employs unique methods to colonize the stomach, which induces chronic inflammation. It is also able to avoid eradication by macrophages and other immune cells. Leukocyte cell-derived chemotaxin 2 (LECT2), a multi-functional cytokine involved in many pathological conditions, has recently been shown to activate macrophages via the CD209a ... more

H.X. Shen; L. Li; Q. Chen; Y.Q. He; C.H. Yu; C.Q. Chu; X.J. Lu; J. Chen
Gene expression; Housekeeping genes; Laminin; Macrophage; qPCR

Macrophages are essential components of the innate and adaptive immune responses, playing a decisive role in atherosclerosis, asthma, obesity, and cancer. The differential gene expression resulting from adhesion of macrophages to the extra-cellular matrix (ECM) has been studied in the J774A1 murine macrophage cell line using quantitative polymerase chain reaction (qPCR). The goal of this ... more

F.B. Ferraz; J.H. Fernandez; F.B. Ferraz; J.H. Fernandez
Body measurement traits; Carcass quality traits; SNP; STAT3

Previous studies have shown that the signal transducer and activator of transcription 3 gene (STAT3) is involved in lipid storage and energy metabolism, suggesting that STAT3 is a potential candidate gene that affects body measurement and carcass quality traits in animals. Therefore, the aim of this study was to identify polymorphisms in bovine STAT3 and to ... more

N. Song; L.S. Gui; H.C. Xu; S. Wu; L.S. Zan
CRH; Economic traits; Hanwoo; Korean cattle; POMC; SNP

The corticotrophin-releasing hormone (CRH) and proo­piomelanocortin (POMC) genes are considered to play an important role in the growth and development of mammals. In this study, the bovine CRH and POMC genes were characterized to detect genetic variation at these loci in relation to economic traits in Korean cattle (Hanwoo). Nine single ... more

J. Seong; H.S. Kong
Association study; Schizophrenia; SNP; VRK2 gene

Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total population of 893 ... more

B. Zhang; C.Y. Gao; H.B. Zhang; B. Yang; J.F. Yin; S.G. Wei; Y.S. Zhu; X.N. Jia; S.B. Li
COPD; Meta-analysis; rs3795879; SERPINE2; SNP

The present study aimed to investigate the effects of the rs3795879 polymorphism of the SERPINE2 gene on the development of chronic obstructive pulmonary disease (COPD) based on a systematic meta-analysis. An extensive literature search was performed to retrieve previously published case-control studies on the polymorphisms of SERPINE2 in COPD patients. Odds ratios (ORs ... more

D.B. Tian; S.X. Cai; G.C. Pan; Y.F. Zhang; J.H. Xiao